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Tag: "regulatory" at biology news

Man and mouse share genome structures

...off. Their findings may help scientists understand regulatory mechanisms underlying cancer and human development...s are on." Many scientists believe changes in the regulatory scaffolding surrounding the genome may be as important as changes in the genome itself in causing di...

Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats

...ightness of a light. Co-activators join with other regulatory proteins called transcription factors in controlling the expression of genes. Spiegelman and Jiandie Lin, PhD, the paper's lead author and a researcher at Dana-Farber, have previously discovered the PGC-1 co-activator family and several of its bioche...

Source of molecular triggers in cutaneous T cell lymphoma identified

...cells, after stimulation by LC, become functioning regulatory T (Treg) cells that suppress the immune responses of normal T cells to microbial agents. This may explain the susceptibility of patients with extensive CTCL to opportunistic infections. "Through understanding T cell and dendritic cell interactions, ...

Scientists seek answers on what activates deadly anthrax spores

...ctural Biology, added, "Basic understanding of the regulatory signals that promote germination will enable discoveries leading to drugs that block the process." The research is being paid for by a $152,687 grant from the Southeast Regional Center of Excellence in Biodefense and Emerging Infections, based at Du...

First 'atlas' of key brain genes could speed research on cancer, neurological diseases

...ing of all of the major brain areasthat shows what regulatory genes are expressed in those specificlocations,?said Quifu Ma, PhD, of Dana-Farber’s Cancer BiologyDepartment. He is senior author of a paper appearing in today’s onlineissue of the journal Science, along with Charles D. Stiles, PhD, alsoof Dana-Farb...

Studies reveal methods viruses use to sidestep immune system

... activate a transcription factor called interferon regulatory factor 3 (IRF-3). This protein turns on the genes responsible for producing interferon, which neutralizes viruses by suppressing their replication. The researchers also investigated why cells with functioning RIG-I protein still had persistent HCV i...

An entropy-based gene selection method for cancer classification using microarray data

...ideally identify genes involved in cancer-specific regulatory pathways. Here an entropy-based method is proposed that selects genes related to the different cancer classes while at the same time reducing the redundancy among the genes. Results The present study identifies a subset of features by maximizing th...

Unexpressed But Indispensable -- The DNA Sequences That Control Development

...to spot, the characteristic features of non-coding regulatory elements are largely unknown, making their discovery by simple sequence analysis difficult. In this issue, Greg Elgar and colleagues attack this problem by comparing the non-coding sequences of the human and the pufferfish. Since the last common anc...

Affymetrix and the Karolinska Institutet Announce Translational Medicine Strategic Alliance

...suppliers, uncertainties relating to FDA and other regulatory approvals, competition, risks relating to intellectual property of others and the uncertainties of patent protection and litigation. These and other risk factors are discussed in Affymetrix' Form 10-K for the year ended December 31, 2003 and other SE...

How an AIDS-Related Cancer Unleashes Inflammation

...K2 creates inflammation that in turn activates the regulatory protein p38. p38, in turn, further increases activation of MK2. "We still don't know the mechanism by which kaposin B activates MK2," said Ganem. "Nor do we understand how this activation leads to activation of the upstream regulator of MK2, which i...

Sequencing of marine bacterium will help study of cell communication

...connection between quorum sensing and other global regulatory networks through a combination of comparative genomics and experimental molecular biology. Other researchers are focusing on the relationship between the bacterium and its animal host. The PNAS article concludes, "If we are to understand the unifyin...

Opposing fat metabolism pathways triggered by a single gene

..., from nematodes to humans. Central players in the regulatory network are the nuclear hormone receptors (NHRs), which are transcription factors that turn on or off a set of target genes when bound by specific lipid molecules. In the premier open-access journal PLoS Biology, Keith Yamamoto and colleagues show th...

Insight into natural cholesterol control suggests novel cholesterol-lowering therapy

...g one called HMG CoA reductase, and many layers of regulatory control, said Russell DeBose-Boyd, senior author o...unction by statins also limits the availability of regulatory intermediates that govern reductase activity, contributing to a major increase in active reductase t...

Medical whistleblowers speak out

... explained that the studies that are the basis for regulatory approval are too small and are conducted over too ...t how American medicine - clinicians, researchers, regulatory agencies, and medical journals - can disentangle itself from the influence of the pharmaceutical ind...

Brain Scans Reveal How Gene May Boost Schizophrenia Risk

...ulate. "We expected that there would be different regulatory mechanisms between the two gene types, but it's amazing how well the data support this tuning model," said Berman. "The study is important for our understanding of schizophrenia because it clarifies the neural mechanism for a well-established risk ge...

Live vaccines more effective against horse herpes virus

... the Animal Health Diagnostic Center, the official regulatory diagnostic laboratory for equine diseases in New York state. On May 18, two horses stabled at Churchill Downs showed symptoms of the neurological form of equine herpes and were euthanized, leading to concern at the May 22 Preakness Stakes at Pimlico...

Roche clinical trial registry and results database launched

...ities are performed in accordance with ethical and regulatory requirements. Moreover, Roche is strongly committed to verifying adherence to compliance policies. Adequate and ongoing peer review is a key prerequisite for maintaining high ethical standards in Roche’s clinical trials and development activities. In...

Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression

...s have realized that microRNA is a new category of regulatory molecules and identified hundreds of different microRNA in mammals. The big question was, what are they doing? About a dozen years ago a few studies came out that showed that microRNA could suppress translation in certain Drosophila (fruit fly) gene...

FDA Works To Speed The Advent Of New, More Effective Personalized Medicines

...submissions, and the data that will be used during regulatory decision making. The guidance also explains a new ...ternal, agency-wide group and will not be used for regulatory decision making, will help FDA and industry gain valuable experience as this new field continues to ...

Researchers find promising cancer-fighting power of synthetic cell-signaling molecule

...tosis. Cancer cells are usually defective in these regulatory pathways, so researchers hypothesized that structurally modified sphingolipid analogs might be even better at making cancer cells behave more normally. Merrill and his collaborators have been studying sphingolipids for more than a decade, having fir...

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