Scientists determine structure of enzyme that disrupts bacterial virulence
...esearch Center at Brandeis University. "One of the promising aspects of potential therapies based on this enzyme is that it targets a different pathway than current antibiotics." The enzyme works by disrupting the ability of certain bacteria to sense their own population growth ?the key to triggering genes t...Seaweed yields new compounds with pharmaceutical potential
...cell death (called apoptosis), a mechanism that is promising for development of new anti-cancer drugs, researchers noted. The findings on three of these compounds ? called diterpene-benzoate natural products -- are reported in the Oct. 12 online issue of the American Chemical Society journal Organic Letters. ...Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer
...to Leuschner, the approach using nanoparticles has promising applications for both imaging and treatment at the same time, and might also be used to monitor treatment responses in breast cancer patients. The approach might be useful for other cancers, such as colon, lung, and ovarian, as well as for melanoma a...Machinery of the 'marijuana munchies'
...e blocking the cannabinoid receptor, CB1, offers a promising approach to treating obesity. One such compound, rimonabant (trade name Acomplia TM ) is already undergoing clinical testing. In an article in the December 22, 2005, issue of Neuron, Young-Hwan Jo and colleagues report how the circuitry of CB1 is in...Stroke treatment a step closer after trial
...or stroke has taken a major step forward following promising results from the first clinical trial. Researcher...st if IL-1ra is safe in stroke patients and showed promising results," said Professor Rothwell, a world-renowned neuroscientist based in the University's Faculty...Penn Surgeons Use Completely Robotic Surgery to Successfully Treat Prostate Cancer
... develop the disease during his lifetime. However, promising new treatment options have been developed to help combat this threatening disease. One of the most innovative of these treatments is robotic-assisted laparoscopic prostatectomy (removal of the prostate). The University of Pennsylvania Health System ...Scientists learn to predict protein-stabilizing ability of small molecules
... develop the disease during his lifetime. However, promising new treatment options have been developed to help combat this threatening disease. One of the most innovative of these treatments is robotic-assisted laparoscopic prostatectomy (removal of the prostate). The University of Pennsylvania Health System ...Gene therapy potential for treatment of pancreatic cancer
...duction of a protein called vasostatin may prove a promising new way of treating pancreatic cancer, suggests re...urs, including pancreatic cancer, and represents a promising therapeutic option for malignancy with a poor prognosis," conclude the authors. ...Jefferson researchers find nanoparticle shows promise in reducing radiation side effects
...duction of a protein called vasostatin may prove a promising new way of treating pancreatic cancer, suggests re...urs, including pancreatic cancer, and represents a promising therapeutic option for malignancy with a poor prognosis," conclude the authors. ...Sangamo BioSciences demonstrates its ZFP treatment protects cells from HIV infection
...llaborating with the Company further to bring this promising approach into the clinic." ......days after the stroke. Two factors make the study promising in the search for treatments for this deadly disease. First, shutting down the IKK2 signal had beneficial effects even when it was done a few hours after the stroke. That is important when thinking about possible human therapies; it usually takes tim...Engineered Stem Cells Show Promise For Sneaking Drugs Into The Brain
...ived neurotrophic factor (GDNF). In some small but promising clinical trials, GDNF showed a marked ability to provide relief from the debilitating symptoms of Parkinson's. But the drug, which is expensive and hard to obtain, had to be pumped directly into the brains of Parkinson's patients for it to work, as i...UCLA discovery will aid in treatment of patients with a deadly brain cancer
...rviving 253 days versus 50 days. To confirm their promising work, Mischel and his team obtained tissue samples from 33 brain cancer patients treated at another facility without knowing who the responders were. They were able to independently replicate their results, confirming that those with both genetic var...Infant transplant patients resist infections that kill adult AIDS patients
...'t suffer from infections as AIDS patients do. So promising is the work that it recently garnered a $6 million grant from the National Institutes of Health to support further research into the roles of T cells, B cells and antibody production in the outcomes of pediatric heart transplants. "We're very excited...Contagious obesity? Identifying the human adenoviruses that may make us fat
...'s a new and surprising piece of advice based on a promising area of obesity research: "Wash your hands." There is accumulating evidence that certain viruses may cause obesity, in essence making obesity contagious, according to Leah D. Whigham, the lead researcher in a new study, "Adipogenic potential of mult...Stem cells from muscles can repair cartilage
...y of therapeutic proteins to the injured site is a promising new approach to repairing articular cartilage. Pr...n. The authors conclude that skeletal muscle is a promising source of cells that can differentiate into cartilage-producing cells. "The MDSCs used here served a...Study shows AIDS drugs cost-effective, care underfunded
...indefinitely, Dr. Saag warned. Notwithstanding the promising findings on HAART's cost-effectiveness, "Providing drugs alone is not enough," he said. "We must focus now on creating appropriate incentives for providers to care for HIV patients. The current pool of providers is struggling to make ends meet. As th...Diabetes researchers pioneer islet cell xenotransplantation in primate studies
...keys, a procedure the researchers say represents a promising intermediate solution to the critical supply problem in clinical islet cell transplantation. "Our work at the U of A and Emory, along with recent work at the University of Minnesota, is very exciting and shows that xenotransplantation in humans may ...Carnegie Mellon develops non-invasive technique to detect transplant rejection at cellular level
...ntist Chien Ho and his colleagues have developed a promising tool that uses magnetic resonance imaging (MRI) to track immune cells as they infiltrate a transplanted heart in the early stages of organ rejection. This pre-clinical advance, described in an upcoming issue of the Proceedings of the National Academy...... immune system's response." That makes IKK a very promising target for new medications designed to boost or suppress the immune system, the researchers said. An overactive immune system, for example, can set off the excessive inflammation associated with rheumatoid arthritis and lupus. In addition, some cance...