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Tag: "recognizes" at biology news

Scripps research scientists solve structure of a critical innate immune system protein

...ans have at least 10 different TLRs, each of which recognizes a specific subset of antigens. For instance, TLR4 recognizes lipopolysaccharide, a chemical component of the cell walls of certain bacteria like Neisseria mening...

Scientists take aim at virulent bacteria by decoding machinery of key control enzyme

...ds to the DNA and moves along the base pairs as it recognizes and methylates the A nucleotides," says Dr. Cheng. "Using this information we can potentially design a drug to inhibit this particular enzyme's chemical reaction or its DNA binding process. This kind of rationally designed drug could be an alternativ...

Scientists discover global pattern of big fish diversity in open oceans

...sing management decisions in a larger context that recognizes our cumulative and rapid impact on the ocean system. The good news, say these scientists, is that there is hope for the future. The key pieces of the global biodiversity puzzle are still out there, including the physical structures upon which the bi...

Researchers pioneer new gene therapy technique using natural repair process

...ecombination by introducing a man-made enzyme that recognizes and binds DNA at specific points into human immune cells harboring the mutant IL-2R gene. Once bound to the mutant gene, the enzyme creates a break in the DNA sequence, initiating the recombination process. In SCID, as well as many other diseases, b...

A probe, not an echo

...ue. A sophisticated coding/decoding signal scheme recognizes a small "sweet spot" of the signal coming from the opposite transducer, and only that transducer, and ignores all other pulses transmitted by neighboring transducers. The transducer is able to distinguish the right signal from the right transducer b...

Chemical Engineer Kao Explores Antibiotic Synthesis With DNA Chips

...he 2004 Jay Bailey Young Investigator Award, which recognizes the best paper in the journal Metabolic Engineering. Funded by the National Science Foundation and the National Institutes of Health, Kao's research uses a "reverse engineering" strategy to learn from and exploit drug-company mutants--in this case t...

Software Tool for Converting Scientific Text into a Database of Functional Relationships

...een proteins, cell processes, and small molecules, recognizes types of regulatory mechanisms involved and the effects of regulation, and can be customized to extract other types of information. "The majority of pharmaceutical and biotechnology companies recognize the need for an in-house information extraction...

A New Species of Monkey is Discovered in Tanzania: The First in Africa for More Than 20 Years

...taxonomic name of the species, Lophocebus kipunji, recognizes the monkey’s local Kinyakyusa name (pronounced kip-oon-jee) used by a few hunters around Mt. Rungwe. The highland mangabey is extremely rare and critically endangered, with an estimated total population of between 500 and 1,000 animals. Also noted b...

Revolutionary nanotechnology illuminates brain cells at work

...if they move away from one another when the sensor recognizes glutamate. Thus, there is more cyan and less yellow light than in the absence of glutamate. The sensors are encoded by genes and genetic ZIP codes can be used to target the sensors to any location in the cell and to its surface. "We used a protein c...

Affymetrix Licenses Microfluidics Technology From Caliper Life Sciences

...at a leading life sciences company like Affymetrix recognizes the vast potential of LabChip technologies," said Kevin Hrusovsky, President and CEO at Caliper. "Affymetrix is moving beyond basic research applications and is pioneering areas such as pharmacogenomics and personalized medicine. Incorporating our te...

NIH Calls on Scientists to Speed Public Release of Research Publications

...ate release is not possible," Zerhouni added. "NIH recognizes the importance of preserving quality peer review and the viability of a diversity of publishing models. Nevertheless, we expect that only in limited cases will authors deem it necessary to select the longest delay period." The NIH policy will achiev...

Circles Of DNA Might Help Predict Success Of Stem Cell Transplantation

...ceptors on their surface. The target that a T cell recognizes and attacks depends on the makeup of its receptor, which is constructed of protein building blocks. Each protein building block is coded by a specific gene. sjTRECs form during a "mix-and-match" rearrangement of these genes into any one of countless ...

New Technique for Tracking Gene Regulators

...ndthen cut the DNA with a “restriction?enzyme that recognizes aparticular nucleotide base sequence, CATG. Further manipulation of thecut ends allows them to isolate 20-base-long-fragments, or “tags,?ineach direction from these cut sites. This gives the scientists a largenumber of very short DNA “tag?sequences, ...

Research advances quest for HIV-1 vaccine

...ainst HIV-1 that is currently known. This antibody recognizes a protein called gp41 that is found on the surface of the virus. The gp41 protein is thought to play a key role in mediating entry of HIV-1 into human cells. A research group led by Drs. Dennis R. Burton and Ian A. Wilson from The Scripps Research I...

Timing is everything: First step in protein building revealed

... found that when yeast'sprotein-building machinery recognizes the starting line for a gene'sinstructions, it first alters its structure and then releases a factorknown as eIF1, a step necessary to let it continue reading the assemblyinstructions. Even though yeast are the most primitive relatives ofhumans, the ...

New binding target for oncogenic viral protein

...ins to mark them for destruction by the cell. Fbw7 recognizes a destruction signal on certain proteins that need to be degraded and brings them in close proximity to the enzymes that attach ubiquitin. The proteins recognized by Fbw7 play key roles in cell division, cell growth, differentiation, and cell death. ...

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