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Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats

... The healthier polyunsaturated fats are those that remain liquid at room temperature, such as various types of vegetable oils. Trans-unsaturated fatty acids, or trans fats, are artificially produced solid fats used in shortening and margarine, baked goods, and the oils used to cook french fries and other f...

Spleen may be source of versatile stem cells

...rize that a pocket of these uncommitted cellsmight remain in the spleen though adulthood. In addition toregeneration of islets, these cells might also produce bone cells -suggested by findings from other researchers - or potentially evencells of the nervous system, development of which depends on thecorrect...

Researchers discover way to make cells in the eye sensitive to light

...anglion cells, thecells which signal to the brain, remain intact. The researchers believethat by activating the melanopsin, these cells may gain the ability tosense and respond to light.Professor Mark Hankins, from Imperial College London and Charing CrossHospital, and one of the papers authors, comments: "...

It's not all genetic: Common epigenetic problem doubles cancer risk in mice

...rly turns on the copy of the IGF2 gene that should remain off. Unlike most genes, the copy of IGF2 that should be silent depends only on which parent it came from, a situation called genomic imprinting. For IGF2, the copy inherited from the mother is always supposed to be turned off. In the mice and in so...

Researchers Uncover Key Step In Manufacture of Memory Protein

...ansported to the cell’s outer membrane, where they remain until they are ready to be secreted. Once the cell receives an electrical signal from another neuron, these vesicles fuse with the cell’s outer membrane, open up, and release mBDNF. During their research, Dr. Loh and her colleagues observed mice gen...

Learning to fight an adversary that won't stay down

...who deal with microbial diseases in hospitals must remain cautious about exposing the bacterial pathogens to the newest and most effective drugs so as to avoid overuse and the accompanying onset of resistance. "There are a relatively small number of antibiotics that have come out that are new, and some of ...

Scientists rid stem cell culture of key animal cells

... are thought to play: ensuring that the stem cells remain in their undifferentiated state and capable of pro...feeder cells, two other sources of animal material remain in stem cell culture materials. One, Matrigel, is a product that is essentially a plate-coating matr...

Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease

...lthough the exact ways genes are turned on and off remain unknown, the tags in chromatin are believed to play a major role. Until now, however, it had not even been known which regions of the genome carry such tags. A complete surprise Most regions of the chromatin have only a few "on" tags, but in region...

U-M scientists find genes that control growth of common skin cancer

...y residual human BCCcells, if present, should also remain in check as long as the Hhpathway is effectively inhibited.Funding for this research was provided by grants from the NationalCancer Institute and the National Institute of Arthritis andMusculoskeletal and Skin Diseases....

First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers

...knowledge, that's a real first." Exact mechanisms remain unclear. "Obviously, these compounds are targeting some step in the cell-migration process," Dr. Huang said. The activity of a migration-linked protein called Rac appears to be much reduced in cancer cells affected by the analogues, and the research...

Open microfluidic and nanofluidic systems

...uids and other substrate materials. It should also remain valid if one further shrinks the surface channels and, in this way, moves deeper into the nanoregime. As one reaches a channel width of about 30 nanometer, one theoretically expects new effects arising from the line tension of the contact line, but s...

Gene Therapy For Parkinson's Disease Moves Forward In Animals

... that have been raised about GDNF. But many things remain that we still don't understand.?/p> The recent findings in laboratory animals were a joint effort of Lund University in Lund, Sweden, the University of Cambridge in the United Kingdom, and the McKnight Brain Institute and the Genetics Institute o...

Researchers trace evolution to relatively simple genetic changes

... a low level it is never seen;" all the ocean fish remain well-armored. "But they do have this silent gene that allows this alternative form to emerge if the fish colonize a new freshwater location." Also, comparing what happens to the ectodysplasin signaling molecule when its gene is mutated in humans, an...

Octopuses occasionally stroll around on two arms, UC Berkeley biologists report

... a low level it is never seen;" all the ocean fish remain well-armored. "But they do have this silent gene that allows this alternative form to emerge if the fish colonize a new freshwater location." Also, comparing what happens to the ectodysplasin signaling molecule when its gene is mutated in humans, an...

Nano-Probes Allow an Inside Look at Cell Nuclei

... are stable and nontoxic, they have the ability to remain in a cell's nucleus -- without harming the cell or fading out -- much longer than conventional fluorescent labels. This could give biologists a ringside seat to nuclear processes that span several hours or days, such as DNA replication, genomic alter...

Scientists identify new model Of NK cell development

...role. In contrast, B cells, which make antibodies, remain and mature in the bone marrow. Until now, scientists thought NK cells did the same. But Caligiuri, working with Aharon Freud, the lead author of the study and a doctoral candidate in Caligiuri's laboratory, had noted other work showing that mice lac...

New methods of gene delivery using lasers

... genes, the team grew the cells, which appeared to remain healthy and multiplied normally. The presence of the inserted gene in the multiplied cells was then confirmed by observing the red/green fluorescent proteins produced by the ‘new?gene. The study is published today by Optics Express: http://www.optic...

Boosting HIV screening can increase survival and is cost effective

...ons. The result is that 280,000 Americans with HIV remain unaware of their infection. Efforts to promote and finance routine, population-based HIV screening should be pursued aggressively." Douglas K. Owens, M.D., of the VA Palo Alto Health Care System, and his team at the VA, Stanford and St. Michael's Ho...

Unexpressed But Indispensable -- The DNA Sequences That Control Development

...lp point the way to other non-coding elements that remain undiscovered. It is also likely that mutations in these critical sequences cause human diseases. Studying how such mutations drive development astray may lead to better understanding not only of these diseases, which are likely to be rare, but also o...

Gene therapy for Parkinson's disease moves forward in animals

... that have been raised about GDNF. But many things remain that we still don't understand." The recent findings in laboratory animals were a joint effort of Lund University in Lund, Sweden, the University of Cambridge in the United Kingdom, and the McKnight Brain Institute and the Genetics Institute of the ...

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