A new molecule discovered in the battle between plants and disease
...University Title: A novel peptide signal, AtPep1, regulates pathogen defense in Arabidopsis AtPep1 is a 23 amino acid peptide that was isolated from Arabidopsis thaliana (G. Pearce, A. Huffaker, C.A. Ryan, submitted). The peptide is encoded by a gene at the locus At5g64900 and is derived from the carboxyl te...Gene controlling circadian rhythms linked to drug addiction
The gene that regulates the body's main biological clocks also may play a ...n researchers showed that, in mice, the Clock gene regulates the reward response to cocaine, suggesting that similar actions take place in humans. Findings from ...MicroRNA tweaks protein that controls early heart development
...roRNAs are a common mechanism through which a cell regulates itself at various stages, both during development and later in life," he said. "This is a rapid way to regulate protein levels. You can imagine a pool of messenger RNA ready to make a protein, and by virtue of a microRNA, that protein synthesis can i...Discovery of T-cell 'traffic control' boosts new drug promise
...T cell trafficking. Goetzl has also shown that S1P regulates T cell trafficking by occupying a receptor on the T cell surface that suppresses the cells' normal response to a "forward march" signal. T cells respond by chemotaxis -- moving from areas of lower to higher concentration of a signaling molecule know...Duke Experiments Boost Radiation's Cancer-Killing Effects
.... Yet its impact on cancer cells is so diverse ?it regulates more than 70 genes -- that simply blocking its activity without regard to its myriad effects has yielded conflicting results. Some of HIF-1's effects promote cancer, while others inhibit cancer, so it is critical to block the protein at a juncture wh...Brain size may depend upon how neural cells are cleaved
...known about the molecular signaling mechanism that regulates the decision to cleave one way or another, said Tsai. Studies in fruit flies and roundworms had hinted that major regulatory molecules called heterotrimeric G proteins play a role in orienting the mitotic spindles that govern the orientation of cell...IBM Transforms the Art of Scientific Expeditions
.... Yet its impact on cancer cells is so diverse ?it regulates more than 70 genes -- that simply blocking its activity without regard to its myriad effects has yielded conflicting results. Some of HIF-1's effects promote cancer, while others inhibit cancer, so it is critical to block the protein at a juncture wh...How cell suicide protects plants from infection
Researchers at Yale have identified a gene that regulates the major immune response in plants, programmed cell death (PCD), according to a recent report in the journal Cell. To protect themselves from viruses, plants create a zone of dead cells around an infection site that prevents the infection from spre...Hormones and growth: The control of body size and developmental growth rate in fruit flies
...onclude that Ras activity in the prothoracic gland regulates body size and developmental rate by regulating ecdysone release. In the second study, Christen Mirth, James W. Truman, and Lynn M. Riddiford address how developing flies sense that they have reached the proper size to initiate a new phase of develop...Life-extending protein keeps blood sugar in check
..., they reported. Further analyses found that Sirt1 regulates genes involved in insulin secretion by b cells. "Together, these results establish that an increase dosage of Sirt1 has beneficial effects on mammalian physiology," Imai said. "Our findings also provide new insight into the physiological and molecul...Sea Ice May Be on Increase in the Antarctic
..., they reported. Further analyses found that Sirt1 regulates genes involved in insulin secretion by b cells. "Together, these results establish that an increase dosage of Sirt1 has beneficial effects on mammalian physiology," Imai said. "Our findings also provide new insight into the physiological and molecul...Weight control protein may yield antiobesity drugs
...ey found. The current study shows that SH2-B also regulates energy balance and body weight by enhancing leptin sensitivity in animals, Rui said. Mice lacking a functional copy of the SH2-B gene were smaller at birth than normal mice. After 5 weeks of age, however, the mice began gaining weight rapidly and we...Scientists uncover new clues about brain function in human behavior
...r-time because it may be the only thing that still regulates the amygdala in Williams Syndrome." ......n's central timekeeper - the biological clock that regulates waking and sleeping cycles - has two parts that fall out of synchrony during light schedule shifts of six hours, the time it takes to fly across the Atlantic. The finding may explain, at least in part, why transmeridian travelers suffer from jet lag...Identical twins may have more differences than meet the eye
... gene expression," he said. "If we understand what regulates methylation patterns, then we may be able to develop better treatment options for cancer." The researchers received financial support for this work from the Foundation of the Spanish Association Against Cancer. Plass, Yu and Esteller conducted the ...Computer modeling reveals hidden conversations within cells
...ecules in the "NF-kappaB signaling pathway," which regulates genes involved in cancer, inflammation, immune function and cell death. Each equation takes into account a different parameter, such as how quickly a protein is synthesized, or how quickly it is degraded. The researchers chose the NF-kappaB protein...Scientists find evidence of catastrophic sand avalanches, sea level changes in Gulf of Mexico
... gene expression," he said. "If we understand what regulates methylation patterns, then we may be able to develop better treatment options for cancer." The researchers received financial support for this work from the Foundation of the Spanish Association Against Cancer. Plass, Yu and Esteller conducted the ...... hippocampus, an area buried in the forebrain that regulates emotion and memory, as the origin of fear memory. "This is critical as it changes how and where scientists thought fear was developed," says Zhuo, the EJLB-CIHR Michael Smith Chair in Neurosciences and Mental Health. "By understanding the biomolecu...Enzyme affects hypertension by controlling salt levels in body
...ang joined efforts with Dr. Cobb to study how WNK1 regulates sodium channels. "We have been working on WNK1 for several years now and these findings are unexpected from initial studies," said Dr. Cobb. "What is particularly satisfying and exciting is the ease with which we could establish such a collaboration......called a "nuclear transcription factor" because it regulates the transcription of its target genes in cell nucl...es. "As p53 is a nuclear transcription factor that regulates various mitochondrial genes and insofar as mitochondrial dysfunction appears important in HD, our fi...