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Tag: "repair" at biology news

Mutant gene causes severe kidney disease in infants

... birth. A milder mutation seemed to interfere with repair mechanisms in the glomerulus, so defects didn't show up until later in life." U-M scientists used DNA microarrays to analyze blood samples from 26 families around the world who had children diagnosed with steroid-resistant nephrotic syndrome. Afte...

Lungs try to repair damaged elastic fibers

...ic obstructive pulmonary disease (COPD) attempt to repair damaged elastic fibers, a new finding that contrad...udy "Evidence for attempted regional elastic fiber repair in severe emphysema," was done by Jason Woods, Kristin Castillo, Alexander Patterson and Richard Pie...

Dopamine used to prompt nerve tissue to regrow

... build neurotransmitters into the material used to repair a broken circuit. The neurotransmitters could coax...ents suffering from neurological disorders to help repair damaged nerves. The findings were published online the week of Oct. 30 in the Proceedings of the Nat...

Key to zebrafish heart regeneration uncovered

... of the zebrafish heart could lead to therapies to repair human heart muscle damaged by disease or heart attack. "Multiple types of progenitor cells have been identified within the mammalian heart, yet it displays little or no regeneration when damaged," Poss said. "By contrast, zebrafish mount a vigorou...

Osteoarthritis may be sign of faster 'biological ageing'

...ake them shorten over time, including insufficient repair of the damage caused by oxygen free radicals (oxidative stress). Oxygen free radicals are the unstable molecules produced as a by-product of normal bodily processes, as well as external factors, such as tobacco, alcohol, and sunlight. Osteoarthri...

U of MN researchers turn cord blood into lung cells

...acs. The cells are also responsible for helping to repair the airway after injury. "In the future, we may be able to examine cord blood from babies who have lung diseases, such as cystic fibrosis, to do more research to understand how these diseases evolve as well as to develop better medical treatments,...

Dig deeper to find Martian life

...he effects because, when active, they successfully repair the DNA breaks caused by ionising radiation. Howev...bsurface of Mars, they are preserved but unable to repair the damage, which accumulates to the point where the cell becomes permanently inactivated. Mr Dar...

Research project tackles 'regeneration' gap

...nd then applying this knowledge toward encouraging repair in the more complex human, where regeneration is n...uries. Similarly, the body has limited capacity to repair injured limbs or spinal cords. Regeneration researchers seek to strengthen the body’s inherent heali...

Protein averts cell suicide but might contribute to cancer

... continue, so the cell doesn't die. But they don't repair the DNA damage that exists." DNA damage is a r... loses more than 10,000 DNA bases daily. Dedicated repair enzymes fix 80 percent or more of this damage, but the rest remains. Cells use Y-family enzymes ...

When smell cells fail they call in stem cell reserves

... identified a backup supply of stem cells that can repair the most severe damage to the nerves responsible f...orting a class of active-duty stem cells that help repair normal wear and tear. They don’t come in until things are really bad.? The only nerve cells in th...

Stem cell therapy shows promise in regenerating damaged muscle in heart attack patients

...tem cells are designed by nature to perform tissue repair in a mature adult. It is believed that these cells can be used in patients unrelated to the donor, without rejection, eliminating the need for donor matching and recipient immune suppression. Once transplanted, the cells promote healing of damaged or...

Nanoparticles can track cells deep within living organisms

...the blood supply to diabetic patients' limbs or to repair blood vessels after a heart attack or bypass surgery. Tracking nanoparticle-labeled cells used in such treatments by MRI imaging would allow physicians to monitor the treatment's success or failure. The nanoparticles ?called "nano" because they m...

Reactivated gene shrinks tumors

...words, when functioning properly, it activates DNA repair mechanisms and prevents cells with damaged DNA from dividing. If DNA damage is irreparable, p53 induces the cell to destroy itself by undergoing apoptosis, or programmed cell death. When p53 is turned off by mutation or deletion, cells are much mo...

Scientists identify specific enzymes that make meningitis hard to fight

...'s efforts to fight off the disease. Together they repair damage done to the meningitis bacteria's DNA by th...ever, the virulent meningitis bacteria are able to repair this harmful damage and are therefore unaffected by the body's defences. The research team found ...

Liposuctioned fat stem cells to repair bodies

...fat also contains stem cells with the potential to repair defects and heal injuries in the body. A team led ...s to regenerate the tendon structure that does not repair spontaneously," says Galli. Once scar tissue is formed, it hinders the animal’s recovery. "If you i...

Tissue engineering for craniofacial reconstruction

...aditional transplants. Tissue engineers attempt to repair or regenerate damaged tissue by using engineered tissue substitutes that can sustain functionality during regeneration and eventually integrate into the host tissue. The traditional tissue-engineering paradigm combines isolated cells with appropriate...

Bacteria could steady buildings against earthquakes

...have been used on a smaller scale, for example, to repair cracks in statues, but not to reinforce soil. The new method has several advantages, DeJong said. There are no toxicity problems, compared with chemical methods. The treatment could be done after construction or on an existing building, and the st...

Pregnancy hormone key to repairing nerve cell damage

... the effects of pregnancy on myelin production and repair in mice that weren't pregnant. "The results of this study should be well received by people living with MS today," said Dr. William McIlroy, national medical advisor for the Multiple Sclerosis Society of Canada. "It represents a new insight of ...

Stanford scientists make major breakthrough in regenerative medicine

..., broken spines, and wounded muscles always try to repair themselves, but often the result is invalidism or disease. Even some tumors try to revert to normal, but are unsuccessful. If the genetic sequence described in the sea squirt applies to humans, this study represents a major step for regenerative med...

Scientists uncover new target in cancer mutation puzzle

...ke advantage of the mutations instead of trying to repair them. The research is reported online this week in the journal Nature Structural & Molecular Biology. In experiments with rodent and human cells, co-authors Mingxuan Xia, Ph.D., and Hartmut Land, Ph.D., explored how the Rho family of proteins, w...

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