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Tag: "promoter" at biology news

Genomatix technology facilitates de novo identification of new renal disease associated genes

... approaches allow rapid characterization of shared promoter structures which can be used to find novel interac...erular slit diaphragm. An evolutionarily conserved promoter model was generated. Genome-wide scans using this promoter model effectively predicted a previously ...

Gene first linked to rare disease may trigger skin cancer, other tumors

...e there, the protein binds and modifies the cancer promoter Bcl-3 to prevent its nuclear accumulation. In addition to elucidating the cause of cylindromas, the findings might have important implications for understanding the events underlying skin cancer, and perhaps also tumors in other body tissues, the re...

Basic work on E. coli identifies two new keys to regulation of bacterial gene expression

...eviously underappreciated sections of both the DNA promoter region and RNA polymerase, according to work done ... this case, regulation is achieved not because the promoter makes a special contact, but because it can't establish contact at all," says Gourse. "This is an ex...

MatBase -- A new transcription factor knowledge base released by Genomatix

...r MatInspector, the de facto gold standard in gene promoter analysis, used by more than 31.000 scientists around the globe today. More than 80% of our matrices match less than once in 1000 base pairs of random DNA sequences", she continues. MatInspector employs the weight matrix descriptions as contained in ...

How bad is malaria anemia? It may depend on your genes

...s in response to infection. One version of the MIF promoter leads to less MIF protein made, while cells containing another version of the MIF promoter make much more MIF protein. Differences in the MIF promoter also have been linked to the severity of...

Learning the language of DNA

...d the traditional view that each gene has a single promoter and a single starting position. The team found that, while genes that are only turned on in a specific tissue or at a specific point in time use the traditional model of a single start site, genes used in many tissues have a broad distribution of s...

Targeted virus compels cancer cells to eat themselves

... (short for human telomerase reverse transcriptase promoter regulated adenovirus) infected the glioma cells and induced autophagy by inactivating a molecular pathway -- the mammalian target of rapamycin (mTOR) pathway -- that is known to prevent cellular self-cannibalization. The result was a huge differ...

Scientists reveal structure of gateways to gene control

...studied as a model of how human cells work. These promoter nucleosomes are the only ones in the yeast DNA tha...s H2A.Z protein as a tool for separating all these promoter nucleosomes from the other parts of the yeast's DNA. Next, the team used a state-of-the-art DNA-seq...

Scientists map key landmarks in human genome

... regulates target genes, and specifically where in promoter regions of those genes does MITF bind," Fisher said. "In the process of this work, we asked whether MITF is binding between nucleosomes or on top of nucleosomes, and that led us to devise a method to ask where the nucleosomes are located." The res...

Inflammation may play role in metastasis of prostate cancer

...lso support the view that RANK ligand is a general promoter of prostate, and possibly breast, cancer metastasis. "Maspin is a very potent inhibitor of metastasis; in a patient with metastasis, cells have found a way to turn off Maspin, which may depend on invasion of the tumor with RANK ligand-producing cel...

Stability of mRNA/DNA and DNA/DNA duplexes modulates mRNA transcription

... impressive, given that several other factors like promoter effectiveness, promoter regulation, and mRNA half-life directly influence mRNA level, as well," says Stoynov. The researc...

Wheat can fatally starve insect predators

...duce useful nutrients for the insect. Instead, the promoter would be hooked up to a lectin or toxin gene and i...nteractions would enable the scientists to use the promoter tactic only in the vegetative parts of the wheat plant rather than in the head or grain portions. Th...

Gene variations contribute to aggression and anger in women

...hose who had one or both of two alterations in the promoter region of the serotonin receptor 2C gene were more likely to score lower on two common tests for anger, hostility and aggression. These findings may aid in establishing a potential marker for certain conditions associated with aggression and anger...

Effect on breast tumors of DNA alternations in 3 genes described

...cer promoters when exposed to a process called DNA promoter hypermethylation. Hypermethylation is a process t...ade or nuclear grade. "Our data suggested that promoter hypermethylation is common in breast cancer," Tao added. "Because promoter hypermethylation is poten...

Fat screen delivers plant-derived chemical with antidiabetic effects

...estore insulin sensitivity by activating a central promoter of fat tissue production called peroxisome proliferator-activated receptor ã (PPARã). "The current explanation for this paradoxical mode of action is the idea that the body needs a place to store lipids," Tontonoz said. "If the body becomes less a...

Gene therapy delivery of nerve growth factors reverses erectile dysfunction in animal model

...s nerve of rats. GDNF is an important nerve growth promoter and has been shown in other studies to contribute to survival and regeneration of penile nerves. Neurturin also is a nerve growth factor closely related to GDNF. Control mice received only the virus without the GDNF or neurterin genes inserted. F...

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