Secret of smallpox's success may lead to bioterror cure
...ice and other animal models, using viruses closely related to smallpox that are lethal to those animals. "We're testing with vaccinia and mousepox in lab mice, and in dormice with monkeypox. These are good model systems ?if we can protect against mousepox in mice, then we have a high level of certainty that...Supercomputers to focus brains on AIDS dilemma
...ercomputer Center (SDSC) at UC San Diego. In 1999, related results from traditional x-ray crystallography studies of the structure of a complex between the HIV-1 integrase catalytic domain and an inhibitor pointed to the existence of only one site where inhibitors could bind. These studies indicated a single...Conserved amino acids play both structural and mechanistic roles in sandwich-like protein
...benefit future research on treatments for diseases related to misfolded proteins, such as Alzheimer's and Hun...ding is crucial for curing human diseases directly related to misfolding of proteins, and it is also important for the design and improvement of therapeutic en...Changing ecosystems throw scientists mega-challenges
...mplexity in the Environment program, and discusses related goals. "Environmental research and education should remain on the forefront of science funding" said David Skole, a geographer at Michigan State University and ACRE chair. " This document is an attempt to put forth for the ERE portfolio at NSF in th...wFleaBase: the Daphnia genome database
...f the Generic Model Organism Database project, and related bioinformatics tools. Over the coming year, preliminary genetic maps and the nearly complete genomic sequence of Daphnia pulex will be integrated into wFleaBase, including gene predictions and ortholog assignments based on sequence similarities with...Science study holds implications for gene therapy and stem cell biology
...aum said. Scientists, in general, experiment with related gene vectors to treat severe inborn disorders or cancer. There continues to be an increasing interest in gene therapy research with blood stem cells because these cells can be extracted and manipulated and then reinserted to repopulate the entire blo...Stealth Worms May Improve Insect Pest Control
...evolved in relation to each other and how they are related in a geographic region to affect similar hosts. "We always look at the insect and nematode interactions in the laboratory first, then go out and look at the crops and environment," Stock says. Some of her work involves comparing commercially availab...Scientists generate patient-specific stem cells, Science study says
...al enzymes and serum. In a Science "Policy Forum" related to the team's latest findings, David Magnus and Mildred Cho from Stanford University in Palo Alto, CA discuss international oversight and ethical issues in oocyte donation, including the need to promote realistic expectations of the outcomes of stem ...SuperLigands - a database of ligand structures derived from the Protein Data Bank
...al enzymes and serum. In a Science "Policy Forum" related to the team's latest findings, David Magnus and Mildred Cho from Stanford University in Palo Alto, CA discuss international oversight and ethical issues in oocyte donation, including the need to promote realistic expectations of the outcomes of stem ...15-year hunt finds cause of pseudothalidomide syndrome
..., it's not clear why. If the underlying biology is related somehow, then thalidomide might affect chromosomes and cell division like ESCO2 in Roberts syndrome, Jabs speculates. During normal cell division, every chromosome is copied, and each of the "original" chromosomes is attached to its "new" copy. Whil...WHO suspends Marburg work, appeals for new funds
...been seen during previous outbreaks of the closely related Ebola haemorrhagic fever. Two medical anthropologists are already in Uige and will be joined shortly by experts in social mobilization from Angola, the Democratic Republic of Congo, and Mozambique. Public compliance with control measures is not expec...Research into how prions act in the brain could hold the key to defeating diseases
...iseases such as Creutzfeld-Jakob Disease (CJD) and related conditions caused by tiny particles known as prions, thanks to a £300,000 grant from the Medical Research Council. So far, there have been 148 deaths from confirmed or probable variant CJD (vCJD) in the UK. This is the human disease thought to be ca...Where bacteria get their genes
...0 percent of their genetic material from distantly related bacteria species, according to new research from The University of Arizona in Tucson. The finding has important biomedical implications because such gene-swapping, or lateral gene transfer, is the way many pathogenic bacteria pick up antibiotic resi...NHGRI targets 12 more organisms for genome sequencing
...iphon pisum); a wasp (Nasonia vitripennis) and two related insect species (Nasonia giraulti and Nasonia longi...comparison with other insects, such as the closely related insect, Rhodnius prolixus. Another insect, the parasitoid wasp Nasonia vitripennis, is a natural en...Remote control flies? Fly behavior controlled by laser light
... study how nerve-cell activity and connections are related to specific behaviors, from simple movements to more complex behaviors like learning, aggression, and even abstract thought. The ability to control specific groups of neurons without implanting electrodes in the brain or using similarly invasive tec...Owl genomics presents a HEPATOCHIP for diagnosis of non-alcoholic steatohepatitis
...ip analyses the co-expression of 85 genes that are related with NASH and is about to be validated in collaboration with the Hepatology Service of Gregorio Marañón Hospital (Madrid). This HEPATOCHIP method determines the co-expression of genes in the liver tissue sample, providing monitoring treatment regime...Bee mites suppress bee immunity, open door for viruses and bacteria
...ls that disinfect the honey and for other immunity related chemicals. They also measured the amount of virus in each bee. Surprisingly, they found that the virus in mite-infested bees rapidly increased to extremely high levels when the bee was exposed to the bacteria. The virus levels in mite-free bees did ...Scientists analyze chromosomes 2 and 4
... the human genome and speed the discovery of genes related to human health and disease. In addition, these findings provide exciting new insights into the structure and evolution of mammalian genomes," said Francis S. Collins, M.D., Ph.D., director of NHGRI, which led the U.S. component of the Human Genome P...Alcohol consumption disrupts breastfeeding hormones
... produced less milk overall, physiological effects related to the alcohol-induced changes in oxytocin. The current research provides a physiological basis for Mennella's previous findings concerning alcohol's effect on breastfeeding. Those studies indicated that infants ingest less milk at the breast in the......explains the evolution of a huge number of closely related fish species on reefs in an open undersea world where currents constantly stir the waters, washing in fish or their larvae from afar, a world without well-defined geographical barriers? Rocha et al. took a close look at the genetics of one group of W...