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Tag: "proteasome" at biology news

Compound from marine bacteria shows potential as multiple myeloma therapy

...r cells' proteasomes from working effectively. The proteasome work as a cell's "garbage disposal," chewing up and disposing of old, unwanted proteins. With their proteasome jammed, cells die from the backup of damaged proteins. "Proteasome inhibition is a key therapeutic ...

MIT research holds promise for Huntington's treatment

...mpound also had a strong protective effect against proteasome disruption, thus blocking one of the toxic effects of the huntingtin protein. The B2 compound also promoted large inclusions and showed a protective effect in a cellular model of Parkinson's disease, another neurodegenerative disorder caused by misf...

Johns Hopkins lab scientists tame overactive CF protein

... latches onto the damaged CFTR and sends it to the proteasome for destruction," Zeitlin says. "Using RNA interfe...by the use of RNA interference was superior to the proteasome inhibitor, researchers found. Both the drug and RNA interference also staved off inflammation cause...

Brain enzyme treatment relieves memory lapse in Alzheimer's mice

...th Alzheimer's after death found evidence that the proteasome remained intact but largely unable to degrade prot... cascade that results in the partial inhibition of proteasome activity more rapidly than is likely as the result of the accumulation of misfolded or undigestable ...

Study reveals how cells destroy faulty proteins in cystic fibrosis

...asome. This trash system is known as the ubiquitin proteasome pathway. "We've identified the trash collectors that recognize misfolded proteins, decide if they might be toxic to the cell and mark them with ubiquitin. The ubiquitinated proteins, including faulty CFTR, are then degraded or shredded by the pro...

MIT finds most complex protein knot ever seen

...rolase may prevent it from getting sucked into the proteasome as it works, Mirny said. The researchers hypothesi...oteins with complex knots can't be pulled into the proteasome as easily, and the knots may make it harder for the protein to unfold, which is necessary for degrad...

Researchers wake up viruses inside tumors to image and then destroy cancers

... both surprised and lucky," he says. "Velcade is a proteasome inhibitor, but it also induces the lytic cycle thereby activating the TK in the Epstein-Barr virus. Once the TK is activated, we can image the tumors." To test their findings, the researchers used mice carrying human Burkitt's lymphoma, a cancer ...

Proteasome activator enhances survival of Huntington's disease neuronal model cells

...such protein build up in the cell is the ubiquitin proteasome system (UPS). In Huntington's disease (HD) brains...al proteins in HD. We first genetically engineered proteasome activators involved in either non-ubiquitinated protein degradation pathways (PA28ƒ×) or subunits of...

Penn researchers link cell's protein recycling systems

...aylor and his group study fruit flies in which the proteasome is disabled by a genetic mutation, which results i...w that this system can compensate for the impaired proteasome function, which in itself tells us that the two pathways intersect,” says Taylor. “The question was,...

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(Date:8/19/2014)... Efforts must be made to decrease China,s increasing caesarean ... August) in BJOG: An International Journal of Obstetrics ... the highest caesarean delivery rates in the world. Of ... by caesarean. Although the exact rate is not known, ... China reports total caesarean rates ranging from 36% to ...
(Date:8/19/2014)... used in supermarkets to encourage healthier spending habits? A ... that very question by tracking the purchasing records in ... to rate the nutritional value of foods for sale. ... David Just, PhD, and Brian Wansink PhD, author of ... over 150 Hannaford Supermarkets in the Northeastern United States ...
(Date:8/19/2014)... and Network-Level Science, , Imagine if we had the ... was responding to global changes in real time. Such ... multiple decades of information about ecological responses to environmental ... of different ecosystem types. , In fact, this ... Network, which will soon celebrate its 35th anniversary. , ...
Breaking Biology News(10 mins):Is China's 50 percent cesarean section delivery rate too high? 2Is China's 50 percent cesarean section delivery rate too high? 3This week from AGU: Long-term ecological research, predicting cholera outbreaks 2
(Date:8/20/2014)... HealthDay Reporter WEDNESDAY, Aug. 20, 2014 (HealthDay ... condition that causes a life-threatening irregular heartbeat, a new study ... lower risk of developing atrial fibrillation, compared to women who ... of the Journal of the American Heart Association . ... disorder even if they were obese, the study found. Obesity ...
(Date:8/20/2014)... Doheny HealthDay Reporter WEDNESDAY, ... mastectomy has long been an option, but a new study ... "The most common reasons women didn,t undergo reconstruction was ... more surgery or they were focused on their cancer treatment," ... at Memorial Sloan Kettering Cancer Center, in New York City. ...
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(Date:8/20/2014)... PITTSBURGH, Aug. 20, 2014 A common approach to ... blood did not improve survival chances for people who ... experts at the University of Pittsburgh School of Medicine. ... PLOS One , suggest acute hemodialysis, an aggressive method ... failure, may not provide a definitive benefit to the ...
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Breaking Medicine News(10 mins):Health News:Exercise May Guard Against Irregular Heartbeat in Older Women 2Health News:Exercise May Guard Against Irregular Heartbeat in Older Women 3Health News:Many Women Who Have Mastectomy Don't Get Breast Reconstruction: Study 2Health News:Many Women Who Have Mastectomy Don't Get Breast Reconstruction: Study 3Health News:Dallas-based Park Cities Pet Sitter Announces Participation in the 2014 National Association of Professional Pet Sitters “Presents 4 Pets” Program 2Health News:Dallas-based Park Cities Pet Sitter Announces Participation in the 2014 National Association of Professional Pet Sitters “Presents 4 Pets” Program 3Health News:Dallas-based Park Cities Pet Sitter Announces Participation in the 2014 National Association of Professional Pet Sitters “Presents 4 Pets” Program 4Health News:Pitt analysis questions use of acute hemodialysis treatment 2Health News:With 3943.8% Growth, Connexion Point, a Leader in Contact Centers for Health Care, Ranks 86th on the Inc. 500 List as One of the Nation’s Fastest Growing Companies 2
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