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A gene's first 'kiss' sets off that affair known as puberty

...lamus just as puberty begins, according to a study published in this week's online edition of the Proceedings of the National Academy of Sciences (PNAS). Until now, little had been known about what instigates the cascade of hormone secretions that, over time, produces puberty's tell-tale physical changes, i...

Chemists create 'Superbowl' molecule; May lead to better health

...procedures, the investigators say. Their study was published in the Dec. 29 print issue of the journal, one of the peer-reviewed publications of the American Chemical Society, the world's largest scientific society. The superbowl molecule belongs to a class of artificial bowl-shaped molecules that were first ...

DNA Molecules Used To Assemble Nanoparticles

...th each successive step of synthesis. For a paper published Jan. 21 in the journal Chemistry and Biology, U-M Biomedical Engineering graduate student Youngseon Choi built nanoparticle clusters of two different functional dendrimers, one designed for imaging and the other for targeting cancer cells. Each of th...

Bioartificial kidney under study at MCG

...ulating inflammatory mediators. Study results were published in the October 2004 issue of Kidney International. The trial now underway is looking at the efficacy of the device over 72 hours, although researchers say that if the device is eventually approved by the Food and Drug Administration, it likely would...

Association of herpesvirus with lung disorder questioned

...trast with those in a much-publicized 2003 article published in The New England Journal of Medicine that reported the presence of the virus in similar samples of lung tissue from a similar number of patients. Both primary pulmonary hypertension and infection with HHV-8 are uncommon, Katano and co-authors ex...

Man and mouse share genome structures

...IT and Harvard, and Affymetrix. Their findings are published in the January 28, 2005 issue of Cell. "Now that the human genome has been sequenced, it is vital to learn how the genome is translated to make living cells and organisms, and how we can use that information to improve human health," said Bernstein,...

Molecular biology fills gaps in knowledge of bat evolution

...ia, Riverside Biology Professor Mark Springer, has published a paper in the Jan. 28 issue of the journal Science that uses molecular biology and the fossil data to fill in many of the gaps. Springer coauthors the paper, titled A Molecular Phylogeny for Bats Illuminates Biogeography and the Fossil Record, with...

Genes In The Interferon System Important In Systemic Lupus Erythematosus

...nces at Uppsala University. The findings are being published todayon the Web page of the highly prestigious American Journal of HumanGenetics. "These findings are probably the first genetic pieces of ahuge 'interferon puzzle,' with whose help it will be possible todiscover the mechanisms behind the disease SLE...

UAB scientists discover the origin of a mysterious physical force

...haviour was discovered by the same researchers and published in Physical Review Letters in April 2004. The sci...n films form in detergents. The discovery has been published in today's edition of Physical Review Letters. Water is the solvent in which most physical, chemica...

Researchers discover way to make cells in the eye sensitive to light

...y switching on a single gene.According to research published online today in Nature, the team fromImperial College London and the University of Manchester, havediscovered that activating the melanopsin gene in the nerve cellscauses them to become light responsive, or photoreceptive. Usingmouse cells, the rese...

Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants

... Localization of a SmallPlant Adhesion Protein?and published in the January 2005 issue ofNanotechnology, and is a featured article at http://nanotechweb.org.Journal Nanotechnology has an international readership among academic,government and corporate sectors, and is dedicated to coverage of allaspects of nano...

Source of molecular triggers in cutaneous T cell lymphoma identified

In a study published in the journal Blood, Yale scientists identify the molecular triggers that stimulate Cutaneous T Cell Lymphoma (CTCL) cells to clonally expand into large populations of malignant lymphocytes. CTCL is the most common adult malignancy of T lymphocytes...

Protein discovery could unlock the secret to better TB treatment

...cts around 10 to 15 people every year. In a study published on 1st March 2005 in Nature Structural & Molecular Biology, a combined team discovered the structure of a protein known as resuscitation promoting factor (Rpf). Five versions of the Rpf protein exist in TB bacteria. The paper's unveiling of the m...

Columbia research lifts major hurdle to gene therapy for cancer

...process of eradicating cancer cells.In a new study published in the Jan. 25 issue of the Proceedings of theNational Academy of Sciences (PNAS), the researchers demonstrated thatthe technique works by incorporating it into a specially designedvirus. The virus eradicated prostate cancer cells in the lab and inan...

Dysentery uses 'sword and shield' to cause infection

...pproach to cause infection. According to research published today in Science, the team from Imperial College London and Institut Pasteur, Paris, found that shigella, the bacteria which causes dysentery, is able to invade cells, while stopping any response from the immune system. They found that shigella was ...

Priming embryonic stem cells to fulfill their promise

...nt, described the cell-culturetechnique in a paper published in the February issue of Nature Methods,which became available online on Jan. 21. Embryonicstem cells are considered the blank-slate, raw material needed torepair or replace damaged or missing liver, nerve, muscle, and othertissues and organs. Howev...

New binding target for oncogenic viral protein

...ancer-preventing proteins, p53 and pRb. In a study published in the Journal of Biological Chemistry, researchers at the Fred Hutchinson Cancer Research Center report the discovery of an additional target for T antigen--a protein called Fbw7. The Fbw7 gene is located in a chromosomal region that is deleted in ...

Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas

...striction and low birth weight. The Joslin study, published in the March edition of Diabetes, reinforces what scientists have known from previous studies in humans: Infants with low birth weight -- typically defined as under five and one-half pounds -- have a higher risk for developing type 2 diabetes. To un...

Controversial drug shown to act on brain protein to cut alcohol use

...ecreases alcohol consumption.The research is being published in the January 19 issue of The Journalof Neuroscience."By identifying the brain protein that Ibogaine regulates to reducealcohol consumption in rats, we have established a link between GDNFand reversal of addiction -- knowledge of a molecular mechani...

Current human embryonic stem cell lines contaminated UCSD/Salk team finds

...e Salk Institute in La Jolla,California.In a study published online January 23, 2005 in the journal NatureMedic...egenetically unable to make it. In a related paper published November29, 2004 by the Journal of Biological Chemistry (JBC), the Varki grouphas also discovered th...

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