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Tag: "proliferation" at biology news

Scientists discover that widely available drug also helps fight kidney disease

...emia combined. The disease is characterized by the proliferation of cysts that eventually debilitate the kidney, ca...n of mTOR. This, in turn, causes excess growth and proliferation of kidney cells, which results in the formation of thousands of cysts that eventually destroy the ki...

Viral protein helps infected T cells stick to uninfected cells

...ease characterized by a long latent period and the proliferation of T cells. The infected cells are spread from person to person during sexual activity and by blood and breast milk. In the body, the HTLV-1 mainly targets immune-system cells known as CD4 T lymphocytes. These immune cells coordinate immune respons...

New cellular flaw found in some virulent breast cancers

...tch, CDK4 kinase, causing it to unleash a virulent proliferation of cancer cells and creating a tumor with a very poor prognosis. "The development of cancer drugs like Gleevec and Iressa have shown that it is possible to block the action of kinases," said Sicinski, "so we hope that these findings will stimulate i...

Single microRNA causes cancer in transgenic mouse

...mmature B cells. "This is significant, because a proliferation of these precursor B cells is one of the hallmarks of some types of leukemia and lymphoma," he said. B cells, or lymphocytes, are white blood cells that help the body fight infection. In humans, they are produced from stem cells in the bone marro...

Scientists discover a genetic switch that links animal growth and cancer

...not only analogous to the inappropriate growth and proliferation of cells during the formation of tumors in cancer, it also involves the same players," said Rothman. The research team found that PTEN functions with two other proteins –?known as protein kinases –?that are also involved in cancer progression. This ...

New insight into machinery of immune cells' 'tentacles'

...ce deficient in Abi proteins have decreased T cell proliferation in response to activating stimuli, found the researchers. "These findings add important new players in the regulatory pathway downstream of Rac," said Pendergast. "And since immune system activation depends critically on the formation of the synapse...

Growth factor-promoting angiogenesis expressed in tumor cells and normal neurons

...CF expression is not directly linked to tumor cell proliferation but instead encourages the growth of blood vessels needed to support the expanding tumor. Importantly, these findings provide definitive evidence that factors promoting tumor progression extend beyond the tumor itself and involve a complex interactio...

Protein found to control tumor growth in certain breast cancers

... an increased sensitivity to estrogen-induced cell proliferation and a failure to undergo Nod1-dependent apoptosis in vitro. Taking these initial findings one step further, researchers implanted estrogen pellets in the SCID mice to accelerate tumorigenesis. In those mice receiving Nod1 cell lines tumor growth ...

Hepatitis C therapy: Inhibiting newly discovered microDNA molecule

...of processes as diverse as early development, cell proliferation and cell death, and cell differentiation. Some miRNAs are located throughout the body, while others are found only in specific tissue. The miRNA whose surprising new role was discovered by Dr. Sarnow and his colleagues is located only in the liver. ...

Markers of gene, protein, or micro-RNA activity predict outcome in prostate and colorectal cancers

...s, disorganized tissue architecture, and increased proliferation of crypt cells, which leads to development of colon tumors, Boman said. Hence, they then analyzed malignant colon tissues and found that there are a number of miRNAs that were changed in expression in colon cancer. Boman, who also directs the G.I. C...

AIDS-related cognitive impairment exists in two separate forms

...s, disorganized tissue architecture, and increased proliferation of crypt cells, which leads to development of colon tumors, Boman said. Hence, they then analyzed malignant colon tissues and found that there are a number of miRNAs that were changed in expression in colon cancer. Boman, who also directs the G.I. C...

Inflammation and drugs to control this activity studied in a variety of tumors sites

...ntraepithelial neoplasia and atypical small acinar proliferation that may have been cancerous). In contrast, the researchers found only two cases ?six percent ?in the 33 patients without inflammation who went on to develop cancer, both of whom had other risk factors for cancer. "We observed a significant associa...

Cancer virus protein needed for successful infection

...ease characterized by a long latent period and the proliferation of T lymphocytes. The virus is spread by sexual activity, infected blood and breast milk. For this study, Lairmore and a group of collaborators developed a mutant strain of HTLV-1 that lacked p13. The researchers then infected one batch of rabbit T...

The loss of a protein favors lung tumor growth

... some of the cells she demonstrated that the tumor proliferation was reduced. In particular, in malignant tumors of large cells she observed that their capacity for growth was reduced, independently of their anchoring or invasive capacity, two key characteristics for production of metastasis. Early detection L...

New protein target may advance design of HIV and cancer drugs

...paper, the HIV NCp7 protein is responsible for the proliferation of the HIV virus. If researchers can inhibit the action of this zinc finger protein, they can stop the spread of the virus. "When we target specific viruses with drugs, over time patients can become resistant to treatment and the drug becomes ineff...

Speeding discovery of the 'human cancer genome'

...bute to the cancerous cells' ability for unchecked proliferation or spread. Simply sorting through those differences one by one takes time and money, said Lynda Chin of the Dana-Farber Cancer Institute and Harvard Medical School. "There has to be a way to prioritize the effort," she said. Chin's and Lowe...

Cycles of cell death, proliferation key to liver cancer

...to cell death; if activated briefly, it stimulates proliferation of pre-malignant and cancerous tumor cells," said ...se to liver injury, as well as what stimulates the proliferation of surviving hepatocytes," said Karin. "Since we previously knew that JNK activity is required for n...

Mass. General study finds potential ovarian cancer stem cells

...s potential to maintain the ability to inhibit the proliferation of these cells, MIS may play a role in these new therapeutic approaches," Donahoe says. "We intend to keep searching for stem-like cells in patient tumor samples and to study their responsiveness to both chemotherapeutic agents and to novel agents s...

Mouse mimics chronic leukemia, will aid drug development

...lly strikes people aged 50 or older and causes the proliferation of white blood cells called lymphocytes. Other effects include severe anemia and a high risk of viral, bacterial and fungal infections. Average survival after diagnosis is eight to 12 years. The standard treatment for CLL is the drug fludarabine, but...

'Signature' of chromosome instability predicts cancer outcomes

...ne of the key mechanisms that keeps malignant cell proliferation going," says Zoltan Szallasi, MD, a CHIP researcher and the study's senior investigator. "We have achieved a relatively easy way to measure the level of chromosomal instability in a given tumor sample." The technique may help in the search for canc...

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