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Tag: "recombinant" at biology news

Minor mutations in avian flu virus increase chances of human infection

...n optimize its specificity to the new host." "Our recombinant approach to the structural analysis of the Viet04 virus showed that when we inserted HA mutations that had already been shown to shift receptor preference in H3 HAs to the human respiratory tract, the mutations increased receptor preference of the Vi...

New influenza vaccine takes weeks to mass produce

...are then infected with the baculovirus and produce recombinant hemagglutinin (rHA). Phase II clinical trials sho...9 or H2 influenza viruses. The preparation of the recombinant baculoviruses for the production of these antigens and the successful purifications gives us a great...

GlycoFi announces the first production of antibodies with human glycosylation in yeast

...ale. The company believes that as the scale-up and recombinant production of proteins in yeast is a well established technology, more easily achieved than mammalian cell culture, it should be possible to produce specific designer glycoproteins at large scale using the company's engineered yeasts. GlycoFi has alr...

Human albumin from tobacco plants

...astidial transformation, in order to produce, in a recombinant form, human albumin from tobacco plants. According to her PhD thesis, plastidial transformation is an economically viable alternative, as it enables increasing the levels of HSA by between 10 and a 100 times, compared to levels obtained by nuclear tr...

Human trial proves ricin vaccine safe, induces neutralizing antibodies; further tests planned

...have completed the first human clinical trial of a recombinant vaccine for the deadly toxin ricin ?a potential bi...vaccine, called RiVax, over the study period. As a recombinant vaccine, RiVax is a form of ricin that consists of a genetically modified subunit of the toxin, rath...

Researchers offer proof-of-concept for Altered Nuclear Transfer

...ually found in bacteria, and they are a staple for recombinant DNA techniques.) The stem cells resulting from this procedure proved to be just as robust and versatile as stem cells procured in the more traditional fashion. "The success of this procedure in no way precludes the need to pursue all forms of human...

Hepatitis C complicated by morphine withdrawal

...s well as host cells, and the only one approved in recombinant form for treating HCV infection). To further these results, his lab has used a cell model system to determine the consequences of morphine withdrawal, which is a common recurring event in opioid users. Chuan-Qing Wang and colleagues examined the ...

Promising therapies for haemophilia & heart disease

...e with haemophilia rely on intravenous infusion of recombinant Factor VIII clotting protein. Professor Denisa Wagner and her Harvard colleagues have made ground-breaking discoveries that provide hope of an alternative treatment option for haemophilia sufferers. Presenting this research, at the XXth Congress of...

Engineered molecule amplifies body's immune response

...t the development of cancer. Because of this role, recombinant interferon is often used for the treatment of cert...y performing gene transfer experiments, using both recombinant viruses and transgenic mice, to establish the benefits of hyper-responsive Stat1 in vivo for treatin...

Gene therapy advance treats hemophilia in mouse models

...s for hemophilia involves intravenously delivering recombinant (genetically engineered) human factor VIII protein to prevent bleeding episodes. However, the weekly to bi-weekly preventive treatments are extremely expensive, costing up to $500,000 per year. In addition, over time some patients may develop antibod...

Tetanus toxin found to have therapeutic properties

...ers have also been able to show that toxin and its recombinant fragment, carboxy terminal, the harmless fragment, strengthens the neural cells and protects them from external aggressions. This means it has a neuroprotective effect that prevents the death of the neurons when they are faced with aggressive situati...

Fragment of yellow fever virus may hold key to safer vaccine

...acturers design a more consistent vaccine based on recombinant genetic technology, without the potential side effects from variations of the weakened virus strain now grown in fertilized chicken eggs. ...

Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs

...ocess that is detailed in the PNAS paper. "Through recombinant DNA technology, we combined the genetic codes for both human transferrin and G-CSF to create a new recombinant DNA, which, when expressed in a cell, will produce a protein with half transferrin and half G-CSF," ...

Protein prevents detrimental immune effects of bacterial sepsis

...in 1 knockout mice were given small doses of human recombinant annexin 1 in the first 24 hours following LPS treatment, survival increased to 60%. These results, obtained in the lab of Dr. Mauro Perretti, highlight the delicate balance between the "pro-inflammatory/detrimental vs. anti-inflammatory/protective p...

HIV vaccine trial breaks ground for future research

...ticipants. The vaccine, produced by VaxGen, was a recombinant construct of the HIV envelope glycoprotein, similar to the type of vaccine used to develop a vaccine for hepatitis B. The vaccine was tested in a double-blind, randomized study of healthy participants who did not use intravenous drugs. The volunteers...

The death of a very special chimpanzee

...n can nowalso be produced in large quantities as a recombinant protein inbacteria, making it highly available for medicinal or otherapplications.Called SP-1, the protein has a nanometric, "bagel-shaped," circularform and is extremely stable. It has been found to be capable ofsurviving contact with enzymes that b...

New protein discovered by Hebrew University researchers

...n can nowalso be produced in large quantities as a recombinant protein inbacteria, making it highly available for medicinal or otherapplications.Called SP-1, the protein has a nanometric, "bagel-shaped," circularform and is extremely stable. It has been found to be capable ofsurviving contact with enzymes that b...

Live Recombinant Adenovirus Vaccine Technique Explored

... their process for constructing a replicating live recombinant adenovirus could lead to more economical vaccines ...of live adenovirus vaccine with the versatility of recombinant adenovirus virus vaccines that are being developed.?/p> Specifically, Dr. Ketner and his colleag...

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