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Tag: "proteasome" at biology news

Compound from marine bacteria shows potential as multiple myeloma therapy

...r cells' proteasomes from working effectively. The proteasome work as a cell's "garbage disposal," chewing up and disposing of old, unwanted proteins. With their proteasome jammed, cells die from the backup of damaged proteins. "Proteasome inhibition is a key therapeutic ...

MIT research holds promise for Huntington's treatment

...mpound also had a strong protective effect against proteasome disruption, thus blocking one of the toxic effects of the huntingtin protein. The B2 compound also promoted large inclusions and showed a protective effect in a cellular model of Parkinson's disease, another neurodegenerative disorder caused by misf...

Johns Hopkins lab scientists tame overactive CF protein

... latches onto the damaged CFTR and sends it to the proteasome for destruction," Zeitlin says. "Using RNA interfe...by the use of RNA interference was superior to the proteasome inhibitor, researchers found. Both the drug and RNA interference also staved off inflammation cause...

Brain enzyme treatment relieves memory lapse in Alzheimer's mice

...th Alzheimer's after death found evidence that the proteasome remained intact but largely unable to degrade prot... cascade that results in the partial inhibition of proteasome activity more rapidly than is likely as the result of the accumulation of misfolded or undigestable ...

Study reveals how cells destroy faulty proteins in cystic fibrosis

...asome. This trash system is known as the ubiquitin proteasome pathway. "We've identified the trash collectors that recognize misfolded proteins, decide if they might be toxic to the cell and mark them with ubiquitin. The ubiquitinated proteins, including faulty CFTR, are then degraded or shredded by the pro...

MIT finds most complex protein knot ever seen

...rolase may prevent it from getting sucked into the proteasome as it works, Mirny said. The researchers hypothesi...oteins with complex knots can't be pulled into the proteasome as easily, and the knots may make it harder for the protein to unfold, which is necessary for degrad...

Researchers wake up viruses inside tumors to image and then destroy cancers

... both surprised and lucky," he says. "Velcade is a proteasome inhibitor, but it also induces the lytic cycle thereby activating the TK in the Epstein-Barr virus. Once the TK is activated, we can image the tumors." To test their findings, the researchers used mice carrying human Burkitt's lymphoma, a cancer ...

Proteasome activator enhances survival of Huntington's disease neuronal model cells

...such protein build up in the cell is the ubiquitin proteasome system (UPS). In Huntington's disease (HD) brains...al proteins in HD. We first genetically engineered proteasome activators involved in either non-ubiquitinated protein degradation pathways (PA28ƒ×) or subunits of...

Penn researchers link cell's protein recycling systems

...aylor and his group study fruit flies in which the proteasome is disabled by a genetic mutation, which results i...w that this system can compensate for the impaired proteasome function, which in itself tells us that the two pathways intersect,” says Taylor. “The question was,...

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