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Tag: "receptor" at biology news

Scratch no more: Gene for itch sensation discovered

...rin-releasing peptide receptor), which codes for a receptor found in a very small population of spinal cord ne...GRPR and itching, offering the first evidence of a receptor specific for the itch sensation in the central nervous system. The findings are reported this week i...

Nicotine rush hinges on sugar in neurons

... look at part of the mouse nicotinic acetylcholine receptor (nAChR), one in a large and important group of mol...pe, Chen said. The water molecule may enable the receptor to alter its shape in counterbalance to the bending hinge, said Chen, who explained, “Think of it as...

Hormone helps mice 'hibernate,' survive starvation

... triggered in starving mice by a specific cellular receptor that controls the use of fat as energy, spurs a me...arvation and fasting. They focused on a nuclear receptor – a protein that turns genes on and off in the body – called peroxisome proliferator-activated recep...

How to lose weight and not go hungry: HU researcher develops drug that mimics feeling of 'fullness'

...is naturally excreted during eating and binds to a receptor in the brain called MC4R. When this “communication...ce in the blood, it could make its way to the MC4R receptor and “close the circuit” to send out the “full” signal. The result is that a person seriously wis...

Pesticides choke pathway for nature to produce nitrogen for crops

...f biology who focuses on phylogenomics and nuclear receptor genes. Fox and colleagues began detailing their findings in the journal Nature (2001) and Environmental Health Perspectives (2004), testing more than 50 chemicals, including pentachlorophenol (PCP), in in-vitro assays. The paper in PNAS reports th...

Migration alert -- How tumor cells home in on the lymphatic system

...es could be blocking the signaling molecule or its receptor on the tumor cell.”...

Endosome-mediated signaling in plants

...l cells over the past several years has shown that receptor endocytosis can actually facilitate signaling thro...ers show that the growth-promoting brassinosteroid receptor (BRI1) is trafficked through endosomes to enhance activation of this growth response pathway, which ...

Experimental gene therapy 'abolishes' arthritis pain and lessens joint damage

...e nutrients, toxins and hormones around them. Each receptor is designed to react with a specific signaling molecule, which docks into the receptor like a ship coming into port. The docking changes the shape of the dock to set off chain reactions i...

New research shows sharks use their noses and bodies to locate smells

...mal function of motion sensitive "hair cells," the receptor cells of the lateral line. At high doses it has been known to cause hearing and equilibrium problems in humans, senses that are also based on hair cells. Sharks with their lateral lines intact demonstrated a preference for the odor plume over the...

Detecting cold, feeling pain: Study reveals why menthol feels fresh

Scientists have identified the receptor in cells of the peripheral nervous system that is ... this case – that can cause pain. As such, the receptor – known as menthol receptor TRPM8 -- provides a target for studying acute and chronic pain, as can r...

'Personality-gene' makes songbirds curious

...ene (Drd4) carries the building instructions for a receptor in the brain, which forms the docking station for ...ne. Birds with a specific variant of this dopamine receptor D4 gene show a stronger exploratory behaviour than individuals with other variants (Proceedings of t...

Technique monitors thousands of molecules simultaneously

...hemical reactions and yield molecules that bind to receptor sites. Kevin Moeller, Ph.D., Washington University...ey mechanism where the molecule is the key and the receptor the lock. The nature and shape of molecules that serve as keys tells about the binding requirements ...

Nitric oxide: Key to cardiovascular and pulmonary function and drug effectiveness

...ether certain medications, such as beta adrenergic receptor agonists used in acute heart failure or in inhaler...turned-off by an enzyme called a G protein-coupled receptor kinase. This process is called desensitization and can limit the effectiveness of many drugs, such a...

8 plants from South Africa may hold potential for treating high blood pressure

...erting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB). These drugs not only lower blood pressure but offer additional protection to the brain and heart. ACEI, in particular, provide beneficial properties to patients with type 1 diabetes. In an effort to identify indigenous plants consu...

Newborn neurons like to hang with the 'in' crowd

...e newborn neurons' life-saving equipment. The NMDA receptor is activated by the neurotransmitter glutamate, a ...mit information to neighboring cells. Whenever the receptor picks up a glutamate signal it is stimulated and relays the signal. For young neurons that signal me...

Fat screen delivers plant-derived chemical with antidiabetic effects

...roduction called peroxisome proliferator-activated receptor ã (PPARã). "The current explanation for this paradoxical mode of action is the idea that the body needs a place to store lipids," Tontonoz said. "If the body becomes less able to store lipids in fat, it may deposit in other tissues," where it can ...

Molecule that destroys bone also protects it, new research shows

...eases. Therapies that target IL-17 or its cellular receptor currently are being developed. However, a UB mo... rats and mice as animal models, that blocking the receptor for IL-17 could be an effective therapy for RA and possibly for other autoimmune diseases such as mu...

Effect on breast tumors of DNA alternations in 3 genes described

...nes, known as E-cadherin, p16 and retinoic acid B2 receptor (RAR-B2), using tissue samples from 887 breast can... other genes, was more likely to occur in estrogen receptor (ER)-negative than in ER-positive tumors," said Tao. ER-positive tumors are those that express recep...

Deconstructing brain wiring, one neuron at a time

...ested the answer, which is based on an avian viral receptor that Young discovered as a postdoctoral fellow at ...e type we select will then express the avian viral receptor and the rabies virus protein, allowing the modified rabies virus to infect targeted cells and spread...

UCLA study uncovers clues for why Graves' disease attacks the eyes

...rom GD patients contain an abnormal surplus of the receptor targeted by this antibody. An antibody must latch to a specific receptor ?like a key into a lock -- in order to elicit a cellular response. The receptors mobbed the patient...

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