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Tag: "promoting" at biology news

Source of molecular triggers in cutaneous T cell lymphoma identified

...eration may be useful for cancer immunotherapy and promoting Treg development may be useful to induce tolerance in autoimmune disease and transplantation," ...

Protein discovery could unlock the secret to better TB treatment

... the structure of a protein known as resuscitation promoting factor (Rpf). Five versions of the Rpf protein exist in TB bacteria. The paper's unveiling of the molecular structure of Rpf could be crucial to the treatment of TB in the future. Dr John Ward, Dept of Biochemistry and Molecular Biology at UCL, said...

Novel Enzyme Shows Potential As An Anti-HIV Target

...es just 14 proteins, which play different roles in promoting viral infection and virulence. As a retrovirus, HIV uses the host’s cellular machinery—including RNA polymerases, which carry out transcription—to copy its RNA genome into DNA and infiltrate human chromosomal DNA. Once the virus is integrated (now ca...

An HIV Protein Plays a Surprising Role in Gene Activation

...hat Tat may well stimulate assembly in addition to promoting transcription elongation. And it may be this resourcefulness that makes Tat such a potent activator—and HIV so hard to control. (For more on Tat's role in HIV transcription, see “Novel Enzyme Shows Potential as an Anti-HIV Target?[DOI: 10.1371/journa...

Mouse brain tumors mimic those in human genetic disorder

...ay involve agents that preventthe supply of growth promoting factors provided by new blood vesselsand microglia."Next, the researchers used the mouse model to investigate a clinicalconcern. Physicians rely on several tests to determine whether a childwith an optic pathway glioma should undergo treatment for th...

Enzyme shown to help protect genomic stability

... from histones. Sir2 has also been associated with promoting genomic stability, and some studies have linked it intriguingly to the aging process. Some studies, for example, have suggested that low-calorie diets that extend life also boost Sir2 activity dramatically. ...

Newly Discovered Compound Blocks Known Cancer-Causing Protein

... can cause it to become stuck in an "on" position, promoting uncontrolled cell growth. Mutations in Ras that permanently activate it have been found in half of all colon cancer and 90 percent of pancreatic cancers, among other cancers. Casey and his colleagues in Duke's Department of Pharmacology and Cancer B...

Rush Physicians Using Gene Therapy For Heart Patients With Moderate To Severe Chest Pains Who Do Not Benefit From Other Treatments

...turn stimulates the growth of new blood vessels by promoting the proliferation of endothelial cells in the heart. New blood vessels are required to provide oxygen-carrying blood to heart muscles to compensate for the blocked heart arteries. The subsequent, improved blood flow relieves the painful symptoms of ...

International HapMap consortium expands mapping effort

...as those protecting against infectious diseases or promoting longevity. "We are excited by the opportunity to apply our technology to all publicly available SNPs. This effort is so important that Perlegen is willing to contribute some of its own resources to make this possible," said Kelly A. Frazer, Ph.D., v...

Cricket's finicky mating behavior boosts biodiversity

...y refuse to mate with males of other species, thus promoting the formation of new species. The scientists say their findings shed light on the role of individual choices in the evolution of species and the growth of biodiversity. "Animals with nervous systems and brains have preferences and can make choices,...

Wisconsin researchers identify sleep gene

...es to treating sleep irregularities in humans-from promoting restorative sleep to prolonging wakefulness. "This research offers the possibility of developing a new class of compounds that could affect potassium channels in the brain rather than other brain chemical systems targeted currently," says lead autho...

Harmful chemicals may reprogram gene response to estrogen

...nce estrogen, a female hormone that is involved in promoting the growth of tumors by regulating the activity of key genes involved in cell growth. "We found that the DES treatment somehow 'reprogrammed' how these genes respond to estrogen, making them much more responsive to estrogen than normal," said Walker....

Protein That Promotes Survival Of Stem Cells Might Be Key To Poor Leukemia Prognosis

...such Bcl-2 family protein--Mcl-1--is essential for promoting the survival of these cells." Progenitor cells are precursors arising from HSCs; these cells produce daughter cells that become increasingly specialized and then produce specific types of blood cells, such as B lymphocytes--immune cells that produce...

Genetic defects give the immune system the green light to attack the pancreas

...ion of errant T-cells, and an increase of activity promoting their survival. The safeguard system was broken. The T-cells were alive and able to leave the thymus and attack beta cells. Now that the chromosomal regions are known, the researchers are seeking the precise genes involved. “Once these genes are ide...

New tumor-suppressor gene discovered

...owth by restricting the proliferation of cells and promoting their timely death," Lai says. This is the first ...o work together in reducing cell proliferation and promoting cell death, so the tissues get much smaller." Lai's lab also performed other experiments that demons...

Protein Discovery Could Unlock The Secret To Better TB Treatment

... the structure of a protein known as resuscitation promoting factor (Rpf). Five versions of the Rpf protein exist in TB bacteria. The paper's unveiling of the molecular structure of Rpf could be crucial to the treatment of TB in the future. Dr John Ward, Dept of Biochemistry and Molecular Biology at UCL, said...

Natural Killers Could Lead to New Hepatitis Treatments

...an obtain so far points to CXCR6 being involved in promoting survival of these NKT cells when they get into the environment of the liver, and that's how the cells tend to accumulate there,?said Littman. “Our data don't support a critical role of CXCR6 in crawling behavior of the cells.?/p> Evidence for the...

The first impact factor for PLoS Biology ?13.9

...rnal less than two years old, from a new publisher promoting a new business model that supports open access to the scientific and medical literature. An impact factor of 13.9 places PLoS Biology above such established journals as EMBO Journal, Current Biology, and the Proceedings of the National Academy of Sc...

Study of energy and health in Africa focuses spotlight on charcoal and forest management

...and the Harvard School of Public Health finds that promoting cleaner, more efficient technologies for producing charcoal in Africa can save millions of lives and have significant climate change and development benefits. The African continent, as well as many developing nations in Asia and Latin America, is de...

Combination therapy leads to partial recovery from spinal cord injury in rats

.... However, until now it has not been clear whether promoting new myelin growth in the spinal cord can reverse this damage, says Scott R. Whittemore, Ph.D., of the University of Louisville in Kentucky, who led the new study. "Many other investigators have suggested that remyelination is a possible approach to r...

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