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Tag: "recruitment" at biology news

Mouse brain tumors mimic those in human genetic disorder

...to tumor formation."In our judgment, the fact that recruitment of new blood vessels andinfiltration of immune system cells occurs before actual tumorformation suggests that these events are important for the developmentof tumors," Gutmann says. "These findings raise the possibility thattargeted therapies for NF1...

NIAID Initiates Trial of Experimental Avian Flu Vaccine

Fast-track recruitment has begun for a trial to investigate the safety of a vaccine against H5N1 avian influenza, the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), announced today. Sites in Rochester, NY, B...

UCLA launches $20 million stem cell institute to investigate HIV, cancer and neurological disorders

... passage of Proposition 71. The money will pay for recruitment for a dozen new faculty positions, salaries and expansion of highly sophisticated laboratory space, infrastructure, and supplies. Dr. Owen Witte, a renowned scientist whose laboratory research laid the groundwork for development of the targeted leuk...

B cells are required for development of epithelial cancer associated with chronic inflammation

...ggest that drugs targeted against B lymphocytes or recruitment of innate immune cells toward premalignant tissue ...ting B cell activation or blocking B cell-mediated recruitment of innate immune cells may be effective in preventing premalignant progression." ### The researche...

Tamoxifen-like drug suggests new ways to selectively block estrogen

...mation." Since "the primary regulator of cofactor recruitment is receptor conformation," added study co-author Donald McDonnell of Duke, findings such as this should lead to the emergence of "a new wave of estrogen receptor modulators with improved specificity. We are moving, he said, "very close to the day whe...

Researchers find Amchitka seafood safe for now

...ectly into the academic literature. * Required recruitment and coordination of unusually diverse scientific talent. Fourteen senior scientists from 6 major universities were involved in the work. * Field work in a very remote and taxing environment: Six senior scientists leading 18 additional researchers...

UK sperm donor crisis

...e of sub-optimal semen quality). At the end of the recruitment and testing process fewer than four in a hundred (3.63%) were accepted as suitable donors. Overall, there was a downward trend in the annual number of applicants from around 175 in 1994 to about 25 in 2003, with the sharpest fall occurring from 200...

How Rickettsial pathogens break into cells

...i specifically binds to Ku70, and that binding and recruitment of Ku70 at the surface of the host cell are important events in R. conorii's invasion of mammalian cells. In addition, since Ku70 has previously been shown to control cell death, the new findings suggest that Rickettsia, which--like several other int...

Chlamydia parasite lives off our fat

...ays Kumar. "Alternatively, it is possible that the recruitment of lipid droplets constitutes an example of 'organelle mimicry' where Chlamydia escapes recognition by the host by cloaking itself in these fat-rich structures." Understanding host lipid transport by Chlamydiae may have further implication for chro...

Source of crucial immune cell in the skin discovered

...e able to enhance tumor vaccines by increasing the recruitment of Langerhans cell precursors to the skin," said Dr. Merad. Additionally, the researchers point out that the new findings hold promise for potential therapeutic for patients with a Langerhans histocytosis, a rare disease effecting approximately 200,...

Marijuana-like compounds suppress the immune response

...l migration to study the involvement of CB2 in the recruitment white blood cells. They found that treating the blood cells with compounds that bind to CB2 suppresses the migration of the cells. When they examined the cells, they discovered that they had lost their ability to develop a front/rear polarity, whic...

GlycoFi announces the first production of antibodies with human glycosylation in yeast

...on the surface of cancer cells, followed by 2) the recruitment of immune system "effector" cells that bind the constant domain of the antibody and destroy the cancer cell to which the antibody is bound. Research has shown that this process, known as antibody dependent cell cytotoxicity (ADCC), is sensitive to th...

Honeybee decision-making ability rivals any department committee

... have discovered, but because the bees grade their recruitment signals in relation to site quality, the scouts build up most rapidly at the best site. As soon as 15 or more bees are at any one site, the researchers found, the scouts signal to the waiting bees in the swarm that it's time to warm up their flight...

Multi-million pound UK Biobank underway

...d records. The objective of the initial phase of recruitment is to make sure all of the planned procedures go smoothly before the study gets underway nationwide later in the year, when around eight to 10 assessment centres will be running at any one time around the UK. Sir Alan Langlands, the Chair of UK Biob...

Nobelist discovers antidepressant protein in mouse brain

...nd according to Greengard, p11 plays a role in the recruitment of receptors to the cell surface where they are more functional. This finding led the researchers to suspect that p11 levels might be directly involved in the development of depression, anxiety and similar psychiatric illnesses thought to involve f...

APS lecturer shows rare video of 'teacher-student' immune cell interactions in live animal

...rian explained. "My lab is interested in leukocyte recruitment and trafficking, particularly in the lymph nodes." The lymph nodes are the school, the dendritic cells the teachers and the T cells the students, von Andrian explained. Dendritic cells find foreign invaders, rip them apart and bring the pieces (anti...

Tumor wizardry wards off attacks from the immune system

... at several potential ways to interfere with tumor recruitment of T-reg cells," Linehan says. "We'd like to see these findings advance cancer immunotherapy. We want to find a way to actively suppress T-reg cells and at the same time actively evoke an immune response to tumor-specific antigens." In collaboratio...

Solved: The mystery of flesh-eating bacteria's relentless attack

...am began to search for the factor that blocked the recruitment of white blood cells during M14 infection. They focused on the gene for a Streptococcus peptide called SilCR, after finding that the gene product was turned off in the M14 strain. "This gene is supposed to produce a peptide that acts as a signalin...

Cougar predation key to ecosystem health

... hypothesize that the long-term lack of cottonwood recruitment associated with stream-side areas in Zion Canyon indicates the effects of low cougar and high deer densities over many decades. "It's a great research setting and a great opportunity to assess the potential importance of a key predator," he said. "...

'Allergy cells' can aggravate cancer and psoriasis

...e mast cells to release proteins that regulate the recruitment of inflammatory cells. Since it is already known that levels of CD30 are higher in people with psoriasis or atopical eczema and with Hodgkins lymphoma, the results can explain how the mast cells are activated and how they aggravate inflammation in th...

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