Learning to fight an adversary that won't stay down
...e largely failed to deliver the hoped-for knockout punch breakthrough against the defences of disease-causing bacteria, says a leading Canadian specialist in antibiotic resistance. Techniques such as genomic sequencing and high throughput screening were expected to make the development of new antibiotic c...Probing The Promise And Perils Of Nanoparticles
...r work, U-M researchers discovered that dendrimers punch nanoscale holes in cell membranes, making the memb... suggest that the same types of nanoparticles that punch holes in model membranes also damage membranes in living cells and make the membranes more permeable...Rats infected as newborns grew up vulnerable to memory problems during an immune challenge
... system challenge. The relatively uncommon one-two punch seems to cause the problem, although researchers don't know how long it lasts. Still, says Bilbo, "This may go far to explain some of the individual variability in disease susceptibility, other than genetic variation, in animals in the wild and perha...Probing the promise and perils of nanoparticles
...r work, U-M researchers discovered that dendrimers punch nanoscale holes in cell membranes, making the memb... suggest that the same types of nanoparticles that punch holes in model membranes also damage membranes in living cells and make the membranes more permeable...Treatments have same target, different responses for lung cancer patients with genetic mutation
...ther drugs. "Cetuximab may still have an effective punch if the right circumstances can be identified," the authors conclude. ...World shark attacks dipped in 2005, part of long-term trend
...resence of mind to drive it away with a well-timed punch to the nose, he said. "That gentleman did precisely what he should do under those circumstances," Burgess said. "A person who is under attack should act aggressively toward the shark and not follow the advice given to women who are having their purs...Viral protein is an effective preventative against infection
...ted the bacteria and replicated, it uses lysins to punch holes in the bacteria’s cell wall, killing the bacteria, in order to escape. Fischetti’s lab has studied many different lysins and found that they work even from outside the bacterial cell as well as from the inside. In addition, unlike antibiotics, ...Knocking out survival protein could aid leukemia treatment
...isting drugs might also offer an effective one-two punch against drug-resistant forms of chronic lymphocytic leukemia (CLL) and acute lymphoblastic leukemia (ALL). The two forms of cancer kill about 20,500 Americans yearly. The survival protein is called Mcl1. It usually helps keep normal cells healthy...Scientists genetically engineer tomatoes with enhanced folate content
...greens and beans aren't the only foods that pack a punch of folate, the vitamin essential for a healthy start to pregnancy. Researchers now have used genetic engineering--manipulating an organism's genes--to make tomatoes with a full day's worth of the nutrient in a single serving. The scientists publishe...Leeches ferry infection among newts
...g bloodsucking leeches may be delivering a one-two punch to newts, according to biologists, who say the discovery may provide clues to disease outbreaks in amphibians. The findings could also lead to a better understanding of diseases affecting humans, such as malaria, chagas disease and sleeping sickness...New vaccine prevents CMV infection and disease in mice
..., the researchers devised a vaccine with a one-two punch that combines a DNA immunization that targets T-cells to essential genes required for CMV replication, with a killed virus that prompts the body’s B-cells to generate an antibody response. The vaccine contains the DNA of two essential genes tha...Ice Age extinction claimed highly carnivorous Alaskan wolves
... end of the Ice Age may have packed an even bigger punch than scientists have realized. To the list of victims such as woolly mammoths and saber-toothed cats, a Smithsonian-led team of scientists has added one more: a highly carnivorous form of wolf that lived in Alaska, north of the ice sheets. Wolves w...