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Tag: "regenerating" at biology news

New component of the 'brakes' on nerve regeneration found

Among the principal obstacles to regenerating spinal cord and brain cells after injury is the "braking" machinery in neurons that prevents regeneration. While peripheral nerves have no such machinery and can readily regenerate, central nervous system (CNS) neurons have their brakes firmly in pla...

Microreactor efficiently regenerates cofactors for biocatalysis

... or more cofactors are required." By continuously regenerating the required cofactors, the microreactor enables the desired biocatalytic processes. Kenis and his colleagues describe their work in a paper that has been accepted for publication in the Journal of the American Chemical Society, and posted on its Web...

For first time, brain cells generated in a dish

...he cells to generate specific neurons. "As far as regenerating parts of the brain that have degenerated, such as in Parkinson's disease, Huntington's disease and others of that nature, the ability to regenerate the needed cell type and placing it in the correct spot would have major impact," said Dr. Eric Hollan...

Researchers find molecule that inhibits regrowth of spinal nerve cells

... major role in inhibiting spinal-cord neurons from regenerating after injury, researchers at UT Southwestern Medical Center have found. In cultured cells, the researchers found that a component of myelin ?a substance that normally insulates and stabilizes long nerve fibers in adult vertebrates ?chemically blocks ...

Tissue regeneration operates differently than expected

...s rather than by simply becoming components of the regenerating organ. (Genes & Development, August 2005). St...into muscle cells. By fusing with the cells of the regenerating tissue these cells rather seem to only simulate such a transdifferentiation mechanism. This has majo...

Bone marrow stem cells may heal hearts even years after heart attacks

...of cell transplantation that is most efficient for regenerating damaged myocardium." Roberto Bolli, M.D., F.A.C.C., from the University of Louisville in Louisville, Kentucky, who co-authored an editorial appearing in the journal, wrote that a "veritable revolution" is underway to overthrow the belief that heart ...

Regenerating worms help elucidate stem cell biology

...ers, zebrafish, and other organisms are capable of regenerating entirely new body parts. Although the human body does not face such demands, it is constantly replacing lost cells. For example, blood replenishes itself, wounds heal, and the lining of the gut sloughs off and is restored. Nowhere, however, is the pr...

New understanding of regeneration gained by Forsyth scientists

...d an imposition of the correct morphology upon the regenerating tissue. Understanding this process is crucial for both the basic biology of pattern formation, and for developing novel biomedical approaches. Planaria have powerful regeneration capability that makes them ideal for studying this process. When the w...

Scientists crack code for motor neuron wiring

...ce to believe this -- so all you need to do is get regenerating axons to grow past the site of the lesion. "Or, it could be that injury causes subtle alterations in the wiring of spinal circuits, and these alterations may constrain the capacity for full recovery of motor function. So, the more that is understood...

Findings advance use of adult stem cells for replacement bone

...tant, not just because they hold great promise for regenerating healthy bone but also because they may be applicable to other tissues," said researcher Antonios Mikos, the John W. Cox Professor of Bioengineering and Director of Rice's Center for Excellence in Tissue Engineering. "This is also a notable personal a...

Mutation in blood stem cells provides clues to cancer development

... "There are primal pathways that are important for regenerating cells and tissues, and those are the same pathways that cancers use, subverting normal processes and using them for the wrong purpose. The discovery of this mutation means we can look toward interrupting these pathways, systematically, without wipin...

Spinal cord bridge bypasses injury to restore mobility

... the lesion site. These scars act as a barrier to regenerating axons and result in loss of the ability to breathe or move arms or legs, depending upon the injury site. Silver said the medical community also assumed that the cut axon tips died when they hit the scar wall. In prior research in his lab by his gr...

New study reveals signaling pathways required for expansion of pancreas stem cells

...t the Sarvetnick lab used contains an abundance of regenerating stem cells from the ducts. "Importantly, we found that if we inject an antibody that inhibits BMP4 into these mice, this significantly reduced the number of proliferating duct cells. We also found that in these mice inhibition of BMP4 results in an i...

OHSU study says stem cell 'fusion' occurs in tumors

...ng the molecular mechanisms that may be at work in regenerating rapidly turning over damaged tissue, or may even be implicated in disease progression. "The intestinal lining is the protective barrier between your body and the outside environment. Therefore, it sees all of the offensive contaminants that you inge...

Fat stem cells being studied as option for breast reconstruction

...re studying the potential these cells may have for regenerating new breast tissue. In animal models, the researchers hope to prove that an injection of fat-derived stem cells that are seeded onto microscopic scaffold structures will enable the production of a durable, replacement soft tissue. The team, led by J...

How does a zebrafish grow a new tail?

...in, Wnt8, also increases cell proliferation in the regenerating fin. "We can actually increase the rate of regen...hat Wnt/Beta-catenin signaling is activated in the regenerating zebrafish tail and is required for the formation and subsequent proliferation of the progenitor cell...

New data from NIH lab confirms protocol to reverse type 1 diabetes in mice

...ears that there are multiple potential sources for regenerating islets. As a research community we should pursue all avenues. We're excited to see what will happen in humans." In the 2001 and 2003 studies, Faustman and colleagues treated end-stage nonobese diabetic (NOD) mice with Freund's complete adjuvant,...

Replacing insulin is top-ranked breakthrough foreseen for health in developing world

... need for costly insulin injections for diabetics, regenerating heart muscle after it fails, and improving resista... has produced a skin substitute (Apligraf), a bone regenerating therapy (Osteocel) and other medical breakthroughs. An eye institute in India (L.V. Prasad) has use...

Newts which regrow their hearts

...volved in repairing newt hearts. he process of regenerating lost extremities is different. Unlike in the process with the heart, newts develop a blastema in this case. Blastema cells have certain characteristics in common with stem cells, such as the development into different cell types. The cell biologists ...

Growth factor stimulates rapid extension of key motor neurons in brain

...ng the neuronal degeneration of diseases like ALS, regenerating cells for the treatment of spinal cord injury, and to the potential replacement of neurons using precursors or 'neural stem cells'," says Macklis, who is on the faculty at Harvard Medical School. ...

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