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Tag: "rat" at biology news

Brain protein improves stroke symptoms in rats, even when injected after 3 days

... the universities of Heidelberg and Erlangen, used rat models of two different types of stroke to assess the effect of an injection of G-CSF on recovery. The first model was used to assess the impact of G-CSF on the size of the brain area affected by the stroke, which is identified by the presence of...

A natural chemical found in strawberries boosts memory in healthy mice

...at fisetin activates the same signaling pathway in rat hippocampal tissues and also induces LTP. Next, they tested fisetin's effects in a so-called object discrimination test in mice. The mice get to explore two objects for a certain amount of time. The next day, one of the objects is replaced with a...

Beyond the book: Software automates access to brain atlases

...oscience Institute, author of the standard printed rat brain atlas, Brain Maps, Structure of the Rat Brain, (Elsevier Academic Press, 1992-2004) to produce the NeuroARt II viewer, following up on years of earlier development. "The entire design of our approach arose from practical methods" from Swanson...

U-M researchers use nanoparticles to target brain cancer

...ich healthy skin becomes sensitive to light. In rat studies, researchers found those treated traditionally with Photofrin survived 13 days, while rats treated with Photofrin incorporated into a nanoparticle survived an average of 33 days. Forty percent of the rats remained disease-free six months afte...

A new target for painkillers

...d to a hind paw with a blunt Teflon tip before the rat pulled away the paw. Normal rats could withstand 4.7 times more pressure before withdrawing their paws, compared with rats with sciatica. When cone snail toxin RgIA was injected, the rats with sciatica were able to tolerate a stronger touch from t...

A new approach to growing heart muscle

...perties. The approach uses a fibrin gel to support rat cardiac cells temporarily, before the fibrin breaks down as the cells organize into tissue. The U-M team details its achievement in a new paper published online in the Journal of Biomedical Materials Research Part A. And while BEHM is still yea...

Robotic whiskers can sense three-dimensional environment

...c whiskers that in many respects closely replicate rat whiskers." The technology, she said, could be used to extract the three-dimensional features of almost any solid object. Rat whiskers move actively in one dimension, rotating at their base in a plane roughly parallel to the ground. When the whiske...

Transplanted brain cells hold promise for Parkinson's disease

... transplant ?a long time in the two-year life of a rat - researchers found endogenous dopaminergic cells ...udies in test tubes, taking commercially available rat and human dopaminergic cells, exposing them to neurotoxins and then to stem cell factors. Stem cell ...

Widely used iron nanoparticles exhibit toxic effects on neuronal cells

...researchers used PC12 cells, a line derived from a rat pheochromocytoma. Nerve growth factor prompts PC12 cells to express a variety of neuron-specific genes and generate thin sprout-like cellular extensions called neurites, which are hundreds of times longer than the width of the cell, or up to several ...

Bacterial response to oxidation studied as toxin barometer

...nd more robust than using mammalian cells, such as rat brain tissue. Brain tissue is the most sensitive to toxins. We wanted to relate the bacteria response to cell response, like a barometer.? “And we saw that it corresponds well,?said Ikuma. “Something that sets the bacteria off also sets the cells o...

Engineering the heart piece by piece

... better properties. The gel was able to support rat cardiac cells temporarily, before the fibrin broke down as the cells multiplied and organized into tissue within a few days. Tests showed that the BEHM was capable of generating pulsating forces and reacting to stimulation more like real muscle than ...

Conceptualizing a cyborg

...ch-grown axons could grow when transplanted into a rat model of spinal-cord damage. The team is now is the midst of studies measuring neuronal electrical activity across newly engineered nerve bridges and the restoration of motor activity in experimental animals. ...

OHSU lab finds meth receptor that could lead to therapy

...onophosphate, or cAMP, inside cells expressing the rat TAAR1. Encouraged by this observation, Grandy's team explored the effects of these drugs on mouse TAAR1 and a human-rat TAAR1 hybrid and found all three receptors respond in similar ways. "The results of this study unequivocally demonstrate that m...

Metacognition: Faced with a test, rats can check their knowledge first

...oking their nose into one of two apertures. If the rat opted out of the test, it received a small food reward; if it opted in, it was subsequently presented with two levers, one of which it knew from past training represented "short duration" and one "long duration." Selection of the correct lever result...

Glucose triggers brain cell death in rats after hypoglycemic coma

...r that overshooting glucose levels is very bad for rat brains. The way we treat patients for hypoglycemia may have to be reevaluated." Swanson adds two strong cautions, however: "First, the work was done in rodents, and it is not legitimate to immediately extrapolate these findings to humans. Second, ...

Red flag for repetitive stress injuries identified for first time in humans

...rchers pinpointed these early warning signals in a rat model of RMI. The current study is the first to identify the warning signals in humans. For the study, they recruited 22 participants who were suffering from repetitive-stress injuries, including carpal tunnel syndrome, tendonitis, and other wrist...

Deconstructing brain wiring, one neuron at a time

...Wickersham. Experimenting on slices of neonatal rat brain, the Salk researchers inserted these two genes into selected neurons ?as well as a gene that fluoresces red when expressed. Then they applied the modified rabies virus, which had furthermore been given the ability to make infected cells fluores...

New Brandeis research sheds light on memory by erasing it

...induced and then biochemically erased in slices of rat hippocampus by manipulating a so-called "memory molecule," a protein kinase known as CaMKII. "The core problem in memory research has been understanding what the storage molecule actually is. Identifying this molecule is essential to understanding ...

8 plants from South Africa may hold potential for treating high blood pressure

...ivity. Plasma ACE activity was determined using rat plasma. The IC50 of the conventional ACEI, captopril was determined to test the sensitivity of the assay. At least three separate determinations were conducted for each test compound. A tannin test was only conducted on those plant extracts that exh...

Human stem cell treatment restores motor function in paralyzed rats

... This study builds on Marsala’s previous work in rat models using human neuronal stem cells, published in October 2004 in the European Journal of Neurosciences. In that study, significantly improved motor function, measured by a suppression of spastic movements and improved muscle tone, was shown in ...

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