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Tag: "recruit" at biology news

Novel Enzyme Shows Potential As An Anti-HIV Target

...ing polymerase complex. Since acetylated Tat can’t recruit CyclinT1 and CDK-9, the authors explain, a new round of transcription requires that new, unacetylated Tats are produced or existing Tats are deacetylated. Thus, efficient viral replication depends on adequate Tat supplies. And since HIV gene expressi...

Controlling protein diversity

... are activated to seek out target genes. They then recruit the coactivators ?in this case CAPERá and CAPERâ. These coactivators not only cause the gene to begin the process that results in protein production, they also determine what kind of RNA (a kind of genetic template for the protein) is made as well as...

Nanoparticles offer new hope for detection and treatment

...ork for most solid tumors, because all tumors must recruit new blood vessels to obtain nutrients as they grow. Nevertheless, melanoma has unique traits that make it especially interesting as a target for nanoparticle therapy. Melanoma has a horizontal phase, when it spreads across the skin surface, and a ve...

A little stress gives beneficial oomph! to immune system

...ress hormones work with these kinds of proteins to recruit immune cells could help us develop therapeutic interventions to regulate how a person's immune system responds to different challenges." ...

'EuroVacc 02' HIV Vaccine Trial Begins

...ow risk of acquiring HIV infection. The study will recruit 40 healthy volunteers: 20 at the Centre Hospitalier Universitaire Vaudois (CHUV) in Lausanne, and 20 at St Mary's Hospital, Imperial College London. All volunteers, male or female, should be between 18 and 55 yrs, HIV-negative and at low risk of infe...

B cells are required for development of epithelial cancer associated with chronic inflammation

...ytes in this model system resulted in a failure to recruit innate white blood cells to premalignant skin and an absence of chronic inflammation. As a consequence, parameters of early cancer development were attenuated, and cancer incidence was significantly reduced. The researchers went on to show that trans...

Bumblebees copy one another when contending with unfamiliar flowers

...blebees are highly social insects, but they do not recruit nestmates to feeding locations, and foragers have therefore been thought to rely mainly on individual experience when seeking out rewarding flowers. The role of other bees in these decisions has been considered only in the context of deterrence becau...

Improving the potential of cancer vaccines

...es," said Wang. "In fact, tumor cells can actively recruit and activate them to turn on their immune suppressive function." One way to stop this action is to simply wipe out the cells with chemoagents or a specific antibody. "But you may also deplete the good cells needed for fighting cancer," said Wang. ...

Unweaving amyloid fibers to solve prion puzzles

...ften composed of prions--proteins that misfold and recruit neighboring proteins to misfold as well, a process that Lindquist calls a "conformational cascade." When such a cascade occurs, the prions join and form amyloid fibers. (While not all amyloids are composed of prions, all known prions, in their transm...

Clinical trial to test stem cell approach for children with brain injury

...effects. Cox and Baumgartner have permission to recruit 10 head injury patients to the study between the ages of 5 and 14 who meet criteria set for enrollment. After initial treatment and evaluation, a pediatric surgeon will approach the injured child's parents to explain the trial and request permission...

PET imaging reveals the immune system at work

...e a critical part of the immune system, helping to recruit key disease-fighting immune cells. "This lets us see not only how but where" the body is responding to disease, Witte explained. "The immune system resides throughout the body, and it is not going to be responding the same everywhere." Moreover, a ...

Jefferson biologist coaxing human embryonic stem cells to make dopamine with simpler, faster method

...e a critical part of the immune system, helping to recruit key disease-fighting immune cells. "This lets us see not only how but where" the body is responding to disease, Witte explained. "The immune system resides throughout the body, and it is not going to be responding the same everywhere." Moreover, a ...

Discovering the first steps in transcription-coupled repair

...wn. It appears that either CSB or XPG is needed to recruit TFIIH to the stalled polymerase, and it's likely they do this more efficiently when working together. The new findings suggest that one of the major functions of TFIIH -- previously unsuspected -- is to clear the way for transcription-coupled repair ...

UK sperm donor crisis

...cruiting donors. "It is difficult and costly to recruit sperm donors. With the change in the anonymity rul...ssue of recruitment. "It is clear now that we can recruit only donors willing to be identified that we need to change our strategies to target older men in es...

Taking a bite out of a fellow worker helps wasps recruit new foragers

...n a colony of the social wasp Polybia occidentalis recruit new foragers to gather water, food and building ma...y food, are not coming in. So the colony needs to recruit new workers to make up for the loss," O'Donnell explained. On the final day observers watched each ...

Weizmann Institute suggests that immune cells help to maintain cognition and brain cell renewal

...NS components do not attack the brain but instead, recruit the help of the brain's own resident immune cells to safely fight off any outflow of toxic substances from damaged nerve tissues. In the present study, the scientists showed that the same immune cells may also be key players in the body's maintenan...

Multi-million pound UK Biobank underway

...utionary research undertaking that will eventually recruit half a million volunteers aged 40 to 69. The project ?a UK world first ?will gather, store and protect a vast bank of medical data and material that will allow researchers to study in depth, in decades to come, how the complex interplay of genes, li...

Thinner and younger

... Currently, Holloszy and Fontana are beginning to recruit volunteers for Phase II of the CALERIE study. ...

Chocolate, wine, spicy foods may be OK for heartburn, Stanford study finds

... heartburn. "It probably wouldn't be that hard to recruit volunteers for a study of chocolate," Gerson noted. "People like to eat chocolate." ...

How can identical twins be genetically different?

...proteins that degrade tissue, uses angiogenesis to recruit new blood vessels to supply it with nutrients. The angiogenic factor Cyr61 could be involved with this process. "This paper describes only a glimpse of what this approach might reveal. There are many other categories of genes where expression varie...

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