Scientists identify genetic pathways essential to RNA interference
...e report will appear in the journal Science and is receiving early online release on the Science Express website at http://www.sciencexpress.org. "The gene activation produced by RNAi is exquisitely specific, which gives it enormous potential for therapeutic application," says Gary Ruvkun, PhD, of the MGH Dep...Harmful chemicals may reprogram gene response to estrogen
...erous than those in genetically defective rats not receiving the DES treatment. "These data suggest that environmental exposures during development of the uterus can interact with a preexisting genetic susceptibility to increase the risk of disease," said Walker. "We are looking at a new kind of gene-environme...Strongest proof yet found for prion hypothesis
...d by Stanley Prusiner in 1982, and led to Prusiner receiving the Nobel Prize in Medicine in 1997. Until now, however, scientists have been unable to confirm its validity by causing a TSE in normal lab animals by infecting them with malformed proteins (dubbed "prions" by Prusiner) created entirely in a test tub...Gene therapy promising for growing tooth-supporting bone
... supporting bone around dental implants than those receiving the conventional treatment. "This study represents a proof-of-concept investigation. We are encouraged about the promise of this treatment," said Giannobile, also an associate professor of biomedical engineering and director of the Michigan Center f...Ophthalmologists implant five patients with artificial silicon retina microchip
...entually have. "Although we hope that all patients receiving the chip will experience some improvement in visual function, we can't say for sure how these patients will respond to this new treatment since this is still an experimental trial. If this study and future studies show safety and efficacy of the chip...Ophthalmologists Use Artificial Silicon Retina Microchip To Treat Vision Loss
...entually have. "Although we hope that all patients receiving the chip will experience some improvement in visual function, we can't say for sure how these patients will respond to this new treatment since this is still an experimental trial. If this study and future studies show safety and efficacy of the chip......tor nor the patient will know whether he or she is receiving the gene therapy or a placebo. For every three patients that receive the active gene, one will receive a placebo. Following treatment, patients enrolled in the study will be examined for chest pain at one month, three months and six months. A total o...Gene therapy for Parkinson's disease moves forward in animals
...-dopa production into the animals' striata. Before receiving the treatment, all animals had limited use in their left paws. After treatment, the animals receiving the therapeutic enzyme mixture show complete recovery in their paws. Researchers say not only did th...Circles Of DNA Might Help Predict Success Of Stem Cell Transplantation
...ing could help physicians predict whether children receiving such a transplant will experience either failure or significant delay in the reconstitution of the T cell population. Moreover, if the transplant is successful, T cells arising from donated stem cells will be available to launch attacks on the patien...Gene Therapy For Parkinson's Disease Moves Forward In Animals
...-dopa production into the animals' striata. Before receiving the treatment, all animals had limited use in their left paws. After treatment, the animals receiving the therapeutic enzyme mixture show complete recovery in their paws. Researchers say not only did th...Scientists identify genetic pathways essential to RNA interference
...e report will appear in the journal Science and is receiving early online release on the Science Express website at http://www.sciencexpress.org. "The gene activation produced by RNAi is exquisitely specific, which gives it enormous potential for therapeutic application," says Gary Ruvkun, PhD, of the MGH Dep...Placenta Is A Rich Source Of Blood Stem Cells
...leukemia and other blood diseases, and in patients receiving transplants, but growing them in quantity is difficult. The cells don't multiply readily in the laboratory, so they must be harvested from bone marrow by needle aspiration, a painful procedure, or coaxed into the blood and then collected. Both method...Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
...ease, Koeberl said. "A number of babies have been receiving enzyme replacement therapy for several years," said Koeberl. "They are walking, living longer, and meeting developmental milestones." Despite the early success of enzyme replacement therapy for some children with Pompe disease, a need for gene thera...Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
...eans that volunteers will notknow whether they are receiving the study drug or the placebo.The goal of the study is to determine if and how much GM-CSF willincrease the number of circulating EPCs in patients with peripheralvascular disease. Another goal is to find out whether or not increasingthe number of cir...