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Tag: "repair" at biology news

Advance helps explain stem cell behavior

...f you have an electrical problem in a car, you can repair it a lot easier if you have a wiring diagram," sai...at we're trying to do here, except we're trying to repair or create a certain kind of cell. To do that you need a blueprint of how these processes work, and t...

Neural stem cells lend the brain a surprising capacity for self-repair

...tantial mending within weeks. They attributed that repair to neural stem cell "escapees" that had somehow re...t known that the brain has this kind of ability to repair itself." Jan and his colleagues first discovered Numb in the fruit fly Drosophila more than 10 yea...

Experimental cancer drugs counter muscle deterioration seen in muscular dystrophy

...cetylase inhibitors, in promoting regeneration and repair of dystrophic muscles, thereby countering the progression of the disease, in two different mouse models of muscular dystrophy. Led by Burnham Institute assistant professor Lorenzo Puri, M.D., Ph.D., in collaboration with the Dulbecco Telethon Institu...

Researchers create genetically matched embryonic stem cells for transplantation

...sfer, to create customized embryonic stem cells to repair genetic defects in mice. But somatic cell nuclear transfer (sometimes called therapeutic cloning) is a technically demanding and inefficient process that involves transferring the nucleus of a donor cell into an egg from which the nucleus has been re...

Single molecular 'mark' seen as pivotal for genome compaction in spores and sperm

...tranded DNA, on the other hand, has the ability to repair breaks in one of its single strands by using the chemical bases in the companion strand as a reference. Bases in DNA pair only in predetermined combinations, so that one strand can serve as a template for the other. "Compaction might also affect sp...

Poor athletic performance linked to vitamin deficiency

...intensity exercise and have a decreased ability to repair and build muscle than counterparts with nutrient-r...nto energy, and are used during the production and repair of cells, including red blood cells. For active individuals a marginal deficiency in the nutrients...

Mayo discovers protein as potential tactic to prevent tumors

... component in the cellular mechanism that leads to repair of damaged DNA." If cells pass this quality control checkpoint, they can resume the process of dividing into two daughter cells. If, however, major irreparable discrepancies occur in the genetic code, cells are shunted toward a molecular sequence ...

Replacing insulin is top-ranked breakthrough foreseen for health in developing world

... (L.V. Prasad) has used adult stem cell therapy to repair the corneas of over 125 blind patients; an estimated 60% of blindness in poor communities is treatable. Regenerative medicine holds the promise of more affordable treatments than corneal grafts and of offsetting shortages of donor material. The stu...

Muscle and bone from an ink-jet printer

...searchers has demonstrated the ability of MDSCs to repair muscle in a model for Duchenne Muscular Dystrophy, improve cardiac function following heart failure, and heal large bone defects in the skull. Controlling not only what types of cells differentiate from stem cells, but also gaining spatial control of...

Regulating the nuclear architecture of the cell

...s are then free to interact; DNA recombination and repair processes excise the DNA from the chromosome to fo...e cell cycle when damaged DNA is detected, and DNA repair mechanisms move in to fix the damage." However, if these replication checkpoints are crippled in fli...

Drug can quickly mobilize an army of cells to repair injury

...bloodstream, homing to sites of injury and helping repair and regrow blood vessels that bring oxygen and nut...w oxygen," he says. "That way you enhance a normal repair mechanism instead of using the brute force of injecting a mixture of many cell types from bone marro...

Scientists explore how complex organs develop from a simple bud

...in the reviews --pertaining to the maintenance and repair of cells within adult branched organs, the role of cells only transiently associated with adult organs, and the extent to which defects in the growth and development of fetal stage organs can affect organ function after birth -- have important implic...

Nanoscale microscope sheds first light on gene repair

...ighly coordinated series of events to identify and repair the damage. The response is critical, and there i... and immunological problems when components of the repair processes are defective. Traditional microbiological and genetics techniques can shed light on t...

Sea urchin genome suprisingly similar to man and may hold key to cures

...hen we can begin to figure out how to intercede to repair and to heal," Calestani said. "It holds a lot of promise." Calestani is continuing her work with sea urchins at UCF in Orlando by examining the development of pigment cells found in the marine creatures. Those cells also might provide some insight...

Environmental toxins may cause body's defenses to worsen lung disease

... that damage exceeds the body's natural ability to repair tissue," he adds. "And through the destruction of lung tissue, it may actually start contributing to chronic lung disease instead of protecting against it." UC scientists say when this happens repeatedly--such as through environmental tobacco or wo...

Newts which regrow their hearts

... regrows. What is more, a newt can also completely repair damage to its heart. Scientists at the Max Planck Institute for Heart and Lung Research in Bad Nauheim have now started to decode the cellular mechanisms in this impressive ability to regenerate and have discovered the remarkable plasticity of newt h...

Smashing the time it takes to repair our bones

...stimulants which occurred naturally in the body to repair fractured and broken bones. "This device is about trying to grow bone tissue in the same environment our body grows bones. I have taken bone cells and put them in the physical environment they would experience in the body, and then varied the stim...

Molecular 'marker' on stem cells aids research, perhaps therapies

...for use in therapies aimed at bone healing, tendon repair and cartilage regeneration, researchers at UT Sout...es elsewhere, where scientists tested their use to repair bone defects and to attenuate the effects of bone loss in diseases such as osteoporosis. The study...

The effects of smoking on fractures and ligament injuries

...igarette smoke can undermine fracture and ligament repair following injury. In addition, smokers have higher rates of hip fracture, fracture healing problems and bone infections and smoking has been shown to impair soft tissue wound healing. Two new studies, funded by the National Institutes of Health and t...

Stem cells engage in dialogue with the cells that regulate their futures

...regenerative medicine: tapping into the ways cells repair the body to create therapies to fix or replace injured tissues. She mentioned that it is thought that most, if not all, adult tissues contain stem cells. Through self-renewing division," she explained, "stem cells replenish the stem cell pool. The...

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