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Tag: "pull" at biology news

Discovery of key protein's shape could lead to improved bacterial pneumonia vaccine

...hatit looks like and how it’s put together, we can pull it apart to see ifsmaller pieces of it can be used to make a vaccine that triggersproduction of antibodies against the CbpA. Since all the S. pneumoniaestrains need CbpA to invade the bloodstream, we can widen theprotection of a vaccine to all 90 typ...

New comparative toxicogenomics database

...hatit looks like and how it’s put together, we can pull it apart to see ifsmaller pieces of it can be used to make a vaccine that triggersproduction of antibodies against the CbpA. Since all the S. pneumoniaestrains need CbpA to invade the bloodstream, we can widen theprotection of a vaccine to all 90 typ...

Same mutation aided evolution in many fish species, Stanford study finds

...searchers sometimes need to put on the hip waders, pull out the fishing net and go learn how their theory compares to the real world. According to a Stanford University School of Medicine study published in the March 25 issue of Science, Mother Nature is more predictable than lab experiments suggest. In ...

The Bacteria's guide to survival

...le. They then showed that an artificial mechanical pull on the host cell membrane could trigger a signaling cascade in the host cells to affect the host's gene expression. Many of the genes that increased in activity due to the tugs were already known to regulate apoptosis and cellular response to stress...

15-year hunt finds cause of pseudothalidomide syndrome

..."motors" attach to the centromere of each copy and pull the original and the new copy away from each another as division proceeds. However, in cells from people with Roberts syndrome, the chromosome copies are frequently not attached to each other at their centromeres and the chromosomes don't get lined ...

Pair of cancer genes found to drive both cell migration and division

...re to destroy PIP3 at the furrow, the halves can't pull apart," says Chris Janetopoulos, Ph.D., a research associate in Devreotes's lab and first author on the paper. The cells' problems were eliminated when the researchers added the human PTEN gene to the mutated amoebae. Like the amoeba's own PTEN, the ...

Disabling gene defuses rheumatoid arthritis in mice

...as apoptosis. Damaged or highly stressed cells can pull their own plug in this or a similar manner to prevent themselves from becoming cancerous. "It seems that evolution has somehow provided protective mechanisms for innate immune cells when they go into the hazardous inflammatory environments they crea...

UNC plant researchers discover proteins interact to form hair-trigger protection against invaders

...nce antenna or hair trigger. When disease invaders pull that trigger, infected plants cells quickly commit suicide, often preventing the invader from destroying the entire plant. The new discovery appears to be a universal mechanism for defense by all plants against not only bacteria and viruses, but als...

FDA approves more generic AIDS drugs

...nce antenna or hair trigger. When disease invaders pull that trigger, infected plants cells quickly commit suicide, often preventing the invader from destroying the entire plant. The new discovery appears to be a universal mechanism for defense by all plants against not only bacteria and viruses, but als...

'Underground' tunnels discovered as means for communication between immune system cells

...e tip, and before Dr. Watkins realized the need to pull away from the cell, he had already given it a jab. "On the screen it looked like flash bulbs going off in a dark concert arena," Dr. Salter recalled of that moment, when to both their great surprise the researchers witnessed how that little mishap h...

Two designer drugs hit same lung cancer target, but only one is effective

... of inhibiting the mutant EGFR receptor, you would pull Iressa and Tarceva off the shelf, not Erbitux." Iressa and Tarceva are known as small-molecule drugs that can be taken orally and block the part of the EGFR molecule that's located within the cell. In NSCLC, patients with the mutation often respond ...

Clearing jams in copy machinery

...are bound simultaneously to the beta clamp, it can pull either of the polymerases out if its toolbelt as needed. O'Donnell and his colleagues propose two explanations for how the polymerase switch is controlled. "One possibility is that the beta clamp may sense when Pol III stalls, triggering a change i...

Drugs from the deep blue

... structure with the same properties. This work can pull in techniques from different areas of chemistry and biochemistry, but the pathways used to make these products naturally are far too complex to reproduce with current genetic engineering techniques, Molinski said. One of their finds is phorboxazole,...

Logging doubles threat to the Amazon, rivaling clear-cutting, study suggests

...ons as well. Vines threading through the trees can pull down large amounts of vegetation when a tree falls. The forest also becomes drier and more flammable, as the shady canopy is thinned. "Logged forests are areas of extraordinary damage," Asner said. "A tree crown can be 25 meters. When you knock down...

Researchers know what you were about to say; fMRI used to detect memory storage and retrieval

...lost memories involves using a part of a memory to pull out the entire thought, much like when you try remember where you put your keys last night," Polyn said. "If you recall that you were washing dishes, that might trigger associated memories, leading you to remember that your keys are next to the sink...

Marathon of nano-sprinters

...in a directed fash-ion along filaments, the motors pull cargo particles which are much larger than the mo-...nts are immobilized on a surface. Molecular motors pull latex beads along these filaments, and the movement of the beads is observed under the microscope. ...

Researchers make long DNA 'wires' for future medical and electronic devices

... Guan describe how they used a tiny rubber comb to pull DNA strands from drops of water and stamp them onto glass chips. Other labs have formed very simple structures with DNA, and those are now used in devices for gene testing and medical diagnostics. But Lee and Guan are the first to coax strands of DN...

New technique puts brain-imaging research on its head

...essels, membranes and nerves at the base, tries to pull away from all those attachments, leading to a sign...ar. It seems to be because the brain is trying to pull away from some constraints in the front of the brain." Bayly and his collaborators can apply the le...

Picking apart how neurons learn

...ndings, published in the March 16 issue of Neuron, pull together a growing body of evidence from the field. The study shows definitively that interactions between the PICK1 protein and another group of proteins known as AMPA receptors are critical for specific neurons, called Purkinje cells, in the lower ...

Learning to love bacteria: Stanford scientist highlights bugs' benefits

...tions have been made without necessarily trying to pull it all together," said Falkow. "So what I tried to do in this article is to point out that the continued presence of these organisms in human society may actually be beneficial to the host and that is why they are tolerated by the immune system." It...

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