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Tag: "reduced" at biology news

Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer

...s involved in carcinogenesis. To evaluate whether reduced DNA repair capacity in the nucleotide excision pathway that fixes DNA alterations known as bulky DNA adducts is associated with breast cancer risk, Regina M. Santella, Ph.D., of the Columbia University Mailman School of Public Health in New York, and...

Topical treatment shown to inhibit HIV and herpes simplex virus infection

...CVL obtained after the application of PRO 2000 gel reduced both HIV and HSV infectivity by at least 1000-fold compared to CVL obtained at baseline. The effects were highly statistically significant (p "An inflammatory responses could potentially increase susceptibility to HIV and limit any protective effect...

Controversial drug shown to act on brain protein to cut alcohol use

...ut classic behavioralstudies showing that Ibogaine reduced alcohol consumption. They inducedthe rats to consu...significantly reduced."The discovery that Ibogaine reduced binge drinking after a period ofabstinence was an exciting finding for us because this is the type o...

Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer

...ia-like traits. While the Nature study catalogs a reduced genome (sometimes characteristic of an organism's transition to a parasitic lifestyle), Loftus says scientists found ample evidence of a variety of gene families characteristic of more complex organisms. For example, a family of membrane receptors ap...

Iron Deficiency Sparks Dramatic Changes In Gene Expression

...y of more than 80 different genes was dramatically reduced inresponse to iron deprivation. The function of many of these genes isunknown, meaning that side effects from iron deprivation may gounattributed to their root cause. Other genes affected by ironstarvation are known to be vital in generating energy, ...

Yale Scientists Find MicroRNA Regulates Ras Cancer Gene

...s, compared with their normal adjacent tissue, had reduced let-7 and increased Ras -- the brakes on Ras were removed in lung tumors. "The discovery of a new aspect of the regulation and targeting of a well-known gene involved with cancer progression will have profound implications as we continue to focus on...

Mouse brain tumors mimic those in human genetic disorder

...rolmice."The fact that cell growth is dramatically reduced after a few monthsin mice and after a few years in humans tells us there may be growthsignals that are produced early in life, which are critical for tumorformation and expansion," Gutmann explains.Optic pathway gliomas in humans are typically surrou...

Muscle-targeted gene therapy reverses rare muscular dystrophy in mice

...gene, mice exhibited high levels of the enzyme and reduced glycogen content in the injected muscle. The mice also had a reduced immune response to the new enzyme, compared to those in which gene expression was not limited to mus...

Plant hemoglobins: Oxygen handlers critical for nitrogen fixation

...le agriculture and contributes millions of tons of reduced nitrogen to crops and pastures each year. As reported this week, researchers led by Dr. Michael Udvardi at the Max Planck Institute of Molecular Plant Physiology have succeeded in eliminating the production of symbiotic hemoglobins in nodules of the...

First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers

...ation-linked protein called Rac appears to be much reduced in cancer cells affected by the analogues, and the researchers also noticed that malignant cells failed to grow tiny "antennas," called lamellipodia, another crucial step in the migration process. "Therefore, the migrastatin analogues must be workin...

Open microfluidic and nanofluidic systems

... should lead to increased throughput and, thus, to reduced cost of (bio)chemical analysis. In addition, such integrated labs-on-a-chip have many potential applications in biomedicine and bioengineering. In the context of biomedicine, for example, they could provide fast and detailed analysis of blood samples...

Papers of DNA Pioneer and Nobel Laureate Francis Crick Added to National Library of Medicine’s Profiles in Science Web Site

...ncluding human consciousness and free will, can be reduced to fundamental laws of physics and chemistry, and can thus be explained entirely in rational, scientific terms. After 1953, Crick devoted most of his effort to solving the genetic coding problem, the problem of how genes controlled the synthesis of ...

Introduced foxes transformed vegetation on Aleutian Islands from lush grasslands to tundra

...h foxes, while populations of crevice nesters were reduced but not eliminated. Ledge nesters such as murres and kittiwakes, which nest on steep cliff faces, were less affected by the foxes, he said. "Wherever the puffins and gulls have come back after the removal of the foxes, the vegetation has started to ...

Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems

...ent ?and the percent of tumors that were fatal was reduced from 57 percent to 31 percent. The same pattern occurred for kidney disease, which was found in 74 percent of the normal male animals at the time of their deaths. None of the growth-hormone deficient animals developed kidney disease. They found tha...

An entropy-based gene selection method for cancer classification using microarray data

... compact, that is, the redundancy between genes is reduced to a large extent. This implies that classifiers can be built with a smaller subset of genes. ...

UCSD discovery may help extend life of natural pesticide

...s found that there was either zero or dramatically reduced binding of glycolipids to Bt toxin. They concluded that the defective sugar structure of the glycolipid receptor in each of the mutants prevents Bt from binding. Other members of the research team, coauthors Stuart Haslam and Anne Dell, biologists a...

White blood cell waste disposal system plays critical regulatory role

...hat the amount of IL-23 produced by phagocytes was reduced when phagocytes actively ingested apoptotic neutrophils. Interestingly, mice with abnormal neutrophils that lacked the ability to migrate into body tissues where they would have encountered phagocytes exhibited elevated IL-23 and IL-17 levels. When t...

The Bacteria's guide to survival

... MAPKs. The researchers showed that blocking MAPKs reduced the activity of several of the genes that are usually enhanced by infection with the normal bacteria. Also, they found that cells infected with the bacteria tended to survive treatment with staurosporine, a chemical that normally induces apoptosis. ...

Affymetrix and the Karolinska Institutet Announce Translational Medicine Strategic Alliance

...in higher levels of revenue, higher gross margins, reduced operating expenses, uncertainties relating to technological approaches, manufacturing, product development, market acceptance, personnel retention, uncertainties related to cost and pricing of Affymetrix products, dependence on collaborative partners...

Implanted Devices Detect High-Risk Heart Failure Patients

... would have a narrow footprint that represents the reduced variance in heart rate response," Gilliam explained. "These footprints provide us with an unbiased ?distinct from the patient's perception ?look at how the patient is truly doing. It is an objective finding that you can look at and easily understand....

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