Strongest proof yet found for prion hypothesis
...isease. This controversial "prion hypothesis" was proposed by Stanley Prusiner in 1982, and led to Prusiner receiving the Nobel Prize in Medicine in 1997. Until now, however, scientists have been unable to confirm its validity by causing a TSE in normal lab animals by infecting them with malformed proteins (...Chemists identify immune system mechanism for methamphetamine binges
...according to the researcher. "If the mechanism we proposed proves true in humans, then it will help explain why addicts go on prolonged binges, requiring more frequent intake and ever-increasing amounts of the drug in order to achieve a high," says Janda, who led the study with his former student, Tobin Dick...Drug-resistant bacteria on poultry products differ by brand
...omised. In 2000, the Food and Drug Administration proposed to withdraw approval of fluoroquinolone drugs for use in poultry production. That effort has since been stalled by legal objections from Bayer, one of the pharmaceutical companies manufacturing the drug. In the meantime, two major U.S. poultry produc...Family trees of ancient bacteria reveal evolutionary moves
...iologist at Washington University in St. Louis has proposed that evolution is the primary driving force in the early Earth's development rather than physical processes, such as plate tectonics. Carrine Blank, Ph.D., Washington University assistant professor of geomicrobiology in the Department of Earth &...An entropy-based gene selection method for cancer classification using microarray data
...gulatory pathways. Here an entropy-based method is proposed that selects genes related to the different cancer classes while at the same time reducing the redundancy among the genes. Results The present study identifies a subset of features by maximizing the relevance and minimizing the redundancy of the se...UCSD researchers maintain stem cells without contaminated animal feeder layers
...e if contamination occurs from this source. For a proposed animal-free medium, the UCSD study takes advantage of a previously unidentified soluble factor this is secreted from mouse feeder layers to maintain stem cells' undifferentiated state and pluripotency, the ability to become all tissue types in the bo...Signaling protein builds bigger, better bones in mice
...ntal ovarian cancer test at issue, which was first proposed in 2002 by researchers in the journal, Lancet. That study reported dramatic results using mass spectrometry to search for a pattern of proteins in blood. In several sets of blinded samples, the test detected all patients who had ovarian cancer and on...Cracking the olfactory code in bees
...ntal ovarian cancer test at issue, which was first proposed in 2002 by researchers in the journal, Lancet. That study reported dramatic results using mass spectrometry to search for a pattern of proteins in blood. In several sets of blinded samples, the test detected all patients who had ovarian cancer and on......ntal ovarian cancer test at issue, which was first proposed in 2002 by researchers in the journal, Lancet. That study reported dramatic results using mass spectrometry to search for a pattern of proteins in blood. In several sets of blinded samples, the test detected all patients who had ovarian cancer and on...Another Look Finds Promising Proteomics Test is Not Biologically Plausible
...ntal ovarian cancer test at issue, which was first proposed in 2002 by researchers in the journal, Lancet. That study reported dramatic results using mass spectrometry to search for a pattern of proteins in blood. In several sets of blinded samples, the test detected all patients who had ovarian cancer and on......ongevity of actual living tubeworms. To date, the proposed return of sulfate to the sediments through the roots is only a hypothesis--albeit one with much to support it--that still awaits direct confirmation. By providing a model in which this hypothetical interaction provides real benefits and explains real...