Scientists use gene transfer technology and common virus to block neuropathic pain
...amage showed much less pain-related behavior after receiving injections of the HSV-based vector, which contained a gene called GAD, or glutamic acid decarboxylase. The treatment's pain-killing effect lasted up to six weeks, and even longer in rats that received additional injections. The study is the first to...Freeze-dried mats of microbes awaken in Antarctic streambed
...gher growth rates than mats in adjacent streambeds receiving annual summer water flow, she said. The study showed the new microbial mats were taking up atmospheric nitrogen at a higher rate than mats in adjacent streambeds, increasing biomass productivity, she said. As photosynthetic bacteria, cyanobacteria ar...High carbon dioxide levels spur Southern pines to grow more needles
...recent six years of the FACE experiment, the pines receiving elevated CO2 had on average about 17 percent more ...ntreated pines. Higher needle percentages in trees receiving the gas were recorded even during years when forest soils were driest -- when both treated and untre...Scientists use gene transfer technology and common virus to block neuropathic pain in animals
...amage showed much less pain-related behavior after receiving injections of the HSV-based vector, which contained a gene called GAD, or glutamic acid decarboxylase. The treatment's pain-killing effect lasted up to six weeks, and even longer in rats that received additional injections. The study is the first to...Genomics researchers discover protein deficit that causes drug toxicity
...n really is, but it appears to play a role here by receiving misfolded proteins." Significance of the Research "Nobody has shown before that the aggresome plays a role in thiopurine metabolism, and it's a significant contribution," says Richard Weinshilboum, M.D., the Mayo Clinic researcher who first describ...Progress on HIV/AIDS significant but insufficient
...therapies in low- and middle-income countries were receiving them. He called for increased resources, better planning, better and more vocal leadership, and real investment in the empowerment of women and girls. Women now accounted for about half of all people living with HIV worldwide, but they were also the...Results of world's first gene therapy trial for arthritis show approach safe, feasible
...ckles in a double-blind fashion, with two knuckles receiving the gene-modified cells, and two knuckles receiving injections of cells with no added gene. One week later, at the time of the patient's previously sche...Opiate cocktail may spare cells from morphine's dark side
...howed, perhaps most importantly, that whereas rats receiving only morphine develop tolerance to the drug, those rats receiving the morphine/methadone cocktail did not show tolerance. Moreover, past work has not indicated whethe...Time and money make a difference in endangered species recovery
...ained by taxonomy and funding. Species reported as receiving more money from the U.S. Fish and Wildlife Service...h more likely to be improving or stable than those receiving less funding. This study emphasizes the need to consider the ways in which agencies administer and ......he sending neuron to another defined target on the receiving neuron. In contrast, the new data suggest that syn...mitter to reach receptors arrayed beyond the known receiving sites. The researchers say that right now they have little idea of how the synaptic shotgun function...NIH creates nationwide network of molecular libraries screening centers
...cis S. Collins, M.D., Ph.D. The nine institutions receiving grants as part of the Molecular Libraries Screening Centers Network (MLSCN) are: * Columbia University Medical Center, New York, New York; James Rothman, Principal Investigator; MLSCN Center at Columbia University * Emory University, Atlanta...Nicotine triggers the same brain reward circuitry as opiates
...ned mice to associate a specific test chamber with receiving nicotine, finding that the mice would prefer to stay in that chamber when given a choice. The researchers found that just placing the conditioned mice in the chamber activated CREB. They also found that naloxone blocked this conditioned increase in C...Nanoparticles carry cancer-killing drugs into tumor cells
...ceptor molecule called DR4. DR4 is responsible for receiving the signal molecule TRAIL, which initiates apoptosis in these cells. Prof. Krainer explains: "To begin with it was not evident what was missing in the signal transmission. The signal or the receptor molecule? To answer this question, we examined ten...Missing Receptor Molecule Causes Tumor Growth
...ceptor molecule called DR4. DR4 is responsible for receiving the signal molecule TRAIL, which initiates apoptosis in these cells. Prof. Krainer explains: "To begin with it was not evident what was missing in the signal transmission. The signal or the receptor molecule? To answer this question, we examined ten...Thinking the pain away? Study shows the brain's painkillers may cause 'placebo effect'
...activity increased when someone was told they were receiving a medicine to ease their pain. They then reported feeling less pain. The mind-body connection is quite clear." The findings are based on sophisticated brain scans from 14 young healthy men who agreed to allow researchers to inject their jaw muscles ...New type of rejection blocker protects kidneys after transplant
...was significantly higher at 12 months for patients receiving both the intensive and less intensive belatacept r...idney), also was lower at 12 months among patients receiving either of the belatacept regimens. Patients in all treatment groups had comparable total cholester...Doctors should stop prescribing antibiotics for the common cold, review advises
... been given either antibiotics or placebo. "People receiving antibiotics did no better in terms of lack of cure or persistence of symptoms than those on placebo," Arroll says. The goal of the study, according to the authors, was to determine if antibiotics reduce general cold symptoms such as sneezing, inflam...Sleeping Sickness Epidemic Spreading in Uganda
... the end of the third day, 71 percent of the women receiving misoprostol experienced complete uterine expulsion. After 5 more days had passed, a total of 84 percent of the misoprostol group had complete uterine expulsion. The misoprostol treatment failed for 16 percent of the group, however. In contrast, 3 per...Drug Offers Alternative to Surgical Treatment After Miscarriage
... the end of the third day, 71 percent of the women receiving misoprostol experienced complete uterine expulsion. After 5 more days had passed, a total of 84 percent of the misoprostol group had complete uterine expulsion. The misoprostol treatment failed for 16 percent of the group, however. In contrast, 3 per...Study shows humans have ability to track odors, much like bloodhounds
...ts, 16 in all, were able to tell which nostril was receiving a squirt of scent, but anosmic volunteers could only localize the trigeminal odorants, Sobel said. This shows that humans are able to localize odors through the olfactory nerves alone. "One possible objection is that the experimental set-up, with a ...