From a lowly yeast, researchers divine a clue to human disease
...g and hard or impossible for the cell to use. "It really messes up a lot of things, not just the read-through gene but also adjacent genes," Brow says. In other cases, Sen1 stop signs near the beginning of some genes normally prevent RNA polymerase II from making RNA from those genes. Sen1 mutations, on...Nanoscale microscope sheds first light on gene repair
...epair after DNA injuries to the region where it is really needed. Many biological processes lie out of the visual reach of scientists. The benefits of high-resolution electron microscopy are often offset by disruptive sample preparation requirements. Light microscopy allows easier sample prep and observat...From hot springs to rice farms, scientists reveal new insights into the secret lives of archaea
...tially the most abundant organism on Earth, yet we really had no idea how they survive in the ocean.'' Non-extremophilic Crenarchaeota are fascinating, according to Francis, in large part because of their potentially vital role in cycling the global supply of nitrogen. All living things need nitrogen to ...Artificial cornea offers better results for infants, some blind patients
... "These are children for whom, until now, there really has not been a good option. While this study is somewhat small and these children need to be followed for more time, we have decided that for now this is the treatment of choice for children who have corneas that are cloudy or opaque. It's either do ......but they usually are not very effective. "There really is no highly effective treatment available for this kind of severe pain, so having a new way to treat it is exciting," McIntosh says. If the new discovery eventually leads to a new pain drug that is combined with existing treatments, "you may be able...Biodegradable napkin -- featuring sensitive nanofibers -- may quickly detect biohazards
... this ready for the real world," Frey said, "but I really believe there is a place for this type of product that can be used by people with limited training to provide a fast indication of whether a biohazard is present." ...Nanoparticle assembly enters the fast lane
...ly of inorganic nano-objects. However, in order to really turn this attractive approach into nanotechnology,...sters, or aggregates, of gold particles. "It's really by design," Maye said. "We can sit down with a piece of paper, write out a DNA sequence, and control...When the label says 'low fat,' calories can pile up, study says
...n those who are overweight. They are at danger for really overindulging when they see something with a low-fat label. If we are looking for an excuse to eat, low-fat labels give it to us." He recommends that low-fat-labeled foods post larger, more realistic serving sizes, which might deter people from eat...Successful lung cancer surgery not enough to break nicotine dependence in many smokers
...f efficacy" for quitting, he says. "The thing that really drove whether or not people relapsed is whether they saw smoking as pleasurable and rewarding to the point that they can’t do without cigarettes, and they don’t believe they are able to quit." Patients who were able to quit by the one year mark wa...Biologists probe the machinery of cellular protein factories
...r latest results confirm that the ribosomal RNA is really the key to ribosome function. The proteins are also involved, but more peripherally," he said. To make a new protein, the genetic instructions are first copied from the DNA sequence of the gene into a messenger RNA molecule. The ribosome then read...Slow brain waves play key role in coordinating complex activity
... individual neurons in the cortex to find out what really generates the brain waves that EEGs and ECoGs measure. ...Scientists discover role for dueling RNAs
...n a higher cell type," says Hongay. "In fact, it's really the first time we've seen a gene regulate itself in this way." "For years scientists have evaluated genomes by measuring the sense RNA, with antisense transcripts thought to have no meaning at all," says Fink. "Here we've found a process in which...Mass vaccination unnecessary in the event of a large bioterrorist US smallpox attack
... of like unveiling the enemy to the point where we really understood it. This research has helped us demystify the threat a bit." Although smallpox has been eliminated as a naturally-occurring disease, the virus still exists in two approved laboratories in the United States and Russia. The Centers for Dis...Professors to develop hand-held pathogen testing device
... measure pathogens in a manner and at a price that really matters for human health," Hashsham said. "If we can screen for all pathogens together, we can minimize the threat significantly." Hashsham intends for the portable, hand-held device to be an all-in-one pathogen testing center where DNA amplifica...Research links 'ecstasy' to survival of key movement-related cells in brain
...se for developing new therapeutics," he added. "It really makes you rethink your own preconceptions." Dopamine is a neurotransmitter that has been found to regulate movement, balance, emotion and motivation, and it also affects pleasurable feelings in the brain. Researchers know that a loss of dopamine ce...Gene chip technology shows potential for identifying life-threatening blood infection
...ce who were sick with infection from mice who were really sick but did not have an infection," Cobb says. "We think this is an important first step to developing a similar test for human patients." Nine of these genes turned out to be common responders to inflammation and infection in mice. Some of these...Coral reefs are increasingly vulnerable to angry oceans
...versity of California, Santa Barbara. "However, to really predict how these events impact the dynamics of coral reefs we needed a way to quantify these vulnerabilities." The authors created the world's first engineering model to predict how much damage a reef is likely to suffer when confronted with the...PLoS ONE is launched by the Public Library of Science
...ve in its own right, but the power of this project really lies in what happens after publication. In almost all other journals, publication of a research paper is a full stop. The next significant step forward will be the publication of another paper following on from the previous work. But in PLoS ONE, as...Researchers reveal mystery of bacterial magnetism
... of our research, we realized that nobody had ever really demonstrated that being magnetic actually helps the bacteria." "Genetic modification allowed us to directly observe differences in behavior between magnetic and non-magnetic versions of the same bacterium," adds Professor Bruce Applegate. Professor ...... possible or probable Alzheimer's disease. This is really amazing because right now, there's just no treatment that works," says lead author Suzanne M. de la Monte, MD, MPH, a neuropathologist at Rhode Island Hospital and a professor of pathology and clinical neuroscience at Brown Medical School in Providen...