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Tag: "proper" at biology news

New pathways for autoimmune treatment identified

...ary epithelial cells in the thymus are critical to proper i NKT cell development. A defective Aire gene disrupts this natural nurturing relationship by disrupting medullary epithelial cell function, leading to insufficient numbers of i NKT cells. "Whether or not you develop autoimmune disease to a large ...

Carnegie Mellon researchers discover new cell properties

... in HGPS patients may be unable to communicate the proper biological signals to the DNA inside the nucleus to help the cell grow, which contributes to the disease. Islam, an assistant professor of chemical engineering and materials science and engineering, says that the increased stiffness of the lamina ma...

A catalogue of proteins

...e marker-proteins could now also be assigned their proper place in the inventory. This method, called protein correlation profiling, was developed by Matthias Mann and his colleagues, and has previously been successfully used to determine the composition of single cell-organelle protein. After the individu...

Newly identified protein complex sheds light on axon growth mechanism

... characterised a new protein, UNC-69, required for proper locomotion . They show that UNC-69 interacts with UNC-76 in a protein complex likely to be involved in the trafficking of vesicles along axons - a process that drives axon growth and helps synapse formation. The research also shows that UNC-69 is dir...

Key stress protein linked to toxicities responsible for Parkinson's, Alzheimer's

...e (PDI), a chaperone protein that is necessary for proper protein folding in times of cellular stress. Published in today's issue of Nature, these findings revealed that in patients with Alzheimer's and Parkinson's Disease, overproduction of free radicals, specifically nitric oxide (NO), causes inhibition ...

New lab technique churns out fungus' potential cancer fighter

..., scientists can obtain enough rasfonin to conduct proper biological tests on it. "At a guess, I'd say that rasfonin itself will not be the final compound that might come to market," says Boeckman. "But we need to figure out how it works, how it triggers the cancer cell to shut itself down. The key is to f...

New lab technique churns out fungus' potential cancer fighter

..., scientists can obtain enough rasfonin to conduct proper biological tests on it. "At a guess, I'd say that rasfonin itself will not be the final compound that might come to market," says Boeckman. "But we need to figure out how it works, how it triggers the cancer cell to shut itself down. The key is to f...

Matrilin-3 gene discovered to prevent onset of osteoarthritis

...n unexpected property of matrilin-3 in maintaining proper BMD, a factor that was not previously examined," the authors write. "However, the mechanism of the association between increased bone density and joint degeneration is not known. Our data show that matrilin-3 deficiency results in both the increase o...

DOE JGI finishes 100th microbial genome

...nd a multitude of other amazing tasks and with the proper technology we can harness these capabilities." DOE JGI, a national user facility, has sequenced or is in the process of sequencing over 380 organisms, more than any other institution in the world. DOE JGI averages over 3.1 billion bases or letters ...

Septum keeps neurons in synch, can reduce epileptic seizures by 90 percent

...epileptic episodes when the brain did not have the proper theta rhythm. The researchers also found that when the theta rhythm was induced in the rats, it reduced epileptic discharges 86-97 percent. (The researchers induced theta in one of three ways ?by regulating the rats' anesthesia, by stimulating the s...

Spinal cord bridge bypasses injury to restore mobility

... fact, regenerate for long distances and establish proper functional connections. Silver said if the method is perfected and successful with primates, it could go to human trials within a relatively short time. His next step is a neural bridge that would help quadriplegics, who are unable to breathe...

FSU biologists uncover mechanisms that shape cells for better or worse

...ymmetric shape or composition critical to a cell's proper functioning. Their findings in fruit fly eggs may help to clarify how muscular dystrophy and some cancers develop in humans. That's because many of the genes involved in the cell-to-cell communication that triggers the development of cell polarity ...

Study reveals how cells destroy faulty proteins in cystic fibrosis

...dation system allows some proteins to regain their proper shape, offering a new avenue for treatments aimed ...ease the fitness of misshaped CFTR and get it into proper shape. Thus, "If we can figure out how to get CFTR into the right shape, we can cure the disease," C...

Successful transplantation from pig embryos to mice

...lanting tissues from pig embryos into mice lacking proper immune systems, they determined that the best time frame for pancreatic tissue was about a third of the way through gestation (from 42 to 56 days). In the new study, Reisner's team wanted to see if such tissues could function in the body. They first...

Structure determined for p53 tumor suppressor protein as bound to DNA for anti-cancer activity

...oteins of the dimer is likely as important for the proper functioning of the tetramer as its interface with ... within the dimer, the two cores have to be in the proper orientation to bind DNA. "So we decided that we needed to somehow lock the protein into a conforma...

Researchers find cause of frontotemporal dementia

... result is very surprising. Although progranulin's proper role in the brain is not yet known, it may well be responsible for the survival of brain cells, because FTD patients have a shortage of this growth factor. The new finding predicts that progranulin might also play a role in other types of brain disea...

Bedsores and bald hides: Novel roles revealed for a 'scaffolding' protein

...unds may lead to improved strategies for fostering proper healing with minimal scarring." K17's role in maintaining hair follicle strength is probably centered on its capacity to control the timing of follicle cell death during normal hair growth cycles, says Coulombe. The team previously reported that m...

New roles for growth factors: Enticing nerve cells to muscles

...ure that the developing nervous system establishes proper neuronal connections." Understanding how axons f...phy, and post-polio syndrome. Failure to establish proper connectivity in the brain may also underlie autism spectrum disorders and mental retardation. The m...

Pathway toward gene silencing described in plants

... one of the four chemical subunits of DNA. Without proper DNA methylation, higher organisms from plants to humans have a host of developmental problems, from dwarfing in plants to certain tumors in humans, and death in mice. One role of DNA methylation is to turn off repetitive genes, such as transposable e...

Salk and Stanford teams join forces to reveal two paths of neurodegeneration

... therapies that preserve injured axons and restore proper connections. Other researchers who contributed to this paper included postdoctoral fellow Oren Schuldiner, Ph.D., at Stanford and Ryan Watts, Ph.D., formerly a Ph.D. student in Luo's lab and now a scientist at Genentech. ...

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