MSKCC researchers uncover structure of key protein complex in cells
...ion both to and from the nucleus, and are vital to proper cell function. "The next step in this research is to probe the importance of the contacts observed in our structure with the biochemical activities and effects on the cell itself of disrupting these contacts," Dr. Lima said. He and his colleagues ar...Optimizing cell therapy against tumors is a balancing ACT
...es faced is selecting the appropriate T cells with proper antigen specificity. In a new study appearing in the June 1 print issue of The Journal of Clinical Investigation, Nicholas Restifo and colleagues identified which cells are optimal for treating large, vascularized, established tumors. The authors us...Tiny roundworm's telomeres help scientists to tease apart different types of aging
...er half of aging is the insulin signaling pathway, proper mitochondrial function and dietary restriction," h...erated aging in an organism, you need to have both proper telomere maintenance and those other genetic pathways intact," says Dillin. "If you wanted to develo...Scientists unpick genetics of first 15 minutes of life
...s a s�same mutant, which they know does not form a proper male pro-nucleus. By highlighting the chromatin and watching the changes it goes through at different stages of the fertilisation process, the scientists found that the pro-nucleus in s�same mutant is wound into a tight ball that could not interact ...Studies on human genome variation provide insight into disease
... repetitive sequences that flank genes crucial for proper development of the heart, face, and upper thorax. Dr. Bernice Morrow and her colleagues describe in this month's issue of Genome Research how they examined these flanking repetitive sequences for patterns of polymorphisms. "Our results show that ...Housecat-sized Siberian tiger cubs get collared
... repetitive sequences that flank genes crucial for proper development of the heart, face, and upper thorax. Dr. Bernice Morrow and her colleagues describe in this month's issue of Genome Research how they examined these flanking repetitive sequences for patterns of polymorphisms. "Our results show that ...PLoS Medicine publishes first trial of effect of male circumcision on HIV infection
...y medical personnel or traditional healers without proper training. Moreover, immediately after circumcision, men may be at a higher risk of acquiring infections (which is why the participants were asked to not to have sex for six weeks after the operation). A further concern is that circumcised men, consid...Researchers learn how blood vessel cells cope with their pressure-packed job
...mechanical and biochemical stimuli to regulate the proper orientation of these stress fibers," said Kaunas. "Indeed, we found that the stress fibers oriented in such a way to control their level of stress ?not too little and not too much." Chien and Kaunas collaborated with UCSD research scientist Shunichi...Anti-cancer Compound In Beer Gaining Interest
...menopausal "hot flashes" and osteoporosis - but no proper clinical trials have been done to study this. Information about these compounds appears to be spreading. Hop-containing herbal preparations are already being marketed for breast enlargement in women, the OSU research report said, without waiting for...Scientists discover the molecular switch for nerve cells' insulating jelly rolls
...an their unmyelinated cousins and are critical for proper neurological function. However, it wasn't known what actually initiated myelin production. The neuregulin gene encodes a growth protein made by neurons. Last year a group of German scientists discovered that it was implicated in determining the thi...Anti-cancer drugs may hold promise for premature aging disorder
...eshed other scaffolding proteins, preventing their proper integration into the lamina. If progerin's tendency to stick to the inner nuclear membrane is indeed the culprit in nuclear blebbing and the root of the progeria defect, Capell and his colleagues reasoned that they could prevent these defects by bloc...Science's Breakthrough of the Year: Watching evolution in action
...theory of biology since Darwin gave the theory its proper scientific debut in 1859. But Darwin probably never dreamed that researchers in 2005 would still be uncovering new details about the nuts and bolts of his theory -- how does evolution actually work in the world of influenza genes and chimpanzee genes...Common viruses may cause cancer
..., the resulting aneuploid cells no longer have the proper genetic makeup and frequently die. But researchers now know that tumor cells are often aneuploid--and very much alive. Whether aneuploidy is a cause or a consequence of a cancerous cellular state is the crux of a current debate. In a recent study, D...New study identifies key gene in development of connections between brain and spinal cord
...esearchers to determine that Fezl is necessary for proper development of neural connections to the spinal cord. "Normally, Fezl is required for certain brain cells to grow along the pathway that leads into the spinal cord. In the mice lacking the gene for Fezl, this pattern of spinal cord development wa...RNA splicing occurs in nerve-cell dendrites
...ifetime. However, failure in protein regulation or proper expression in neurons may give rise to cognitive dysfunction. "Most neurodegenerative and psychiatric illnesses exhibit dendrite dysfunction, therefore, the inability to properly generate spliced RNAs in dendrites or proteins may underlie aspects of ...Sooner is better with cochlear implants, Stanford scientist shows
... being heard as "ta." It is impossible to hear the proper sound while viewing the speaker's lips, noted Knudsen. Knudsen and Fox wondered if children born deaf would experience the McGurk effect after receiving cochlear implants. Funded by the National Institute on Deafness and Other Communication Disorder...HIV/AIDS rates in Tijuana, Mexico increasing at alarming rate
...s federal HIV/AIDS agency. "Simple steps, such as proper use of condoms and increasing the availability of sterile syringes, can make a major difference in fighting this epidemic," said Steffanie Strathdee, Ph.D., Chief of the Division of International Health and Cross-Cultural Medicine at UCSD, where the ...Infants can organise visual information at just four months
...h, Dr Farran argues, is essential to providing a proper starting point for the new research. "In many atypical disorders, people look at what's happening in adults and assume that the same patterns of performance would be observed in children", says Dr Farran. "But often there are quite different patterns...Neurons find their place in the developing nervous system with the help of a sticky molecule
...hat normally make this protein from assuming their proper position, resulting in brain malformation, researchers report in the April 26th issue of the Journal of Neuroscience. As Dennis D. M. O'Leary, Ph.D., senior author of the study and a Professor in the Molecular Neurobiology Laboratory put it, "prope...Pitt professor's theory of evolution gets boost from cell research
...ins act as chaperones, bringing molecules to their proper locations in the cell, and so on. In short, with that kind of protection from change, it is very difficult for mutations, of whatever kind, to gain a foothold. But extreme stress pushes cells beyond their capacity to produce protective proteins, and ...