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Tag: "recurrence" at biology news

Blood test may help signal tumor's remission, return in throat cancer patients

...of a blood test that enables doctors to detect the recurrence of throat cancer early on, when there is still time to pursue a second line of treatment, such as surgery or drug therapy. “Cancers of the head and neck are insidious because surgical removal of the tumor can severely impair a person’s ability to ta...

Cancer stem cells similar to normal stem cells can thwart anti-cancer agents

...lls, which ultimately become the source of disease recurrence and eventual metastasis. Now, research by scientists at the University of Pittsburgh School of Medicine suggests that for chemotherapy to be truly effective in treating lung cancers, for example, it must be able to target a small subset of cancer ste...

How 'memory' T cells curb the spread of viruses throughout the body

...iruses, the body becomes “immune” (protected) from recurrence of the same disease. This is why before vaccines ... as “memory lymphocytes” and protect the body from recurrence of the disease. Similarly, vaccines induce the production of memory lymphocytes, but without causin...

Gene thought to assist chemo may help cancer thrive

...cer cells damaged by chemotherapy leading to tumor recurrence and explaining the higher mortality rate of patients whose tumors had a functioning p53. If we are correct, inhibiting p53 in tumors being treated with chemotherapy may substantially improve patients' long-term survival." McDonald and colleagues a...

Scientists identify pancreatic cancer stem cells

...er tumors shrink and may be responsible for cancer recurrence and metastasis. This study confirms at least one of those concepts, the researchers said. "Our study demonstrates that the very small subset of cells in a human pancreatic tumor that cause the cancer to grow and propagate have stem cell-like featu...

First-degree fetal heart block may be reversible

...ven with further intervention. "Given the high recurrence rate we confirmed in this study, close monitoring and the earliest possible marker is necessary," said Copel, who plans trials of other possible treatments. "Advanced block and permanent heart damage can occur within one week of a normal echocardiogr...

New cell type identified in cancer development

...ne the role of cancer stem cells in the growth and recurrence of the disease as well as offer new options for cancer prevention, detection and treatment. Current cancer stem cell theory holds that tumors are comprised of a variety of cell types. Among them is a small subset of rather primitive cells that, lik...

Cancer vaccines -- Taking a jab at cancer by stimulating the immune system

...ients. Four of the subjects have shown no signs of recurrence in the three years since the study began. "The trial was a look at the toxicity and feasibility of using a dendritic cell-based vaccine against pancreatic cancer," said Andrew Lepisto, Ph.D, post-doctoral researcher in the University of Pittsbu...

Tumor cells evade death through autophagy

...tosis and tumor regression was increased and tumor recurrence was substantially delayed. This study has clinical implications as it indicates that adjunct treatment with inhibitors of autophagy might increase the efficacy of apoptosis-inducing chemotherapeutics in human patients with cancer. ...

Leukemic cells find safe haven in bone marrow

..., a co-author of the paper. "That would reduce the recurrence rate of ALL and continue our successful efforts to increase the survival rate of ALL." Previous research at St. Jude and elsewhere had shown that direct contact with bone marrow mesenchymal cells is essential for the long-term survival and multip...

Adding radiation decreases breast cancer recurrence

...reast conserving surgery for breast cancer reduces recurrence and prevents development of additional breast tumo... conserving surgery, the risk of local or regional recurrence increased up to 3.5 times if they did not receive radiation after their surgery. Great strides hav...

Mechanical 'artificial hearts' can remove need for heart transplant by returning heart to normal

... 11 recovered. Of these, 88 percent were free from recurrence of heart disease five years later. Their quality of life was measured as being at nearly normal. Dr Emma Birks, from the Heart Science Centre at Imperial and the Royal Brompton and Harefield NHS Trust, and lead author of the study, said: "Donor he...

Gene signature assesses breast cancer outcomes

...t cancer can accurately assess a patient's risk of recurrence or death, according to an article in the September...e followed for 13.6 years and assessed for disease recurrence and death. The authors found that the 70-gene signature was a more accurate predictor of disease o...

Newly identified biomarker detects and regulates spread of brain tumors

...r ability to spread in the brain, a major cause of recurrence of malignant astrocytoma. Secreted by the tumors t...attractin modulates the migration and possibly the recurrence of these tumors makes it a promising target for future therapeutic intervention, says Dr. Van Meir. ...

Novel vaccine shows promise against early-stage breast cancer

...ave been known to predict the severity of disease, recurrence and overall survival. Developing novel therapies that target these specific genetic variances may be extremely beneficial in preventing breast cancer for many women. In this study, researchers investigated a potential vaccine that targets HER-2/...

Experimental vaccine protects mice against deadly 1918 flu virus

...searchers say, to understanding and preventing the recurrence of the H1N1 influenza virus that caused the 1918 pandemic and to protecting against virulent flu strains in the future, including the H5N1 avian flu virus. Details of the research are available online this week in Proceedings of the National Academy ...

Cigarette smoking impedes tendon-to-bone healing

... studies have reported short- to intermediate-term recurrence rates from 30 percent to 90 percent, depending on the size of the tear, chronic nature of the injury and the age of the patient, among other factors. "Especially during the first six weeks after surgery, tissue may be vulnerable to re-injury," say...

Restoring tamoxifen sensitivity in resistant breast cancer cells

... tamoxifen treatment initially reduced the rate of recurrence by nearly 50 percent. Over time, however, patients develop resistance to the drug and tamoxifen loses its effectiveness as a cancer treatment. "Tamoxifen has been extremely important in the management of breast cancer," said NCI Director John E. Ni...

Recurrence of a flu pandemic similar to infamous 1918 flu could kill 62 million

...amous 1918-1920 pandemic--and the possibility of a recurrence on that scale--that causes the most trepidation. Strangely, researchers still don't know exactly how many people died from this particular strain of the flu virus in that pandemic, and they know even less about how mortality rates varied in diffe...

Gene therapy study takes aim at prostate cancer

... prostate tumor will prove effective in preventing recurrence of the disease. The first phase of the study is designed to test the safety of the treatment and determine the proper dosage of gene, said Dr. Dov Kadmon, professor of urology at BCM. It will be carried out in the department of urology at BCM as we...

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