Epstein-Barr virus protein crucial to its role in blood cancers
...fic viral protein targets a molecule that normally regulates the cell-cycle progression, or duplication process, of resting B cells. In the presence of this viral protein ?called EBNA3C (for EBV nuclear antigen) ?the cell cycle of the usually quiescent human B cells gets a jump start, which ultimately initiate...Defensins neutralize anthrax toxin
...fic viral protein targets a molecule that normally regulates the cell-cycle progression, or duplication process, of resting B cells. In the presence of this viral protein ?called EBNA3C (for EBV nuclear antigen) ?the cell cycle of the usually quiescent human B cells gets a jump start, which ultimately initiate...50-year-old Mystery Solved: Protein Tags Regulate Key Ion Channel
...us -- also occurs near the cell's surface where it regulates at least one and possibly many kinds of proteins, providing a novel target for the development of new drugs. The discovery, published in the 8 April 2005 issue of the journal Cell, answers a question dating back to the 1950s: How do cells control th...Gene therapy promising for growing tooth-supporting bone
...years. BMP-7 is part of a family of proteins that regulates cartilage and bone formation. Recent studies have shown that BMPs are present in tooth development and periodontal repair. This study mixed BMP-7 genes with an inactivated virus in a gel-like carrier and injected it into wounds. Giannobile said usin...Scientists identify molecule that regulates well-known tumor suppressor
...e phosphatidylinositol 3' kinase signaling pathway regulates cell growth and survival, and is inhibited by acti...is. "Our results demonstrate that DJ-1 negatively regulates PTEN function, and that this cell survival control mechanism is conserved among various tissues and ...Discovery may lead to better Candidiasis drug
...to a specific membrane protein called TRK1p, which regulates potassium ion flow through the cell membrane of th...nternal and external environments, which, in turn, regulates their volume and water content. Cells that lose their water content without being able to regulate i...UCSD research reveals mechanism involved with type of fatal epilepsy
...e of 30, can be caused by mutations in a gene that regulates the concentration of the protein laforin. These fi...d that malin physically interacts with laforin and regulates laforin's concentration by marking it for degradation. Their results show that approximately 40 perc...UN environmental agency steps up battle against marine pollution
...ent of hazardous and other wastes. The Convention regulates the movement of hazardous waste and obliges its members to ensure that such wastes are managed and disposed of in an environmentally sound manner. It covers toxic, poisonous, explosive, corrosive, flammable, ecotoxic, and infectious wastes that are b...Newly discovered protein an important tool for sleeping sickness research
...iation. With the goal of learning how the organism regulates the process of antigenic variation, the scientists have been trying to understand how the trypanosome makes base J. The discovery of JBP2, a member of a protein family that helps control DNA-related functions, is a significant breakthrough in this q...Disabling gene defuses rheumatoid arthritis in mice
...enes belong to the forkhead family of genes, which regulates the activity of other genes and has been connected to cancer and longevity. Last year Peng found that knocking out Foxj1 produced a lupus-like condition in mice. Foxj1 and Foxo3a are thought to play similar roles in immune T cells. To get a better s...Breakthrough System for Understanding Ocean Plant Life Announced
...iation. With the goal of learning how the organism regulates the process of antigenic variation, the scientists have been trying to understand how the trypanosome makes base J. The discovery of JBP2, a member of a protein family that helps control DNA-related functions, is a significant breakthrough in this q...Understanding how bacteria communicate may help scientists prevent disease
...ulkarni said. A third question is how the circuit regulates important biological processes, such as biofilm formation and virulence. "Biofilms make bacteria resistant to antibiotics, so preventing the formation of biofilms or short-circuiting bacteria's ability to become virulent by disturbing their communica...Enzyme's newly discovered role may make it target for arthritis treatment
...t. Louis shows that an enzyme known as cathepsin G regulates the ability of immune cells known as neutrophils t...M, Cheng AM, Pham CTN. Serine protease Cathepsin G regulates adhesion-dependent neutrophil effector functions by modulation integrin clustering. Immunity, June 7...Study finds adult stem cells can replicate
...t. Louis shows that an enzyme known as cathepsin G regulates the ability of immune cells known as neutrophils t...M, Cheng AM, Pham CTN. Serine protease Cathepsin G regulates adhesion-dependent neutrophil effector functions by modulation integrin clustering. Immunity, June 7...The making and breaking of microtubules
...ucleotide-dependent bending flexibility of tubulin regulates microtubule assembly," by Hong-Wei Wang and Eva Nogales, appears in the 16 June 2005 issue of Nature. ...Study: Well-known protein helps stem cells become secretory cells
... researchers have discovered that a single protein regulates secretion levels in the fruit fly's salivary gland and its skin-like outer layer. Described in the May 15 issue of Development, the finding improves understanding of how cells become specialized for secretion, which is a critical ability of certain ...UCR chemist part of team identifying new areas of gene regulation
...g the nucleosome remodeling complex SWI/SNF and so regulates gene activity," he said. "We show for the first time that a modification of a histone at the core of the protein, not the end, can regulate genes," Grunstein added. ...Bioinformatics reveals new gene regulation system
...es where the NrdR-box occurred. They found that it regulates other genes related to DNA replication, such as the enzymes that cut, paste, and untangle new DNA as it is synthesized, and enzymes that are involved in recycling nucleotide building blocks. Although the work does not have direct application to huma...Snapin: A protein with therapy potential for autism
... has worked extensively with cypin, a protein that regulates dendrite numbers (a news release is posted online ...enter. "Our pathway says cypin does this; now what regulates cypin? Here snapin has a role. And what does snapin regulate?" said Firestein. "Our hope is in ten y......gene called MFRP that helps control eye growth and regulates the organ's shape and focus. The study is described in the July 5 issue of the Proceedings of the National Academy of Sciences. "The MFRP protein is only made in a tiny portion of the human eye, and it can alter eye refraction, or focus," said Olof ...