New research to cut animal testing
... "The testing process developed at Gentronix has proven very reliable at telling us whether a drug will cause cancer but some chemicals, called promutagens, only become carcinogenic once they have passed through the body's liver. "This grant will help us develop new non-animal experiments to identify t...Research holds promise for herpes vaccine
...e or cause disease. However, subunit vaccines have proven ineffective in protecting people against persistent infections like genital herpes and AIDS, Halford said. "From a theoretical standpoint, subunit vaccines are poor mimics of a natural virus infection," Halford said. "There's not enough there for o...Male circumcision reduces HIV risk, study stopped early
...s of Asia," Bailey said. "However, there are other proven health benefits of circumcision, including better ...mall, according to Bailey. The only other strategy proven effective is the use of antiretroviral drugs to reduce transmission from mother to child. If a si...New HIV statistics indicate increasing toll of AIDS on African American community
...isk of infection from sharing needles. Expand proven HIV prevention, diagnosis and care programs. ?Far too many African Americans lack accurate information about how HIV is transmitted, prevented and treated. Approximately 250,000 Americans ?many of them African American ?are unaware that they have HIV...Researchers create genetically matched embryonic stem cells for transplantation
...might not function normally. "This technique, if proven effective in humans, offers an efficient way of generating customized stem cell lines from women," says George Q. Daley, MD, PhD, senior author on the paper, who is the Associate Director of the Children's Hospital Boston Stem Cell Program and a memb...Innovative movies show real-time immune-cell activity within tumors
...pite a few remarkable successes, these trials have proven frustratingly uneven. Greater insights into the mechanisms of interaction between T cells and tumor cells could provide vital new information to advance these efforts. "Through adoptive transfer," Weninger explains, "we were able to compare two sit...Therapeutic role found for carbon monoxide
...from auto exhausts and faulty heating systems ?has proven effective in treating the symptoms of pulmonary arterial hypertension (PAH), an extremely debilitating condition that typically leads to right heart failure and eventual death. The new findings, made in an animal study led by researchers at Beth Isr...Technology for monitoring fetal oxygen during labor offers no apparent benefit
...ation monitoring until the new technology could be proven effective. The current study was designed to settle unresolved questions about the new technology. With fetal oxygen saturation monitoring, a sensor is inserted by hand through the cervix, after the membranes have ruptured, and placed against the...Cloning techniques produce FDA-approved antibiotic
...treatment of various bacterial infections, and has proven effective for the treatment of infections that have become resistant to the antibiotics penicillin and vancomycin. Fosfomycin is a member of a class of compounds called phosphonic acids because they contain a carbon-phosphorous bond. Fosfomycin fun...Most widely used organic pesticide requires help to kill
...posed as a hypothesis in one paper became cited as proven in another and no one seemed to go back to the original literature until now." Handelsman is a Howard Hughes Medical Institute Professor in the UW-Madison department of plant pathology. The new work, conducted in the laboratories of Handelsman an...Dopamine drug leads to new neurons and recovery of function in rat model of Parkinson's
...less effective with time. There are no treatments proven to slow or halt the course of PD. However, many researchers have been trying to find ways of replacing the lost neurons. One possible way to do this would be to transplant new neurons that are grown from embryonic stem cells or neural progenitor c...AIDS vaccine research offers new insights on survival
...rs ago, the human immunodeficiency virus (HIV) has proven extraordinarily difficult to control. Attempts to develop an HIV vaccine that triggers the production of antibodies -- the mechanism responsible for vaccine protection against other viruses including polio and hepatitis B -- have been unsuccessful. ...Science captures the essence of fruit
...al biotechnology applications." HortResearch has proven the bioproduction concept can be used to produce fruit flavours and fragrances by perfectly recreating a fruit compound called alpha-farnesene, responsible for the distinctive aroma of green apples. The company has filed international patent applic...Adult stem cell research at UB targets damaged hearts
...trong immune response. "If this characteristic is proven rigorously," he said, "and if we determine how these stem cells differentiate into cells for specific 'jobs,' it might provide the basis for 'off-the-shelf' use of these stem cells in future therapeutic applications." The second phase of the proje......are first to reconstruct an ancient gene. ?We have proven that from two specialized modern genes, we can reconstruct the ancient gene they split off from. It illuminates the mechanisms and processes that evolution uses, and tells us more about how Mother Nature engineers life." The ability to reconstruct...First-ever genomic test predicts which lung cancer patients need chemotherapy to live
...e with 90 percent accuracy, the study showed. If proven to be effective in the clinical trial, the test will replace the current method of assessing risk, which is imprecise and provides only a broad estimate of a patient's risk, said Joseph Nevins, Ph.D., a professor of molecular genetics at Duke and sen...Novel therapy combinations gain ground in treating hepatitis
...l hepatitis. Serum samples from 72 patients with proven hepatitis A or B that had progressed to liver failure were tested for APAP adducts, which are the toxic byproducts of acetaminophen liver damage, created when a chemical (in this case, acetaminophen) binds to proteins in the liver that are then relea...Adult stem cells are touchy-feely, need environmental clues
...es. For the first time, the Penn researchers have proven that the physical microenvironment is also crucial for guiding the cells through differentiation. According to Adam Engler, the first author on the study and a graduate student in the School of Engineering and Applied Science, soft microenvironment...U of M researchers find immune-activating cells in intestines
...of cells in the intestinal system of mice that are proven to turn on T-cells, cells that help fight infection. The research will be published in the May 2006 issue of the journal Immunity, released today. "This connection between the group of cells and immune response will help in studying and developing ......cautioned that the findings "have not by any means proven that this mechanism of pathology or the compounds that affect it are relevant to humans. However, given the fact that we've found the same results in yeast, flies, worms and rat neurons, I would be very surprised if we didn't find that they were rele...