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Tag: "regulate" at biology news

A genetic 'gang of 4' drives spread of breast cancer

...lloproteinases 1 and 2, were already known to help regulate growth and remodeling of blood vessels, said Massagué. "Our understanding of the genes for these four proteins and their behavior in metastasis led us to hypothesize that they might be cooperating with each other in a way that would give an advanta...

Link found between immune system and high plasma lipid levels

...vels were lowered again. Two organs believed to regulate lipid levels are the liver and the intestine. Researchers looked at the mouse livers ?particularly at the enzyme, hepatic lipase. This enzyme is made in the liver and secreted into the blood where it plays a key role in lipid metabolism. The livers...

Bacteria control how infectious they become, study finds

...ate . “Say a bacterium has 3,000 genes ?NusG would regulate 2,900 of them.? But somewhere along the evolutio...aid. “It seems that the only genes that RfaH can't regulate are those controlled by NusG.? Bacteria can survive without RfaH, but not without NusG. Yet withou...

Technology reveals 'lock and key' proteins behind diseases

... another, it is safe to assume they participate or regulate the same cellular process," explains Stagljar. "Identifying new interactors for ABC transporters may reveal unanticipated aspects of how these transporters function and help researchers gain clues for fighting disease and drug resistance." Using...

New cell type identified in cancer development

...ents revealed that the piwil2 gene may exclusively regulate the process of pCSC development. Gao says these data suggest some important characteristics of pCSCs. "First, it appears that pCSCs require some sort of signal, or cue, from their immediate environment that directs them to become benign or mal...

Gene that makes people 'early to bed and early to rise' demystified

...arge of the residue, alters the ability of PER2 to regulate its own transcription. PER2 presumably manages such regulation through interaction with other proteins since it doesn't bind DNA itself, they said. The findings led the researchers to suggest a model of clock function in which cells sense changing...

Genes and biomarkers that allow doctors to choose the right therapy for the right patient

...Mousses said. To search for target genes that regulate Tykerb response, Mousses and his colleagues performed a genome-scale scan of two cancer cell lines using high-throughput RNAi, "interfering" RNA strands that bind to and knock out one gene individually, across the genome. It is a systematic and highl...

Researchers first to map gene that regulates adult stem cell growth

...This particular gene is important because it helps regulate the number of adult stem cells in the body, particularly in bone marrow. Now that it has been identified, researchers hope the gene, along with its protein product Latexin, can be used clinically, such as for ramping up the stem cell count in cancer...

Growth hormone is not the anti-aging bullet for healthy adults

..., a protein produced by the pituitary gland, helps regulate growth during childhood and metabolism in adults. In the United States, the FDA has approved the drug, now produced synthetically, to treat children with short stature and some other growth problems caused by childhood diseases. The FDA has ap...

Xie Lab demonstrates the role of microRNA pathway

...re single-stranded small RNA molecules believed to regulate the expression of other genes. The Xie Lab's findings show that the microRNA pathway is essential for controlling self-renewal of two types of stem cells in the Drosophila ovary. "The findings were interesting to us because they demonstrated that...

Scientists map key landmarks in human genome

...be packed tightly into a cell's nucleus. They also regulate gene expression, or activity, by determining wheth... by transcription factors, allowing the factors to regulate expression of a nearby gene. It has long been assumed that these factors can't bind to a stretch ...

New cigarette designs don't offer lower predicted cancer risks

... Food and Drug Administration should be allowed to regulate cigarettes. "Marketing claims need to be tightly regulated. Tobacco companies should not be allowed to make expressed or implied promises that can't be completely supported," Pankow said. ...

Protein found to shield pancreatic cancer cells from self-destruction

...ent of a prominent molecular pathway also known to regulate autophagy called the mammalian target of rapamycin. "Targeting TG2, or its activating protein PKC, or both, presents a novel and potentially effective approach to treating patients with pancreatic cancer," Lopez-Berestein said. Research in the mou...

Re-analysis of cigarettes confirms tobacco companies increased addictive nicotine 11 percent

...nd bring the tobacco industry under the rules that regulate other manufacturers of drugs." Beginning in 1997, Massachusetts regulations have required an annual report to be filed with the MDPH by all manufacturers of cigarettes sold in Massachusetts. The reported data include machine-based measures of nico...

Scientists map air pollution using corn grown in US fields

...ions are facing increasing pressure to monitor and regulate the release of carbon dioxide from fossil fuel sou...s and changes in the atmosphere in order to better regulate fossil fuels," said Susan Trumbore, also a professor of Earth system science and co-author of the st...

Scientists unravel clue in cortisol production

...he brain and the endocrine system work together to regulate health, appears in the February issue of the journal Molecular Endocrinology. Turning cholesterol into the stress hormone cortisol involves many reactions and begins when the hypothalamus sends a signal to the adrenal glands. Proteins then flood i...

MicroRNA helps prevent tumors

...ds in humans. Moreover, microRNAs found in mammals regulate over a third of the human genome, as shown in a 20...ion in the gene disrupts the microRNA's ability to regulate it. In addition, the results show that the interaction of one microRNA with one of its target genes ...

Cracking open the black box of autoimmune disease

...id arthritis occur when the immune system fails to regulate itself. But researchers have not known precisely where the molecular breakdowns responsible for such failures occur. Now, a team of scientists from the Whitehead Institute and the Dana-Farber Cancer Institute have identified a key set of genes that l...

How stem cells are regulated

...hagen have identified a new group of proteins that regulate the function of stem cells. The results are publis...ticle in Nature on how a group of Jumonji proteins regulate the growth of cancer cells and are involved in the development of specific cancer types. BRIC’s ...

Scientists reveal structure of gateways to gene control

... The research reveals how the pieces of DNA that regulate genes at the transcription-promoter sites are pack...ugh said. "We might even discover some sites that regulate genes that we didn't even know existed." ...

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