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Tag: "rat" at biology news

New Technique for Tracking Gene Regulators

...ns of food butthe database of the human, mouse, or rat genome sequences. And becausethe scientists know that each of these tags lies within, at most, 500to 1,500 bases of a CREB-binding site, they are able to search theregion around the specific locations for CREB binding sequences orgenes that might be ...

Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems

...d four other institutions. The researchers used a rat model to explore the effects of growth hormone and another compound, IGF-1 (insulin-like growth factor 1) on adult rats and found paradoxical effects, according to William E. Sonntag, Ph.D., professor of physiology and pharmacology at Wake Forest Uni...

Beyond lithium for bipolar disorder

...tivated by this inhibition. They treated slices of rat brain with lithium chloride as well as a chemical ...lled GPR88, has been found to be associated with a rat model of mania, they said. This gene codes for a protein that is an "orphan receptor"--that is, its ...

PANTHER Protein Classification System Database 5.0

...ctional annotation information forhuman, mouse and rat genes in addition to the Drosophila genes. ThePANTHER system database consists of a library of 6,683 proteinfamilies, divided into 31,750 functional subfamilies, and coveringapproximately 90% of mammalian protein coding genes. The Web-basedinterface ...

Rats infected as newborns grew up vulnerable to memory problems during an immune challenge

...am led by Staci Bilbo, PhD, injected a group of 49 rat pups on postnatal Day 4 either with the common int...ry about 60 days after birth. To test memory, each rat was allowed to explore a novel experimental chamber for several minutes on the first day. On the sec...

Single stem cells from bone heal a broken heart

... a large population, they were transplanted into a rat model of myocardial infarction. This improved cardiac function because the cells stimulated release of growth factors and anti-apoptotic agents that, in turn, increased the proliferative potential of cardiomyocytes and enhanced survival of host myoca...

Revolutionary nanotechnology illuminates brain cells at work

...t proteins, we placed the sensor on the surface of rat hippocampal cells. The hippocampus is the part of the brain that is involved with emotional reactions, and it helps store learned information in memory. When neurons are activated, they secrete glutamate, and we could see this activity under the micr...

Researchers make surprise discovery that some neurons can transmit three signals at once

... University of Pittsburgh discovered that immature rat brain cells could fire a simultaneous three-punch ...ter birth marks a critical phase in the developing rat brain, a time period comparable to three months gestation in a human, when neurons are meticulously ...

UCSD medical/bioengineering reseachers show titanium debris satobtage artificial joints

...affected the bonding strength of pins implanted in rat thighs. The pins were shown to come out more easily when the titanium particles were present, with the smallest and largest particles causing the greatest weakening. The researchers demonstrated how different-sized titanium particles affected bone-bu...

Ariadne Genomics Announces the Release of PathwayStudio?Central, Client-Server Software for Biological Pathway Analysis

...et?database of functional relationships for human, rat and mouse contains 52,000 annotated mammalian proteins, 40,000 chemicals, and over 500 thousand total functional relationships, among which there are 42,000+ physical protein-protein interactions, 46,000+ facts of gene expression regulation, and abou...

Structure-building cell signals also may influence learning and memory

...n cancers. By inserting chicken ephrin genes into rat cells, Fumitoshi Irie, Ph.D., Professor Yu Yamaguc... in cells that were not altered genetically. Using rat brain cells, they found that increased signaling did indeed create more vesicles in normal cells. Mo...

NHGRI targets 12 more organisms for genome sequencing

...seases, diabetes and cancer. Building a catalog of rat SNPs will assist researchers trying to find geneti... that may be involved in human disease. The eight rat strains selected are the PVG strain, commonly used as a healthy control in studies; the F344 strain,...

Precise Timing Enabled Pig-to-rat Transplants To Cure Diabetes

...hen the primordia mature, they replace the missing rat insulin with pig insulin, returning the rats' blood glucose to normal levels. "The absence of a need for immune suppression after transplanting from one species to another was such an unexpected and encouraging discovery that we wanted to find out m...

Researchers develop promising new gene network analysis method

...wn's Center for Genomics and Proteomics, developed rat cells that lacked the c-Myc gene. These cells were further modified to make a form of the c-Myc protein, which could be switched on or off by the hormone treatment tamoxifen. One batch of cells was treated with tamoxifen, then harvested one, two, fo...

Bees, Brains and Addiction

...on the behavior of humans and other animals that a rat will work so tirelessly when it is rewarded with electrical stimulation to this region of the brain that it can forgo eating and ultimately starve to death. The neurobiology and evolutionary basis of the brain circuitry that processes information ab...

Discoveries by UAB and Florida scientists may help transplanted organs survive longer

...olid organ transplants. The study, carried out in rat models, also showed that a single muscular injection of the molecule, interleukin-10 (IL-10), carried in a gene delivery vector, or mechanism, could provide long-term therapeutic effects. Anupam Agarwal, M.D., director of the UAB Nephrology Research...

Multi-species genome comparison sheds new light on evolutionary processes, cancer mutations

...k full advantage of the wealth of human, mouse and rat genome sequence data generated by the recently completed Human Genome Project." Chromosomes are the threadlike "packages" of DNA located in the nucleus of each cell. When cells divide, a chromosome occasionally breaks and the fragment can get stuck ...

Retroviral resistance gene found

... level of FEZ1 expression in a specific laboratory rat cell line caused a significant block to retroviral infection ?retroviruses were able to enter the host cells and synthesize the viral DNA, but were excluded from entering the host cell nucleus. "We suspect that the overexpression of FEZ1 interferes ...

3D Atlas Will Help Navigate The Spinal Cord

...n to prepare a three-dimensional (3D) atlas of the rat spinal cord over the next two years. Christopher ...ses, being the author of atlases of human, monkey, rat and mouse brains used world-wide by neuroscientists in all areas. As a geographic map to a travelle...

UIC researchers show protein routes messages in nerve cells

... these mechanisms in a mammal such as a mouse or a rat can help researchers understand how nerves need to be reconnected after spinal cord injury, or may open doors to developing drugs that can manipulate proteins that cause neurological diseases in humans. ...

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