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Tag: "recognizes" at biology news

Breakthrough developments in rheumatoid arthritis reported

...stem antibody associated with rheumatoid arthritis recognizes citrulline, which seems to be a key player in the condition. Indeed, the HLA associations with RA have now been shown by Dr. Gregersen and others to directly regulate the immune response to proteins containing citrulline. Citrulline is formed when a...

Newly discovered antibody may be body's natural defense against Alzheimer's

...und in human blood suggests that the immune system recognizes these aggregates to be a particularly noxious threat. "This could be part of an innate defense mechanism against Alzheimer's and other age-related neurodegenerative disorders," comments Dr. Marc Weksler, The Irving Wright Sherwood Professor of Ge...

Australian wins prestigious prize in biodiversity informatics

...versity informatics. The yearly award of €30,000 recognizes a researcher who is combining biosystematics and biodiversity informatics research in an exciting and novel way. Speaking about the Prize when he was notified, Flemons said "I am honoured by the award. GBIF is making a significant contribution to bi...

Salk scientists hammer out a pathway that promotes muscle cell survival in mice

...led salt-inducible kinase-1, or SIK1, specifically recognizes and phosphorylates HDAC. Then, to explore the possibility that SIK1 is the enzyme controlling the HDAC brake in muscle cells, the researchers reduced SIK1 activity in muscle cells grown in the lab using a technique that silences gene expression. ...

Technique monitors thousands of molecules simultaneously

...treating the bound receptors with an antibody that recognizes the receptor and is tagged to a fluorescent label. The washing step risks removing a bound receptor if it does not bind the molecular key strongly enough. But, with an electrochemically addressable computer chip, provided in great abundance by one of...

Scientists learn the origin of rogue B cells

...f immunoglobulin genes results in an antibody that recognizes a component of one's own body. While the body has a built-in mechanism to correct these errant cells, the NIAMS researchers discovered this doesn't always work the way it was intended. "What happens is that, if the body ever produces a cell with a se...

Microbes start immune response by sneaking inside cells

...new details to an emerging picture of how the body recognizes invading bacteria and responds. The work of the U-M team and researchers elsewhere ?now taking place in laboratory animal studies ?offers a different way of thinking about how best to design future human vaccines, as well as drugs that could more pre...

Antibody therapy prevents type 1 diabetes in mice

...type of protein produced by the immune system that recognizes and helps fight infections and other foreign substances in the body -- directed against a receptor known as CD137 on the surface of a type of immune cell called T-cells. Treating NOD mice with the anti-CD137 antibodies significantly suppressed the de...

Vasectomy may put men at risk for type of dementia

... and semen mixes into the blood. The immune system recognizes the sperm as invading foreign agents and produces anti-sperm antibodies in 60 to 70 percent of men. Weintraub said these antibodies might cross the blood-brain-barrier and cause damage resulting in dementia. "There are other neurological models of...

Yale biologists 'trick' viruses into extinction

... against human viruses like HIV. He notes that HIV recognizes the T-cells it infects by CD4 molecules on the cell surface, but it then requires functions of the cell nucleus to reproduce. Current anti-HIV therapies are designed to maintain high T-cell counts in the human body, so that the immune system can prop...

What recognizes what in plant disease resistance?

...tance (R) gene encodes a protein that specifically recognizes and protects against one pathogen or strain of a pathogen carrying a corresponding Avirulence (Avr) gene. In tobacco and its relatives, the N resistance protein confers resistance to infection by the Tobacco mosaic virus (TMV). The authors used N,...

Canada's new government invests $200M in the fight against the mountain pine beetle

...m economic well-being. The Government of Canada recognizes that the forest industry is an important contributor to the Canadian economy and that it has been facing considerable challenges. This investment is part of the $400 million provided in Budget 2006 to help the industry meet its challenges and ensure ...

Nanoparticles for delivery of prostate cancer treatment

...ule that Garen and Hu constructed, called an Icon, recognizes the receptor tissue factor (TF) found on cells lining the inner surface of blood vessels in tumors but not in normal tissues. The Icon binds to TF more strongly and specifically than a natural antibody. Because the Icon acts through the blood, it can...

Science researchers genetically transform immune cells into tumor fighters

...lls carry a receptor protein on their surface that recognizes specific molecules called antigens on tumor cells....lls contain genes that make a T cell receptor that recognizes breast or lung cancer cells. With this in mind, Rosenberg and colleagues created tumor fighters b...

Environmental toxins may cause body's defenses to worsen lung disease

...tify and destroy diseased cells. If the lymphocyte recognizes the tissue, Borchers explains, it simply continues its survey for problems. But if the cell receives a signal that the tissue is infected, it will automatically destroy it to protect the body from disease. "The immune system thinks it's eradicating ...

Gene-bender proteins may sway to DNA

...nsient opening of base-pairs, and that the protein recognizes and binds tightly to the bent DNA conformation." Conclusions by Ansari and her colleagues deviate slightly from the conventional dogma that it is the protein that bends the DNA. She said the results raise important questions about the role that th...

'Best of both worlds' -- Targeting a single gene could inhibit bone decay and stimulate bone growth

...m Prize for his work in osteoimmunology. The award recognizes scholars and researchers who make outstanding achievements by international standards while encouraging future activities of even higher levels and who also present exemplary models for the academic community. Choi, who is originally from Seoul, Sout...

HIV gets a makeover

...first was a protein called TRIM5 that, in monkeys, recognizes the outer shell or "capsid" of HIV-1 but not that of SIV. By swapping out the capsid region of the HIV-1 genome for that of the monkey virus, and then selectively growing the viruses that replicated most robustly, over several generations Hatziioanno...

Engineer ramps up protein production, develops versatile viral spheres

...he journal Biotechnology & Bioengineering, and recognizes the most outstanding paper of the year in that journal. Swartz, who holds the Leland T. Edwards Professorship in the School of Engineering at Stanford, will receive the award for a paper showing for the first time how glucose, the abundant sugar prod...

Molecular structure reveals how botulinum toxin attaches to nerve cells

...xin B (one of seven toxins the bacterium produces) recognizes receptors on the surface of human neurons. The structure reveals how these toxins work at the molecular level and provides a promising new target for designing drugs to block the action of botulinum neurotoxins. ...

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