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Tag: "promoter" at biology news

Novel Enzyme Shows Potential As An Anti-HIV Target

...nzyme cyclin-dependent kinase 9 (CDK-9) to the HIV promoter (where transcription begins). CDK-9 chemically modifies the RNA polymerase and enhances its transcribing efficiency. The transcription process—including the labyrinthine protein–protein and protein–DNA (and in the case of Tat, protein–RNA) interacti...

An HIV Protein Plays a Surprising Role in Gene Activation

...n factors were “virtually undetectable?at the core promoter in the absence of Tat. Adding Tat recruited all the usual transcription factors to the promoter and increased transcription. But none of the TAFs that normally associate with TFIID were found. Whe...

Whole genome promoter mapping - Human Genome Project v2.0?

... to track critical proteins binding to each gene's promoter to identify 10,567 active promoters, 6 091 of which were previously unknown. LICR's Dr. Bing Ren, the senior author of the study and a faculty member at the UCSD School of Medicine, says that although scientists have found most of the protein-coding...

Bioinformatics reveals new gene regulation system

...erved that their signal always overlapped with the promoter signal, the region of DNA required for the initiat...k by allowing other proteins to bind on top of the promoter sequence and physically block promoters. Therefore, the duo predicted that the NrdR-box functioned a...

Gene therapy advance treats hemophilia in mouse models

...IV that expresses the therapeutic gene so that its promoter that causes gene expression worked only when it wa...ans of the body, it won't express well because its promoter is liver-specific," McCray said. "This modification helps prevent negative side effects. For example...

New bioinformatics technique for systematically analyzing key regions in DNA that help control gene activity

...te. "But you can identify their binding sites in a promoter or regulatory region - there are usually a few of these for each gene. We wanted to see if we could somehow deduce how many transcription factors at a time, or combinations of factors, are coming together physically and how these combinations regulat...

Change in gene may be underlying molecular defect in some colorectal cancers

...se (MGMT) is often methylated--that is, the gene's promoter region has methyl groups added to it, which inacti... in Houston, and colleagues hypothesized that MGMT promoter methylation could be one of the characteristics of the field defect in colorectal cancer, so they st...

Genomatix, AAAS ink agreement

...etabolic pathways, transcription factor knowledge, promoter sequence analysis, different Gene Ontology and MESH filters -- all in one dynamically overlayable package -- makes BiblioSpherePE even more powerful and essential for molecular biology research." ...

Suppressing growth hormone in early adulthood may prevent cancer

...enter. IGF-1 in the blood also may act as a tumor promoter during the early development of cancer, he said. Although additional research is needed, he said, drugs in the somatostatin class are currently available to suppress growth hormone and IGF-1 in people, so somatostatin analogs could be given as preve...

Hepatitis C complicated by morphine withdrawal

...observations. MW and PW inactivated the IFN-alpha promoter (the switch for making IFN-alpha) by directly inhibiting its activator, interferon regulatory factor-7 (IRF-7), and this effect was more pronounced in HCV replicon-containing cells. Finally, the ability of IFN-alpha treatment to block HCV replicon e...

Gene therapy reverses genetic mutation responsible for heart failure in muscular dystrophy

...o block it. In addition, we used a muscle-specific promoter in the virus, which also should lower the risk of any potential immune response against the gene product. In fact, in hamsters, we did not find any immune response to the human delta-sarcoglycan protein that was encoded by the AAV vector under the co...

Embryonic stem cells accrue genetic changes

...s case methyl groups on a gene region known as the promoter -- help control whether a gene is used by a cell to make proteins. The researchers determined the methylation status of 14 genes in each of the batches of stem cells; three of the genes did show different methylation patterns in late batches compared...

Scientists pinpoint inflammation gene

...riant in the SEPS1 gene a variation in the gene's promoter region, which regulates SEPS1 expression as the most important factor among the individuals with the highest levels of inflammation. This allowed an Australian research team at Deakin University led by ChemGenex Pharmaceuticals to conduct laborato...

Synthetic Protein Eases Arthritis Symptoms in Mice

...is, who suffer from excessive inflammation. A key promoter of inflammation is a chemical called tumor necrosis factor alpha (TNF-alpha). TNF-alpha starts a chemical chain reaction leading to inflammation by binding to two cell surface receptors, TNFR-1 and TNFR-2. Naturally occurring PLAD helps both forms of...

'Perception' gene tracked humanity's evolution, scientists say

... humans and chimps. It's the prodynorphin gene's promoter sequence -- upstream DNA that controls how much of...nd that high genetic variation in the prodynorphin promoter was unique to humans. Other primates' promoters were far more homogeneous. Exactly how prodynorphi...

Key brain regulatory gene shows evolution in humans

...rchers analyzed the sequence structure of the PDYN promoter segment in humans and in seven species of non-human primates -- chimpanzees, bonobos, gorillas, orangutans, baboons, pig-tailed macaques and rhesus monkeys. They found significant mutational changes in the regulatory sequence leading to humans that i...

Researchers discover a new genetic cause of Alzheimer's disease

...g the amount of each protein that is produced. The promoter of a gene has the most important control function ...), the researchers found genetic variations in the promoter that increased the gene expression and thus the formation of the amyloid precursor protein. These va...

The urban evolution lab

...g the amount of each protein that is produced. The promoter of a gene has the most important control function ...), the researchers found genetic variations in the promoter that increased the gene expression and thus the formation of the amyloid precursor protein. These va...

Tool developed to silence genes in specific tissues using RNAi

... their study, the researchers made a vector with a promoter specific for nurse cells in the testis, so that the small RNA that is associated with WT1 is only made in this cell type, thereby reducing WT1 levels that are only in the nurse cells. Other organs, like kidney, that need WT1 to function are not affec...

Dying of excitement

...his mutation --- a single nucleotide change in the promoter region of the EAAT2 gene -- was equally prevalent ...te for the repressor GCF2 -- a swap that inhibited promoter activity in transfected rat brain cells. Whether the mutant promoter decreases EAAT2 expression in ...

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