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Tag: "repair" at biology news

Wisconsin scientists grow critical nerve cells

...ovide critical guideposts for scientists trying to repair damaged or diseased nervous systems. Motor neurons transmit messages from the brain and spinal cord, dictating almost every movement in the body from the wiggling of a toe to the rolling of an eyeball. The new development could one day help victims...

Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer

Deficiencies in the ability of cells to repair damaged DNA are associated with an increased risk ...he Journal of the National Cancer Institute. DNA repair is the system of defenses designed to protect the integrity of the genome. Studies have suggested t...

Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer

...ion.Thus, most mammals, including humans, can only repair these lesionsthrough a much less direct and elaborate process called nucleotideexcision repair.In the new work, Dr. Bert van der Horst and colleagues studied theeffects of CPD and 6-4PP lesions by providing mice with transgenesencoding CPD and 6-4PP ...

New binding target for oncogenic viral protein

...ll division and the transcription, replication and repair of DNA. T antigen also inactivates some of the most important proteins that protect cells against malignant transformation, including tumor suppressor proteins p53 and pRb. In the Journal of Biological Chemistry paper, Dr. Welcker and Dr. Bruce Clur...

Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs

...e used by the body to form new blood vessels or to repair damagedones. Decreasedblood flow in the legs is c...s, or by repairing the diseasedblood vessels. This repair process results in improved circulation evenduring exercise. Some people are not able to repair thei...

Gene therapy converts dead bone graft to new, living tissue

...tilage, even in a healthy person, can't re-grow or repair itself. "It's a steeper challenge that would require additional technology such as light-activated gene therapy (LAGT) to site-specifically target the genes to the edge of the damaged cartilage during arthroscopic surgery, but we're looking to use t...

Molecular machine may lead to new drugs to combat human diseases

...targeted trans-splicing technique has been used to repair hemoglobin infected with sickle cell anemia. The new structure provides scientists with tools to expand on ways to harness this molecular machine, Golden said. The other researchers on this study were Hajeong Kim, graduate student, and Elaine Chase,...

Vital step in cellular migration described by UCSD medical researchers

...ent of cells within the body during growth, tissue repair and the body's immune response to invading pathogens, has been demonstrated by researchers in the University of California, San Diego (UCSD) School of Medicine. Published in the March 27 online edition of Nature Cell Biology and the journal's upcomin...

Scientists identify genetic pathways essential to RNA interference

...d with the regulation of DNA itself, including the repair of DNA damage. "These new steps indicate there is more to RNAi than RNA destruction," says Kim. "And the connection to DNA damage pathways, which was totally unexpected, suggests a potential connection between RNAi and the control of cell division in...

Gene Therapy For Parkinson's Disease Moves Forward In Animals

..., promises to have a place for both protection and repair in Parkinson's disease,?said Dennis Steindler, Ph.D., director of the McKnight Brain Institute and a professor of neuroscience. “It is important to appropriately introduce the GDNF into the Parkinson's disease setting, where that introduction can pro...

Researchers add new tool to tumor-treatment arsenal

...mage is too severe, or allowing the cancer cell to repair the damaged DNA. If the DNA is repaired, cells can...be toxic, and doses that are too low allow for DNA repair and further cell growth. Thus, says Dr. Thomas, there is need for drugs that can sensitize cells to ...

Research Gives Hope For Liver Damage

...as hindered progress in finding ways to preventand repair liver damage. Now that we have shown how the macro...he role of these immune-system cells in damage and repair toother organs, including the kidney....

Nano-Probes Allow an Inside Look at Cell Nuclei

...reactions inside nuclei, such as how proteins help repair DNA after irradiation. They have already visualized the dots' journey from the area surrounding the nucleus to inside the nucleus, a feat that opens the door for real-time observations of nuclear trafficking mechanisms. They also hope to target other...

DNA Recombination and Repair—A New Twist to RecA Function

...e of the shared sequence. It can also initiate the repair of DNA lesions during replication—the process by which a DNA molecule is copied to make two. RecA is also an ATPase, an enzyme capable of hydrolyzing (breaking down) ATP, when bound to DNA. RecA uses ATP to carry out strand exchange over long sequen...

NJIT Presidential Award winner takes stem cell research another step

...llografts ?donated bone tissue - to regenerate and repair the patients' damaged bones. She is performing tes...s that, in combination with stem cells, might also repair cartilage, tendon and neuronal tissues. Her studies could lead to medical breakthroughs that would ...

UCSD team discovers specialized, rare heart stem cells in newborns

...artificial and animal derived valves to surgically repair heart defects. While progenitor cells won't grow a...n living animals to study their role in endogenous repair after cardiac injury. ...

Gene therapy for Parkinson's disease moves forward in animals

..., promises to have a place for both protection and repair in Parkinson's disease," said Dennis Steindler, Ph.D., director of the McKnight Brain Institute and a professor of neuroscience. "It is important to appropriately introduce the GDNF into the Parkinson's disease setting, where that introduction can pr...

Programmable cells: Engineer turns bacteria into living computers

...orkhorses that detect hazards, build structures or repair tissues and organs within the body. "We are reall...Programmed cells also could be used to control the repair or construction of tissues within the body, possibly guiding stem cells to the locations where they ...

Stem Cell Research Shows Potential for Replacing Tissue Damaged in Heart Attacks

...ind out whether cardiac myocytes from ES cells can repair diseased or damaged adult myocardium in non-human models. This last question is being answered in collaboration with John Auchampach, Ph.D., associate professor of pharmacology & toxicology, and Tim Nelson, Ph.D., a senior medical student. Their...

Single stem cells from bone heal a broken heart

...ts provide a foundation on which new approaches to repair the damaged heart can be based. Related : Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction, JCI ...

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