proliferation 2 4

Tag: "proliferation" at biology news

Possible birthplace of malignant brain tumors identified

...of mature brain cells and launch into the abnormal proliferation pathway. Importantly, the researchers found that stopping the PDGF infusion caused a complete regression of the nodules. The researchers wrote that "these findings are significant due to our limited knowledge of surface markers for neural stem cell...

Gene first linked to rare disease may trigger skin cancer, other tumors

...d that the defect stemmed from an increase in cell proliferation rather than cell survival. Isolated CYLD-deficient skin cells, when treated with the tumor-inducing chemicals, began to proliferate due to an accumulation of Bcl-3 in the nucleus, they found. Treatment with a single dose of ultraviolet light--thought...

Combination therapy with a monocloncal antibody and a vaccine leads to tumor rejection

...t blockade of CTLA4 lifts the inhibition of T cell proliferation and allows both Tregs and Teff cells to proliferate in response to exposure to self-antigen. Interestingly, combination of CLTA4 blockade with Gvax selectively primes the anti-tumor Teff cells for action. This led to greater infiltration of Teff cell...

New study reveals signaling pathways required for expansion of pancreas stem cells

...r the roles of two proteins-BMP4 and Id-in causing proliferation or expansion of pancreatic progenitors. Hong Hua, ...ease of Id expression, and if this would result in proliferation of the stem cells." Her work incorporated several techniques to test these hypotheses, including th...

New compound reduces stroke damage

...the rats' neurons and also caused neural stem cell proliferation and neuronal differentiation. Diseased animals with motor behavior deficits also showed improvement when they were given the synthetic drug. These results suggest a potential therapeutic application specific FKBP38 inhibitors in the treatment of neu...

Unique dual target specificity of kinase inhibitor key for success against cancer

...tists have identified a new molecule that inhibits proliferation of a broad range of lethal malignant glioma cells in vitro and in vivo. The findings, published in the May issue of Cancer Cell, shed light on which PI3 kinase family members are most likely to play a role in cancer progression. This study reinforces...

Leptin found to control appetite and limb development in frogs

...th hormone, and it has been found to increase cell proliferation in the brains of rats. Leptin is also found in late-stage fetal humans, mice, and sheep, and appears to be linked to birth weight, but little is known about what role it might be playing overall in fetal growth and development. Denver's study sh...

Nanotechnology being used to improve biocompatibility of human prosthetics and implants

...splats are capable of enhancing the attachment and proliferation of the osteoblast cells. The study also revealed that the dissolution of the Ca/P-rich phases into the culture medium might promote the proliferation/differentiation of the osteoblast cells. ...

No cell walls, no new cancer cells

...tor of SREBP1 might reduce the rate of cancer cell proliferation to slow down tumor growth, or might enhance the effect of targeted therapies that aim to actually kill cancer cells." ...

'LEGO-Like' building blocks to halt cell growth wins Hebrew University prize

...F-1 is a protein that plays a critical role in the proliferation of many cancers, including prostate, lung, breast, colon and brain cancers. The binding action of the molecule to the receptor inhibits the activation of the IGF-1 protein in the cells, thus halting the cancerous growth. Through this process of "co...

Green tea and the 'Asian Paradox'

...atelet aggregation, regulates lipids, and promotes proliferation and migration of smooth muscle cells, which are all factors in reducing cardiovascular disease, he said. Sumpio said other reports show that EGCG prevents growth of certain tumors. Tea, according to studies, also can improve gastrointestinal functi...

Weizmann Institute scientists discover a molecular security mechanism for keeping mutations in check

... might get out of control and lead to an unhealthy proliferation of mutations. Prof. Livneh and his team recently...discovered a security mechanism that prevents such proliferation of mutations. This mechanism allows the right enzyme to go to work at the right time, and only when ...

Why mice don't get cancer of the retina

...tinal progenitor cells and prevent the deregulated proliferation of the cells that leads to retinoblastoma. By contrast, RB1 is the main protein expressed during retinal development in humans. The protein p107 is only slightly expressed during development and cannot compensate for the lack of RB1, which leads to r...

Killing brain tumors from within: A 'Trojan horse' approach

...epidermal growth factor receptors (EGFR). This proliferation of EGFR is typical of certain types of cancer cells, including glioblastoma multiforme (GBM), the most lethal form of brain cancer. The nucleic acid-EFG molecule acts as a "guided missile," explained Prof. Levitzki, which, when injected into the ...

How does a zebrafish grow a new tail?

...another related protein, Wnt8, also increases cell proliferation in the regenerating fin. "We can actually increa...l and is required for the formation and subsequent proliferation of the progenitor cells of the blastema." A blastema is a little nub of cells that directs regenerat...

Plutonium or greenhouse gases? Weighing the energy options

...ar and a greatly increased risk of nuclear weapons proliferation or diversion of nuclear material into terrorists' ...l warming, the issues of nuclear waste and weapons proliferation are footnotes in the discussion," said Ewing, who is the Donald R. Peacor Collegiate Professor and C...

Sunflower speciation highlights roles for transposable elements in evolution

...e same two parental types have undergone a massive proliferation of genetic entities known as transposable elements...al sunflower species are associated with a massive proliferation of transposable genetic elements that has occurred independently in the genome of each hybrid specie...

Cigarette smoking impedes tendon-to-bone healing

...esearchers also noted that there was less cellular proliferation in the rats' surgically repaired shoulders and decreased collagen production, leading to inferior healing. "When you have an injury and a repair, new cells come in and start to facilitate healing," Galatz says. "When the new cells arrive, they mak...

Stem cell activity deciphered in the aging brain

...enriching environment, that are known to stimulate proliferation of stem cells. ...

Two central mysteries in genome inheritance solved at UCSD

...n that breakdown of this connection could stop the proliferation of cancerous cells, they didn't know how the connection itself was established. Using a biochemical approach, Desai and postdoctoral fellow Iain Cheeseman, Ph.D., have solved this mystery. In the December 1 paper, they identified a protein group ...

1 2 3 4 5 6