Parasitic worms used to fight bowel disease
...d in a way that is dependent on parasitic worms to regulate immune responses." The particular worm that Mansfield and colleagues are studying as a potential treatment is known as the whipworm, or Trichuris suis, which is a parasite that afflicts pigs. Early studies have shown that giving humans a concoction ...Researchers map out networks that determine cell fate
A two-step process appears to regulate cell fate decisions for many types of developing c...ity of Chicago, "and we suspect such networks also regulate cell fate in other systems." This finding "represents a significant advance in understanding the mo...New pathways for autoimmune treatment identified
...too hard, it can induce autoimmune disease. If you regulate suppression too hard, you can get cancer. i NKT cells help maintain a healthy balance. But patients with autoimmune disease may not have enough functional iNKT cells." "Aire controls the development and function of i NKT cells," says Drs. Jin-Xio...Pigeons provide clue to solving common problem in heart patients
...'s group focused on "transcription factors," which regulate whether a gene is expressed and at what rate. The group's aim was to see if certain transcription factors might be found in altered amounts in the smooth muscle cells of pigeons that are prone to atherosclerosis. They screened 54 different transcr...First direct mechanical communication of mitochondria, cardiomyocyte nucleus shown
...ion, suggesting that mitochondria may mechanically regulate nuclear function." The team, which has been colla...ion, suggesting that mitochondria may mechanically regulate nuclear function." Next steps Veksler said one idea that needs to be checked out is: If this mec...Researches discover gene critical for protection against septic-shock-induced death
...rchers have been hunting for novel host genes that regulate inflammation as potential targets for the next generation of sepsis therapies. The incidence of sepsis in the United States ranges from 400,000 to 750,000 cases per year. Mortality due to sepsis is around 30 percent and increases with age from 10 per...Marrow-derived stem cells deliver new cytokine to kill brain tumor cells, offer protection
...ells to transport several cytokines ?proteins that regulate immune responses ?to track down and destroy glioma cells. In 2002, the scientists reported that they had produced central nervous system cells from stem cells derived from bone marrow. Because these stem cells originate in the bone marrow instead of...Vegetables inhibit growth of prostate cancer in mice with human tumors
...cent in Laysan albatrosses. Many countries do not regulate the manufacture and use of PCBs and DDT as strictly as the United States does now, and these compounds continue to be released into the marine environment. "The increases we saw compared with ten years ago probably reflect the ongoing use of these ...Albatross study shows regional differences in ocean contamination
...cent in Laysan albatrosses. Many countries do not regulate the manufacture and use of PCBs and DDT as strictly as the United States does now, and these compounds continue to be released into the marine environment. "The increases we saw compared with ten years ago probably reflect the ongoing use of these ...Fish on acid: Hagfish cope with high levels of CO2
...ing because it turns out that Hagfish can not only regulate their acid-base balance, but that they have a grea...e fish (known as osmoconformers) could only poorly regulate their pH. The scientists next want to find the mechanisms by which they do this, and if prolonged e...AIDS-related cognitive impairment exists in two separate forms
...hich are tiny snippets of single-stranded RNA, can regulate the expression of genes, and thus regulate protein synthesis that affects cellular pathways. Because of this ability to regulate gene expressio...Markers of gene, protein, or micro-RNA activity predict outcome in prostate and colorectal cancers
...hich are tiny snippets of single-stranded RNA, can regulate the expression of genes, and thus regulate protein synthesis that affects cellular pathways. Because of this ability to regulate gene expressio...Hepatitis C therapy: Inhibiting newly discovered microDNA molecule
... or miRNAs for short, are small RNA molecules that regulate genes in many plant and animal species. Although miRNAs were not discovered until the mid-1990, a growing number of studies suggest that over 300 human genes encode microRNAs and that these microRNAs may control gene expression for as much as a thir...Study fishes out new role for prostaglandins
...naling in colon cancer. Knowing how prostaglandins regulate cell movement in development can help cancer researchers determine how cancer cells spread throughout the body, or metastasize ?and how to stop the process. DuBois previously found that adding PGE2 to cultured cancer cells causes them to move much mo...Proteins stop blood-vessel and tumor growth in mice
... "Healthy humans produce fibulin proteins, which regulate cell proliferation, migration and invasion. In the past, we have seen that they are depleted in numerous metastatic cancers, and that they inhibit the formation of new blood vessels in cell culture," said William Schiemann, Ph.D., Assistant Professor...Protein found to control tumor growth in certain breast cancers
...ffer the first real evidence that this pathway may regulate tumor growth and suggest a potentially new mechani...on to Nod1," Ulevitch said, "namely its ability to regulate the growth of estrogen-sensitive tumors formed by specific cell lines in immune deficient mice. The...New weapon in battle against osteoporosis
...creases by almost 50 per cent." Signal molecules regulate bone density Together with a research group from...ocannabinoids being formed by the body are able to regulate bone growth. This thesis has been supported by experiments on mice whose ovaries were removed. The ...Study finds 60 new genes controlled by DNA snippet
...e regulome, the complete set of DNA sequences that regulate the behavior of genes. DNA segments that code for ...e Human Genome Project to find all CArG boxes that regulate genes. The sheer amount of information involved requires that such studies use high-powered computer...New Research Shows Artificial Light at Night Stimulates Breast Cancer Growth in Laboratory Mice
...s production of melatonin, a hormone that helps to regulate a person’s sleeping and waking cycles. The new study shows that melatonin also plays a key role in the development of cancerous tumors. “We know that many tumors are largely dependent on a nutrient called linoleic acid, an essential fatty acid, in o...Chemical signaling helps regulate sensory map formation in the brain
... brains," he said. Similar systems are thought to regulate other sensory systems -- such as hearing and touch, as well as motor systems -- but the visual system has been the predominant model system for studying the development of such maps and the gradients of guidance molecules that control their formation...