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Tag: "proof" at biology news

Bacterial genome sheds light on synthesizing cancer-fighting compounds

...des in the lab, the team demonstrated an important proof of principle for the biosynthesis of naturally occurring marine products." ...

Combination therapy leads to partial recovery from spinal cord injury in rats

...ally that it works," says Dr. Whittemore. "It is a proof of principle." Although the finding is promising, much work remains before such a technique could be used in humans. The study appears in the July 27, 2005, issue of the Journal of Neuroscience.[1] In the study, the researchers took cells called spe...

Bioinformatics reveals new gene regulation system

...rch and training center of bioinformatics. "It's a proof of principle that you can go a very long way by comparative genomics now." Their findings will be published in the July issue of Trends in Genetics, with early publication now online. Gelfand is presenting the work on June 24, 2005, at the annual mee...

Researchers find first evidence of venom system in extinct mammal

... the fossil to Scott, who thought it was the first proof of a venomous capacity in an extinct mammal, but he took it to Fox to confirm his notion. Fox and Scott had found individual canine fossils with similar grooves, but they didn't know which species of animal the loose fossils came from. The Bisonvale...

Major advance made on DNA structure

...ot distort its structure. "Essentially, this is a proof of concept, a demonstration that this approach to studying DNA structure will work, and can ultimately be used to help understand biology," Ho said. For instance, one of the unusual DNA structures called a Holliday junction, whose structure was co-s...

Siberian tigers hang tough

...spot in the conservation of tigers in Asia, and is proof of our belief that a few dedicated individuals, with sufficient motivation and adequate support, can make a difference in the world." Coordinators of the survey effort gathered in Vladivostok today to present their results, but emphasize that number...

Pinpointing a culprit molecule in Alzheimer's disease

...t in the July 21, 2005, issue of Neuron definitive proof that Ab42 is, indeed, the culprit molecule. In their experiments, they created transgenic mice that overproduced either Ab40 or Ab42 in the absence of overproduction of APP. Thus, they could precisely study the role of each of these molecules in AD p...

Sleeping beauty plays a significant role in identifying cancer genes

...n humans. But as Largaespada pointed out, "We have proof of principle that we're on the right track. We know that some of the same genes that are mutated in cancer in mice using Sleeping Beauty are also mutated in the same form of cancer in humans. An example is the Notch1 gene, which was mutated in 50 per...

Targeting a key enzyme with gene therapy reversed course of Alzheimer's disease in mouse models

...of Alzheimer's disease. "What we are showing is a proof of principle that stopping the synthesis of a protein that is necessary for the formation of the telltale plaques reverses the progression of the disease, and more importantly, the cognitive function of these mice, which had already been impaired, ha...

Drug resistant avian influenza viruses more common in Southeast Asia than North America

...ndomly throughout the world. But we now have solid proof that in Southeast Asia, and especially in China, these mutations are undergoing strong selective pressure." Selective pressure refers to the extent to which an organism has acquired either a beneficial genetic trait that gives it a survival advantag...

Bone marrow stem cells may heal hearts even years after heart attacks

...d only 18 patients, it does not provide conclusive proof that the technique is effective. However, he noted that the results of large randomized, double-blinded clinical trials are expected soon. ...

Gene therapy works in mice to prevent blindness that strikes boys

...h Foundation supported the research. "We now have proof of principle that gene therapy can basically prevent retinoschisis," said Stephen Rose, Ph.D., chief research officer for the Maryland-based Foundation Fighting Blindness. "Furthermore, this therapy apparently demonstrates that even if disease has be...

Biotechnology's newest chemical tool

... carbon chains as long as 4 to 5 units, we provide proof of principle that further extensions should also be tolerated," Klimasauskas said. Due to their sequence-specific nature, the scientists found that methyltransferases have a distinct advantage over other commonly used labeling techniques for DNA an...

The earliest animals had human-like genes

...y been speculations that this may not be true, but proof was missing. Now we have direct evidence that genes were already quite complex in the first animals, and many invertebrates have reduced part of this complexity." Not only are the introns there ?the team also discovered that their positions within g...

Restoring silenced suppressor gene kills lung-cancer cells

... another group showed no tumors. "Our study is a proof of principle," Huebner says. "It shows that if the WWOX gene can be delivered into tumor cells, it can kill them. "We also showed that if a silenced WWOX gene is present and can be turned back on, that too will kill tumor cells," adds first author ...

Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer

...ancer cell lines and in a mouse cell control. In a proof of concept study, they found evidence that the alternating LHRH and lytic peptide on the ironoxide particle was effective at killing cancer cells, suggesting that the cell-killing peptide worked best when it came in direct contact with the cell membr...

Federal grant funds research on novel HIV therapy

...ch is analogous to HIV. This study aims to provide proof of concept for human trials under Project 4. Project 4, led by Pablo Tebas, M.D., of the Department of Medicine at the University of Pennsylvania Medical School, will be a phase 1 (safety) trial of the NK-1R antagonist aprepitant (trade name Emend)...

Group proves it's possible to grow new lung alveoli by growing new blood vessels

...le who have emphysema. "At this stage it's simply proof of principle," says Dr. Thébaud, also a pediatrician at the Stollery Children's Hospital's Neonatal Intensive Care Unit. The next step is to prove it's possible to replicate safely in larger mammals. Once that's done, it's possible the concept--growi...

ASU researchers 'wire' DNA to identify mutations

...ring the current of a single DNA molecule. For a proof of concept of the potential for measuring SNPs, the group used DNA of 11 or 12 bases in length dissolved in a physiologically relevant saline solution. From one electrode tip, a small current, or bias is used to probe the internal electronic states...

Argonne researchers confirm lead in Beethoven's illness

... at age 57, there has been much speculation but no proof of the cause of his illnesses and death." Researchers performed the elemental X-ray fluorescence analysis at an Advanced Photon Source X-ray Operations and Research beamline. "The APS is the best machine in the country to perform the research in th...

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