Sickle cell disease corrected in human models using stem cell-based gene therapy
... patients, researchers found that the newly formed red blood cells made normal hemoglobin and suppressed ...auses an abnormal type of hemoglobin to be made in red blood cells. The aggregation of hemoglobin S inside red cells interferes with the body's blood cells...Seaweed yields new compounds with pharmaceutical potential
...ures with pharmaceutical potential in a species of red seaweed that lives in the shallow coral reef along... The source of these new molecular structures is a red seaweed (Callophycus serratus) collected from four Fijian sites. Among the sites, researchers found ...Multiple genes permit closely related fish species to mix and match their color vision
... types have maximum sensitivities ranging from the red end of the spectrum right through to the ultraviolet--light outside the range of human sensitivity. The researchers showed that in order to tune its color vision, each cichlid species primarily expresses three of the seven cone pigment genes encoded ...Brain activity related to processing faces is similar in people with, without autism
...genated hemoglobin, the iron-containing pigment in red blood cells. Researchers then can quantify these signals to generate maps of various brain functions. "The brain regions 'specialized' for face processing, the fusiform gyrus, activated almost identically in our autistic study participants and the...Scientists map one of biology's critical light-sensing structures
...hem to switch between two stable states that sense red and far-red light. The light is actually detected by a specialized pigment that sits within a pocket on the protein. Red and far-red light, says Forest, have the effect of reversibly changing the structure of the pigment in the pocket, which then fli...Compound from marine bacteria shows potential as multiple myeloma therapy
...ow that causes a plunge in the production of vital red and white blood cells. Although relatively rare, it is the second most common type of blood cancer and accounts for 11,000 deaths annually in the United States. Bortezomib, approved by the Food and Drug Administration in 2003 for relapsed myeloma pat...Researchers show key protein necessary for normal development of red blood cells
... that the KLF2 protein is crucial for making young red blood cells. The findings may point researchers ...enes and the maturation and stability of embryonic red blood cells in a mouse model. Researchers observed that KLF2 is responsible for controlling and "tur......gh linear motifs. "One challenge was to eliminate red herrings, which crop up everywhere when you look for very small patterns," Russell says. "The fact that nine of these motifs were already known was a sign we were on the right trail; we then did follow-up experiments in collaboration with Luis Serran...Researchers develop new method to help find deadly malaria parasite's Achilles heel
...proteins expressed in the phase that infects human red blood cells, an infection that leads to fever, sha..."Plasmodium presents many of these proteins to the red blood cell during infection and prior to replication," he said. "What really jumps out of our paper ...Targeted drug delivery achieved with nanoparticle-aptamer bioconjugates
...antly men over 50 years of age) and a diet high in red meat and dairy products.3 Once the cancer has been diagnosed it is graded and staged to assess the aggressiveness of the tumour and how far it has spread, and for evaluating the type of treatment required. Treatment can involve surgery, radiotherapy...Researchers use 'trickery' to create immune response against melanoma
...antly men over 50 years of age) and a diet high in red meat and dairy products.3 Once the cancer has been diagnosed it is graded and staged to assess the aggressiveness of the tumour and how far it has spread, and for evaluating the type of treatment required. Treatment can involve surgery, radiotherapy...Predators keep the world green, ecologists find
...is almost no leaf litter, and the ground is bright red from the subsoil brought to the surface by leaf-cutter ants. "Dead twigs, branches and vine stems from canopy dieback litter the ground, and in places lie in heaps. But in striking contrast with this scenario of destruction, the medium islands prese...Computers to save unique type of American red squirrel
... to North America to help prevent a unique type of red squirrel dying out in as little as 30 years time. ...ise developed while working with the threatened UK red squirrel - a completely different species to the Mount Graham variety despite the similar names - in...Horseshoe crab decline threatens shorebird species
Each year, the red knot, a medium-sized shorebird, makes a 20,000-mil...of any bird. And each year from April to June, the red knot stops over in the Delaware Bay to feed on horseshoe crab eggs resulting from the largest spawni...Marine mammals are on the frontline of failing ocean health
... for both manatees and humans. "Recent, frequent red tides off the west coast of Florida correlated wit...lleagues' work on manatee die-offs associated with red tides shows that inhalation of the toxin is also a primary route of exposure. Recent lab work also ...Invasive species harms native hardwoods by killing soil fungus
...ic mustard invasion. Three species -- sugar maple, red maple, and white ash -- had significantly less AMF root colonization and grew only about one-tenth as fast in the infested soil. Seedlings grown in sterilized, AMF-free soil taken from invaded and pest-free locations showed similar reductions, sugges...Malaria parasites develop in lymph nodes
... parasites burst out of the liver cells and infect red blood cells, beginning the onset of malaria. Al...rd said. Only fully developed parasites can infect red blood cells and cause malaria, so the lymph-node parasites probably don't contribute to the appearan...Powerful technique for multiplying adult stem cells may aid therapies
...ing of some of these cells develop into all of the red and white blood cells, while others form the immune system. Using fetal tissue from mice as the source of these cells, Zhang discovered a population of cells that were not stem cells, yet appeared to interact with stem cells, preserving and allowing ...The world's deepest dinosaur finding - 2256 metres below the seabed
...a pattern of fossil alluvial sand between banks of red shale. ......rotein to which it is attached. The green turns to red when the tags are zapped with an intense pulse of ...ness is further enhanced by the fact that it stays red for long-term protein tracking, Sergey Lukyanov explained. Dendra is the latest addition to the gro...