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Tag: "regulating" at biology news

Researchers track down cause of a disfiguring bone disorder

...SOST, gene, and showed that it plays a key role in regulating bone formation. The culprit is a regulatory element in a missing 52,000-base-pair stretch of DNA that normally directs the SOST gene to produce a protein that maintains control of bone formation rates. Without this regulator, bone production goes up,...

Missing Receptor Molecule Causes Tumor Growth

...receptor molecule, which is an important factor in regulating cell growth, is missing. In healthy tissue, cells grow and divide - this is also true of cancerous tumors. The difference between the two lies in the regulation, which functions well in healthy tissue, but not in tumors. An important mechanism of th...

Nanoparticles carry cancer-killing drugs into tumor cells

...receptor molecule, which is an important factor in regulating cell growth, is missing. In healthy tissue, cells grow and divide - this is also true of cancerous tumors. The difference between the two lies in the regulation, which functions well in healthy tissue, but not in tumors. An important mechanism of th...

Insulin pulses keep the liver lean

...hat CEACAM1 is at the intersection of the pathways regulating insulin and fat metabolism in liver," Najjar said. "Although mutations in CEACAM1 have not been found in patients with diabetes or insulin resistance, it is tempting to speculate that CEACAM1-dependent inhibition of fatty acid synthesis might be com...

Gene controlling circadian rhythms linked to drug addiction

... found that the Clock gene is not only involved in regulating sleep/wake cycles, but is also very involved in regulating the rewarding responses to drugs of abuse," said Dr. Colleen A. McClung, assistant instructor of psy...

Hormones and growth: The control of body size and developmental growth rate in fruit flies

...land regulates body size and developmental rate by regulating ecdysone release. In the second study, Christen Mirth, James W. Truman, and Lynn M. Riddiford address how developing flies sense that they have reached the proper size to initiate a new phase of development. Their new findings show that the prothora...

Modification of program enables prediction of gene transcription

...n the so-called untranslated region is involved in regulating the gene. Running the modified TWINSCAN, on both the human and fruit fly genomes, Brent and colleagues predicted about 25,000 transcription-start sites, compared with a known 6,000. "In the human genome, we found many extra exons on genes that were ...

Clear rules needed to govern deep sea bioprospecting: UNU

...eir waters and seabed, only a few have legislation regulating access to and exploitation of their marine and other genetic resources. Many of the world's unique seabed ecosystems lie in international waters beyond national jurisdiction with no international rules. And no state has yet adopted measures addressi...

A Father’s Day Gift: Free DNA Paternity Testing

...eir waters and seabed, only a few have legislation regulating access to and exploitation of their marine and other genetic resources. Many of the world's unique seabed ecosystems lie in international waters beyond national jurisdiction with no international rules. And no state has yet adopted measures addressi...

Muscle repair: Making a good system better, faster; implications for aging, disease

...nesis directly, PAI-1 may modulate regeneration by regulating the inflammatory response (and) may also modulate ...egulation of extracellular matrix turnover (or) by regulating the bioactivity of a variety of growth factors." Role of macrophages likely important Confirming e...

Tadpole soon to help in the fight against cancer and lymphedema

...etwork is of major importance. It is essential for regulating fluid in the body and for the support of the immune system that protects us from pathogenic organisms. Faults in the making or functioning of this network cause many disorders, such as inflammatory and infectious diseases and lymphedema (a swelling c...

Molecular mechanism of feather formation found

...velopment. To assess the specific role of Bmp2 in regulating Shh expression, Harris tricked the cells into believing that Bmp2 was signaling them continuously by altering receptors in the cells. The over-expression of Bmp2 signaling via the altered receptors led to ongoing down-regulation of normal Shh express...

Water management in cells

Water management is the key to regulating cell volume says Dutch researcher Bas Tomassen. He investigated the uptake and secretion of water by the plasma membrane of animal and human cells. Cell volume is the outcome of a subtle balance between water uptake and secretion by the cell plasma...

Micro RNAs play role in egg making

...alled microRNAs (miRNAs) play an important role in regulating oogenesis, the process by which females make eggs. MiRNAs silence genes by binding to genetic elements called messenger RNA and preventing them from making new proteins -- the molecules primarily responsible for cell activities. While previous resea...

New study finds how cells with damaged DNA alert the immune system

...mation about the role of the DNA damage pathway in regulating immune responses to infectious diseases, but given what we have shown here, it is certainly plausible that it contributes to the expression of the NKG2D ligand," said Raulet. "It may also be that the Rae1 ligand helps trigger T cell responses that co...

Renewed hope for Parkinson's patients

...mation about the role of the DNA damage pathway in regulating immune responses to infectious diseases, but given what we have shown here, it is certainly plausible that it contributes to the expression of the NKG2D ligand," said Raulet. "It may also be that the Rae1 ligand helps trigger T cell responses that co...

Scientists get first glimpse at how plants, most animals repair UV-damaged DNA

...xpected: Water plays a key role in the process, by regulating how long the donated electron stays inside the damage site before returning to the photolyase molecule. Scientists believe that all placental mammals lost the ability to make this enzyme some 170 million years ago, said Zhong, an assistant professor...

Newly recognized gene mutation may reduce seeds, resurrect plants

...uence how seeds develop, perhaps playing a role in regulating the number of seeds a plant will support to maturity," Jenks said. "Seed abortion by plants likely is a tightly regulated process that necessitates allowing some seed loss to conserve resources in a stressful environment without aborting all seeds, w...

Purdue researchers find key to rice blast fungus

...st fungus has more than 40 GPCRs that probably are regulating the signals at the beginning of the penetration pathway. "We are working on the basic infection process," Xu said. "We want to know what genetic mechanisms regulate this process, how the fungus spores recognize the plant surface, and how they know t...

Human brain is still evolving

...ca." While the roles of Microcephalin and ASPM in regulating brain size suggest that the selective pressure on the new variants may relate to cognition, Lahn emphasized that this possibility remains speculative. "What we can say is that our findings provide evidence that the human brain, the most important org...

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