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Tag: "proof" at biology news

Targeted drug delivery achieved with nanoparticle-aptamer bioconjugates

...l years. Using prostate cancer as a model disease, proof of concept nanoscale targeted drug delivery vehicles were developed (1 nanometer = 0.000000001 meter), which can target prostate cancer cells with high specificity and efficiency. Once bound to prostate cancer cells, the nanoparticle/aptamer bioconju...

Researchers use 'trickery' to create immune response against melanoma

...l years. Using prostate cancer as a model disease, proof of concept nanoscale targeted drug delivery vehicles were developed (1 nanometer = 0.000000001 meter), which can target prostate cancer cells with high specificity and efficiency. Once bound to prostate cancer cells, the nanoparticle/aptamer bioconju...

Alleged 40,000-year-old human footprints in Mexico much, much older than thought

...in England touted these "footprints" as definitive proof that humans were in the Americas much earlier than 11,000 years ago, which is the accepted date for the arrival of humans across a northern land-bridge from Asia. These scientists, led by geologist Silvia Gonzalez of Liverpool's John Moores Universi...

Study ties 'new' cell-death mechanism to developmental and degenerative brain disorders

...e involved in human neurodegenerative disease, but proof has been lacking," Pulst said. "This is the first time neurodegeneration has been directly linked to potassium channel mutations." In the Nature Genetics article, the researchers describe their analysis of two ataxia-causing mutations of the KCNC3 ...

Ocean virus identified in human blood samples

...questions. Further research is needed to establish proof that infection with this virus in humans is causing liver damage or some other problems, which may include encephalitis and spontaneous abortion. The viral group being studied is the genus Vesivirus, one of four genera in the Caliciviridae viral fam...

Natural selection at single gene demonstrated

Biologists seeking elusive proof of natural selection at the single-gene level have...e-organism level, researchers consider biochemical proof of selection "the Holy Grail" of population genetics. "What has proven very difficult is to connect...

Hooked on fishing, and we're heading for the bottom, says scientist

... in the world's fisheries is less about scientific proof than about attitude and political will. And, he says, the world's fish need a dynamic, high-profile political champion like a Bono or Mandela to give finned creatures the public profile of cute and furry ones. "It's time for leadership on global f...

Scientists design potent anthrax toxin inhibitor

...Dr. Kane says the recent experiments demonstrate a proof of principle and suggest that polyvalent inhibitors could be used along with antibiotics in a clinical setting. Aside from its inherent toxicity, anthrax toxin also accelerates the disease process. Thus, combining antibiotics with a toxin inhibitor m...

Heart-healthy compound in chocolate identified

...ersity. "The results of this study provide direct proof that epicatechin is, at least in part, responsible for the beneficial vascular effects that are observed after the consumption of certain flavanol-rich cocoas," Schroeter said. Key to the study were volunteers from the Kuna Indians, who live on the ...

New compound stops brain cell degeneration in Alzheimer's disease

...generative diseases in general because it provides proof of concept that targeting over-production of cytokines by activated glia is a viable approach that has the potential to modulate disease onset and progression, the researchers said. Decline of cognitive functions linked to the part of the brain call...

UCI researchers discover key factor for survival of human embryonic stem cells

...cording to Donovan, the studies also offer further proof that new stem cell lines need to develop beyond those already in existence. Federally approved hES lines currently used for research were not created in the presence of growth factors such as neurotrophins. The work undertaken by Donovan and Lock ind...

Study in Science holds promise for a new approach to drug therapy

...potential. Researchers tested two compounds as a proof of general principle, M119 and M201, which bound most effectively to the hotspot. For the purposes of the experiment, researchers chose to test the affect of M119 and M201 on two biological systems that the G protein gamma-beta subunit controls. In o...

Researchers unravel DNA tangles and enzyme seamstresses

...stress their results represent only a quantitative proof of concept, they do see the finding as particularly relevant for understanding diseases such as cancer, where cell multiplication goes haywire. "Besides further elucidating the principles we found, what needs to be done now is to test these findings ...

Climate change drives widespread amphibian extinctions

Results of a new study provide the first clear proof that global warming is causing outbreaks of an infectious disease that is wiping out entire frog populations and driving many species to extinction. Published in the Jan. 12 issue of the journal Nature, the study reveals how the warming may alter th...

Rewind, please: Nature paper shows that cell division is reversible

...onditions. "Dr. Gorbsky's results provide elegant proof that the cell cycle must be precisely controlled," said Dr. Rodger McEver, OMRF vice president of research. "Now he and his lab can work toward developing innovative methods to probe and better understand the complex process of cell division." Gorb...

First human trial of antibacterial contact lens

...ch have tested antibiofilm compounds and generated proof of concept data in a broad range of product categories in the medical, industrial and consumer fields. ...

Mitochondrial DNA sequencing tool updated

...iations than the first-generation chip. As a proof of principle, the Mitochip v2.0 also detected 31 variations in the non-coding D-loop of 14 head and neck tumor samples. Included in this tally were several mutations that possibly are informative of the disease. "The real interesting thin...

First study to show how immune cells 'speak' to each other in vivo

... observed prior to this research. Although formal proof of this awaits the development of drugs or mutations that interfere selectively with synapse formation, the confirmation of these cellular structures increases the understanding of the immune system and paves the way for further research on the body'...

UF scientists restore sight to chickens with blinding disease

...hat restored vision to blind Briard dogs. "This is proof of concept using a unique vector, animal model and approach. One would hope this could happen in a human." Semple-Rowland, a College of Medicine faculty member, has worked since 1986 to first discover the malfunctioning gene, known as GC1, and then ...

Elephants, large mammals recover from poaching in Africa's oldest national park

... "The results of the census are encouraging, and proof that protecting the park's wildlife can be done in the most turbulent conditions," said WCS researcher Deo Kujirakwinja. "Poaching is still taking a toll on wildlife and the rate of recovery is being slowed as a result, but it is clear that the effor...

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