Discovery of New Dopamine Action May Yield Alternative Psychiatric Drugs
...e protein switches on the surfaces of neurons that recognize neurotransmitters and translate their signals into a cellular response. Dopamine exerts its functions in the brain by binding to two broad classes of receptors -- one class that transmits signals fast and another that acts through signaling pathways ...Scientists use manufacturing methods to reconstruct mastodon
...dult female mastodon shown together." It will also recognize the American Mastodon as Michigan's state fossil, a distinction bestowed in 2002, after Washtenaw Community College professor David Thomas and students from Ann Arbor's Slauson Middle School petitioned the State Legislature. The expanded exhibit wil...U.N. mulls the protection of Earth's forests
...rine Karr Colque, recommend world governing bodies recognize the importance of forests to countries' long-term sustainable development, and urge states to integrate forest policy into their long-term development plans. This report was written with support from Indiana University and the U.S.D.A. Forest Service...Researchers test new therapy for advanced melanoma
...eins. These proteins signaled the immune system to recognize the melanoma tumors as abnormal and attack. Eighty percent of the mice were cured with this therapy -- their tumors disappeared and the treated animals remained disease free for the full length of the study (100 days), Dr. Heller said. Furthermore,...Purdue researchers use enzyme to clip 'DNA wires'
...res. "We weren't sure the enzyme would be able to recognize the DNA sequence covered with particles," Kinsella said. "We thought the particles might hinder the process." The researchers found, however, that the particles did not interfere with the process, possibly because the electrical charges are strong e...Remote control flies? Fly behavior controlled by laser light
...pped with molecular "receivers" that allow them to recognize an outside signal like a laser light pulse and translate that signal into the electrical signals characteristic of nerve-cell activity. To accomplish this, Miesenböck and Lima devised a triggered molecular lock and key system, where the "lock" was t...Fox Chase study shows that weakened T-cell receptor signals change T-cell lineage
...of humans to resist disease," said Wiest. "T cells recognize these invaders by means of a surface structure called the T-cell antigen receptor complex, or TCR." Two distinct lineages of T cells utilize distinct types of TCR complexes. One lineage employs pairs of TCR proteins termed alpha-beta while the other...Building a protein name dictionary from full text: a machine learning term extraction approach
...the literature. Results We present an approach to recognize named entities in full text. The approach collects high frequency terms in an article, and uses support vector machines (SVM) to identify biological entity names. It is also computationally efficient and robust to noise commonly found in full text ma...Touching Molecules With Your Bare Hands
.... Since a majority of epitopes that killer T cells recognize come from aborted translation events, it may be that evasive action is taken at the RNA transcript stage, before RNA is translated into protein. Evading killer T cells, the authors argue, is key to the survival of the gamma-herpesvirus. By figuring o...How A Latent Virus Eludes Immune Defenses
.... Since a majority of epitopes that killer T cells recognize come from aborted translation events, it may be that evasive action is taken at the RNA transcript stage, before RNA is translated into protein. Evading killer T cells, the authors argue, is key to the survival of the gamma-herpesvirus. By figuring o...Newly Discovered 'Branding' Process Helps Immune System Cells Pick Their Fights
... the chances that cells known as lymphocytes would recognize the trespassers and attack them. "Now that we know that some T cells need to see these types of modifications to identify an invader, we can see if incorporating such changes into the proteins is helpful for vaccination," says senior author Emil R. ...Software Tool for Converting Scientific Text into a Database of Functional Relationships
...rity of pharmaceutical and biotechnology companies recognize the need for an in-house information extraction technology that would help them to process literature, patent applications and internal text documents in order to create and automatically maintain internal functional relationship databases, amenable ...Distributed Basic Local Alignment Search Toolkit (W.ND-BLAST)
...ocessed medical devices. As hospitals increasingly recognize the risks to patient health, they are employing a variety of treatment technologies to attempt to eradicate microbes from incoming water. Dr. Cervia described the different types of systemic disinfection methods used and the advantages and disadvanta...New strategies to reduce hospital-aquired infections
...ocessed medical devices. As hospitals increasingly recognize the risks to patient health, they are employing a variety of treatment technologies to attempt to eradicate microbes from incoming water. Dr. Cervia described the different types of systemic disinfection methods used and the advantages and disadvanta...Gladstone investigators discover how resting T cells avoid HIV infection
...trating immune responses. They have the ability to recognize specific antigens -- foreign substances, such as toxins, bacteria or environmental factors -- through receptors on their surfaces. Roughly 95 percent of CD4 T cells in the blood stream exist in a resting, inactive state, awaiting the appearance of th...Biochemists report discovery of structure of major piece of telomerase; implications for cancer
...s of DNA and RNA, and how proteins and DNA and RNA recognize one another to switch genes on and off in cells. Her laboratory has worked on telomeres and telomerase for more than a decade. A member of UCLA's faculty since 1985, Feigon was the first UCLA scientist to use NMR to determine DNA and RNA structures.......ecause of the intransigence of those who failed to recognize that other sovereign States might want to permit strictly controlled applications of therapeutic cloning. The Declaration was a non-binding political statement, which would not affect Britain's position on the issue. China felt the prohibitions in t...MUHC scientists describe genetic resistance to rampant virus
... on the ability of our body's defense mechanism to recognize and destroy them. "Detecting these pathogens is no...the other gene allows our Natural Killers cells to recognize and terminate them. "This is a new concept in natural disease resistance," notes Dr. Vidal. "Our res...Novel gene-silencing nanoparticles shown to inhibit Ewing's sarcoma
... die as a result of their disease. Scientists now recognize that Ewing's sarcoma results when two chromosomes break and trade their genetic content in what's technically called a "translocation," activating the oncogene EWS-FLI1 which triggers the tumor growth characteristic for this cancer. In their experim...Genpathway and Baylor College of Medicine Identify New Genes in Breast Cancer
...mbination of receptors, and that each receptor can recognize multiple odorants. "So, the odorant receptor family is being used combinatorially," she said. "Just like letters of the alphabet are used in different combinations to form different words, the odorant receptors are used in different combinations to d...