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Tag: "regulates" at biology news

PTEN: the Treg's handbrake

... These results identify PTEN as a key protein that regulates the lack of responsiveness of Tregs to IL-2 and could provide researchers with a way to overcome one of the biggest obstacles to harnessing their therapeutic potential. ...

Researchers uncover new mechanism of tumor suppressor

...growth 2 tumor suppressor recognizes chromatin and regulates cell growth, proliferation, stress responses and aging. We hope this discovery opens up new opportunities to establish novel targets to prevent and treat cancer," said Kutateladze, a NARSAD Young Investigator and an American Cancer Society Research S...

Cells use mix-and-match approach to tailor regulation of genes

...xperimental evidence that indicates that that gene regulates a second gene. To enlarge the scope of the model further, Ideker's group also incorporated other previously discovered transcription-factor interactions and related genetic results. They relied on a total of eight types of direct and indirect eviden...

New stem-cell findings can help the body to cure itself

...itutet have identified an important mechanism that regulates how many new cells are produced by each intestinal...have identified a signal transduction process that regulates the degree of stem-cell division. "Understanding how cell production is regulated increases our cha...

Plant protection from cold decoded

... described how a little-known biochemical reaction regulates that genetic cascade. Zhu's findings were published in the May 15 online version of the Proceedings of the National Academy of Sciences in a paper titled The Negative Regulator of Plant Cold Responses, HOS1 is a RING E3 Ligase That Mediates the Ubiq...

Neural stem cell gene plays crucial role in eye development

...l stem cell gene, SOX2, are a critical factor that regulates the differentiation of neural stem/progenitor cells in the eye. Their work appears in the current edition of the journal Genes & Development. The SOX2 gene is a member of class of master genes that encode for transcription factors. Transcripti...

Loosen up, DNA: Leukemia gene changes genetic packaging

...in any given cell at any one time. How our body regulates access to our genes and makes stretches of DNA available is a booming area of study for scientists who study "chromatin remodeling." When a gene is spooled up tightly, it's as if it has been confined by a straightjacket ?it's unavailable or "silenced...

Compound in dairy products targets diabetes

... of the protein, which then interacts with DNA and regulates gene expression. This increases the enzymes that process fatty acids and also increases the tissues' sensitivity to insulin. "We wondered if CLA was using the same mechanism, in which case it could be used as an anti-diabetes drug," Vanden Heuv...

UCLA study finds same genes act differently in males and females

...e genetic code, but our findings imply that gender regulates how quickly the body can convert DNA to proteins," said Yang. "This suggests that gender influences how disease develops." The gender differences in gene expression also varied by tissue. Affected genes were typically those most involved in the or...

Scientists tie several cancers to common 'oncogene engine'

...dentified some of the genes and proteins that MITF regulates that new drugs could be used to block. One of the targets is Bcl-2, which enables cancer cells to survive when the body has ordered them to self-destruct, and another is CDK-2, a protein that is often abnormal in cancer. Related to MITF in the MiT t...

No cell walls, no new cancer cells

...ar we discovered that a protein called SREBP1 that regulates the synthesis of lipids needed for new cell walls was regulated during the cell cycle. Now we show that the SREBP1 protein actually controls the cell cycle." Senior author, LICR's Dr. Johan Ericsson, realized that disrupting the function of SREBP1 ...

Green tea and the 'Asian Paradox'

...G also reduces the amount of platelet aggregation, regulates lipids, and promotes proliferation and migration of smooth muscle cells, which are all factors in reducing cardiovascular disease, he said. Sumpio said other reports show that EGCG prevents growth of certain tumors. Tea, according to studies, also ...

No-mow grass may be coming to your yard soon

...e mapped a critical hormone signaling pathway that regulates the stature of plants. In addition to lawns that r...g pathway for a key class of steroid hormones that regulates growth and development in plants. "By manipulating the steroid pathway…we think we can regulate pl...

New angiogenesis finding may help fight cancer growth

...enesis. Instead, they were studying a protein that regulates the maturation of blood cells, and noticed that it...e to call it a master switch, but intriguingly, it regulates at least four different processes, each of which individually would be anti-angiogenic," says Bresni...

Scientist works to improve treatment for brain tumors

...receptor for interleukin 13 (IL13), a protein that regulates the immune system. Debinski combined IL13 with a bacterial toxin to create a cytotoxin drug to target cancer cells and less healthy cells. The efficacy of the first generation of the drug has been has been tested in a clinical trial (phase III) invol...

New mechanism explains glucose effect on wakefulness

...ttle about how the basic energy molecule, glucose, regulates such wakefulness and other energy-related behaviors. Now, in an article in the June 1, 2006, Neuron, Denis Burdakov of the University of Manchester and his colleagues have pinpointed how glucose inhibits neurons that are key to regulating wakefulnes...

Jefferson scientists identify gene mutation potentially involved in breast cancer initiation

...nti suggests, could act as a kind of "switch" that regulates receptor activity and cell proliferation. "It is the first time that we can say that the loss of function of caveolin gene expression plays a role in the specific upregulation of estrogen receptor," he says. "It helps explain the nature of this tran...

How does a zebrafish grow a new tail?

... communication, called Wnt/Beta-catenin signaling, regulates the fate of these as-yet undeveloped cells as an embryo forms. Through a cascade of signals, cells waiting for their calling learn which spot to take to help form the embryo, what kinds of cells to become there, and how many cells like themselves sho...

New path from estrogen to survival in breast cancer cells described

...roteins, the researchers say. "NEDD8 modified BCA3 regulates the activity of NFkB, but BCA3 alone does not have any impact on NFkB," says Yeh. Then they looked at how this NEDDylation further works to suppress the ability of NFkB to transcribe (activate) other genes. Here the investigators found SITR1, the m...

Molecular 'on/off switch' controls immune defenses against viruses

...s of each protein. The domain is the key site that regulates the ability of RIG-I to bind to its signaling partners, including LGP2, acting as a switch for controlling immune response, Dr. Gale said. "Hepatitis C and others viruses hijack this signaling pathway to stop immune defenses," he said. His rese...

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