regulates 2 9

Tag: "regulates" at biology news

Does a peptide affect the heart's response to social isolation?

... of oxytocin, a peptide produced by the brain that regulates social behavior, has found that it can prevent detrimental cardiac responses in adult female animals exposed to social isolation. The findings may provide further insight into how these mechanisms affect humans. The study was conducted by Angela J....

New insights into autoimmunity and depression

...aining pattern delineated the limbic system, which regulates the automatic nervous system’s response to stress. It also highlighted areas of the brain associated with the sense of smell. These findings provide a novel line of research into the mechanisms underlying the limbic and olfactory pathways in depre...

Protein found that slows hepatitis C growth in liver cells

...dings reveal a novel cellular control pathway that regulates the growth of hepatitis C virus within the cell,?said Dr. Stanley M. Lemon, director of the National Institutes of Health-funded Hepatitis C Research Center at UTMB and of the academic medical center’s Institute for Human Infections and Immunity. Lem...

Linheng Li Lab documents the development of cancer stem cells

...leted. They found that the PTEN/Akt pathway likely regulates stem cell activation by helping control nuclear localization of beta-catenin, the Wnt pathway effector, through phosphorylation of beta-catenin -- including Serine552. "We found that a loss of PTEN in intestinal epithelial cells accompanied by a...

MicroRNA helps prevent tumors

A microRNA directly regulates a gene implicated in human cancers, researchers from Whitehead Institute and Massachusetts Institute of Technology report in the February 22nd online issue of Science. MicroRNAs are tiny snippets of RNA that can repress activity of a gene by targeti...

Protein key to organ growth

...ly involved in regulating Rheb function so that it regulates cell size as well as cell numbers. We found that in the case of dysfunction, the eyes and wings get smaller," said Choi. "If you completely knock out this function in the eye, they have no eyes." TCTP was of interest because it is over-expressed o...

Brain networks strengthened by closing ion channels

...d DISC1 (Disrupted in Schizophrenia) that normally regulates cAMP. Loss of function of DISC1 in patients with schizophrenia or bipolar disorder would increase vulnerability to cortical network disconnection and profound PFC deficits. This may be especially problematic during exposure to even mild stress, which...

Scientists map key landmarks in human genome

... other genes. "We wanted to understand how MITF regulates target genes, and specifically where in promoter regions of those genes does MITF bind," Fisher said. "In the process of this work, we asked whether MITF is binding between nucleosomes or on top of nucleosomes, and that led us to devise a method to a...

Twin studies reveal genetic components leading to cardiac and kidney disease

...alled endothelin (ET-1), is trigged by a gene that regulates catecholamines, chemical compounds produced in the adrenal gland that are released in reaction to stress. The study measured the plasma concentration of ET-1 in about 300 twins. The results establish and verify a previously unsuspected link between c...

Elucidation of the genome for diabetics with DNA chips

...l organs, including the pancreas. This enzyme also regulates Wnt signalling. Finally, the SLC30A8 gene encodes the ZnT8 protein, which is involved in zinc transport. This protein is involved in insulin binding in the pancreas. According to the work of the French team directed by P. Froguel and Mellitech, a ...

Angelman syndrome deficits rescued in mice

... is a "housekeeping" gene, meaning that it broadly regulates cellular processes not particularly specific for any of the neurological deficits seen in these children. Specifically, the protein encoded by UBE3A "tags" other proteins for degradation by the cellular "garbage disposal," the proteasome. "The mos...

Technology reveals 'lock and key' proteins behind diseases

...s discovered that one of these interactors, Tus1p, regulates Ycf1p transporter function in a completely novel way to stimulate its ability to remove toxins from the cell. "The more we learn about membrane proteins, the better we can use this knowledge for pharmacological and clinical applications," Staglja...

Bacteria control how infectious they become, study finds

..., a microorganism will die. “We think that NusG regulates nearly every gene in every form of bacteria,?said Irina Artsimovitch, the study's lead author and an associate professor of microbiology at Ohio State . “Say a bacterium has 3,000 genes ?NusG would regulate 2,900 of them.? But somewhere along the e...

Gene elevating breast cancer risk also causes prostate cancer

...dentified a novel BRCA2 binding factor, PALB2 that regulates certain key functions of normal BRCA2 activity. The next step was to set out to evaluate the newly detected PALB2 gene as a potential heritable breast cancer susceptibility candidate by screening for disease-related alterations. The results of this i...

Scientists find hormone activity explains adolescent mood swings

...the onset of puberty in the part of the brain that regulates emotion. Paradoxically, THP reduced the inhibition produced by these alpha4-beta2-delta GABA-A receptors, increasing brain activity to produce a state of increased anxiety. Stress also increased anxiety at puberty, due to the paradoxical effects of t...

How appetite-stimulating brain cells work overtime during fasting

...mechanism involved is very similar to the one that regulates core body temperature in peripheral body tissues, Diano added. Thyroid hormones are known to play major roles during development as well as in adulthood, the researchers said. In adults, the thyroid gland is essential to regulating metabolism. Pre...

Brain's reward circuit activity ebbs and flows with a woman's hormonal cycle

...he amygdala and a cortex area behind the eyes that regulates emotion and reward-related planning behavior more during the pre-ovulation phase (four to eight days after their period began) than in the post-ovulatory phase. When they hit the jackpot and actually won a reward, women in the pre-ovulatory phase...

Out-of-body experiences may be caused by arousal system disturbances in brain

...hat phenomena in the brain's arousal system, which regulates different states of consciousness including REM sleep and wakefulness, may be the cause for these types of out-of-body displays. "We found it surprising that out-of-body experience with sleep transition seemed very much like out-of-body experience...

Leukemia drug turns mini-molecules up, cancer genes down

...expression of these three miRNAs, and through them regulates genes that need to be silenced for the cell to differentiate." ...

Fast and slow -- How the spinal cord controls the speed of movement

...s have found a surprising pattern of activity that regulates the speed of the fish’s movement. The research may have long-term implications for treating injured human spinal cords and Parkinson’s disease, where movements slow down and become erratic. The study, "A Topographic Map of Recruitment in Spinal Cord...

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