Patients now surviving once-fatal immune disease
...ng disease by age 15. We and other physicians were quite surprised at how well these patients are doing with the proper care." XLA is a rare disease that is inherited through a mutation in the Btk gene on the X-chromosome--one of the two types of sex chromosomes. Males with this disease have very low lev...Flu not the only germ threat this time of year
...door handles, and change from the coffee shop, for quite awhile, for at least a day. If you put your finger in your mouth, or touch your eye, or pick your nose, you're a spreader, to put it bluntly. People share cell phones, they shake hands to be social. These are effective ways to transmit disease." Whi...St. Jude projects 90 percent cure rate for ALL
...arch Professor. "A 90 percent cure rate for ALL is quite possible in the near future if we continue to incorporate the breakthroughs of past decades and successfully overcome the remaining challenges." The dramatic increase in cure rates for children is especially significant in the case of African-Ameri...Losing sleep undoes the rejuvenating effects new learning has on the brain
...ew things, at least in the case of spatial memory, quite literally keeps your brain young by ensuring a better survival rate for new brain cells in the hippocampus. However, not getting enough sleep eliminates the potential benefit of new learning on the hippocampus by suppressing neurogenesis. "Mild, chro...UC Riverside psychologist explores human perception, finds 'wow factor'
...that they can." Rosenblum has given test subjects quite a few such surprises. For example, participants in his work have shown that they can determine the locations of objects by listening to echoes as noise bounces off them. Other test subjects have used room echoes to figure out where they are on campus......sperm without success," said Clapham. "We had been quite frustrated by it. However, Yuriy finally discovered a way to patch clamp the cells, which was central to the success reported in this paper." Basically, Kirichok found that he could patch clamp the pipette into a microscopic "cytoplasmic droplet" tha...Retinol for combating leukemia cells
...s (e.g. those of the skin) but they turn out to be quite poisonous in the doses required ?they are not well tolerated. This is why synthetic retinoids are created. Specifically, the University research team analysed the effect of retinamide in certain types of leukemia - lymphoblastic leukemias. Nowadays,...BioMed Central launches Biology Direct
...e worth its salt knows that the discussions can be quite vigorous, often enough going to bare knuckles, esp...tand criticisms that would otherwise have remained quite obscure. And a couple of misunderstandings were cleared up very rapidly rather than having to spend ...Faults in newly discovered breast stem cells may lead to tumours
...research, the discovery of the breast stem cell is quite profound and will most likely form the basis of research in the area for years to come. The ultimate objective is to create a drug that will, in effect, switch off breast cancer cells. To do this, the exact makeup of genes expressed by normal and r...Loosen leash on cancer protein 'watchdog,' researchers say
... conception to produce higher p53 levels, which is quite a different treatment than just giving normal mice a pill," Mendrysa said. "Also, mice in our study are not subject to the same stresses as, for example, a person working on Wall Street. It remains to be seen whether higher p53, in conjunction with o...More evidence mammals, fruit flies share make-up on function of biological clocks
...t the role of one protein--Cryptochrome (Cry)--was quite different between flies and mammals. In fruit flies, Cry is a circadian photoreceptor, which helps light reset the biological clock with changing seasons, or in jet lag-style experiments (in which light is manipulated to mimic the experience of trave...Newly discovered killer cell fights cancer
...s to its messenger function, the transformation is quite astonishing," says Pardoll. The cell sprouts long, hairy tentacles called dendrites. It uses its "arms" to increase the amount of surface area it reaches to communicate and interact with other immune cells. In the next step of their investigation, ...Landmark discovery of a Kaposi's sarcoma-associated herpesvirus receptor
...med Moritz Kaposi in 1872, it was considered to be quite rare--a medical curiosity usually found in particular populations such as older Italian men, transplant patients and young men in certain parts of sub-Saharan Africa. But then at the dawn of the AIDS pandemic in the early 1980s, the small purplish Ka...Proteins stop blood-vessel and tumor growth in mice
...ust effect. We further expect the mice to tolerate quite large doses of the fibulins, which makes us hopeful that toxicity will not be a problem." The researchers have not yet discovered what receptors the fibulins interact with to produce their anti-angiogenic effect. But in the current paper, they repor...Predicting successful outcomes in living-donor liver transplants
...ultiple blood sampling used by the second study is quite labor intensive when compared to the device used in the first study, which is more apt to make its way into clinical practice. He concludes: "Before clinical decisions are based upon any of these tests, however, confirmation of the findings in larger...Stem cells can repair torn tendons or ligaments
...e recent progress demonstrated in these studies is quite remarkable and may be potentially useful in cell-based therapeutic approaches to musculoskeletal injuries." ......dson Sr., BTU chairman and founding member. "It's quite rewarding to uncover new information like this that bonefish may be crossing the Gulf Stream. It's what truly can lead to better understanding and managing of our fisheries." This research is made possible through assistance from the Florida Keys F...Trial success for diabetic nerve therapy
...f Life Sciences. "Our approach to gene therapy is quite different to previous attempts at treatment: we use a DNA-binding protein called ZFP TFTM to poke life into the patient's own genes and produce a growth factor that has a role in nerve protection and regeneration. "As the data in the paper demonstra...Major obesity gene is 'lost in the shuffle'
...letion occurred between two pieces of DNA that are quite abundant in primate genomes, called Alu elements," explains Nakayama. "We located one copy of a specific Alu element on either side of the ASIP gene. Our study shows that during the evolution of gibbons, these Alu elements lined up and recombined...UC Davis study finds HIV hiding from drugs in gut, preventing immune recovery
...l study to show that, while current HIV therapy is quite successful in reducing viral loads and increasing T-cells in peripheral blood, it is not so effective in gut mucosa," said Satya Dandekar, professor and chair of the Department of Medical Microbiology and Immunology at UC Davis Health System and seni...