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Tag: "proliferation" at biology news

Viral DNA sequence a possible trigger for breast cancer

... immune cells and helps trigger the activation and proliferation of the cells. These sequences have also been found in proteins from some other cancer-causing viruses such as Epstein Barr virus and Kaposi's sarcoma virus, but what role this sequence plays in cancer development has remained unexplored. Katz and co...

Needling Chromosomes Reveals Cell Division Secret

...ormal cell division,called mitosis, as well as the proliferation of sperm and egg cellscalled meiosis."Chromosomes in mitosis and meiosis have to be held together, becauseotherwise they don’t attach to the apparatus called the spindle thatdistributes them to opposite poles," explained Nicklas, who is aResearch Pro...

Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer

...helium) and causes them to lose control over their proliferation leading to tumors. Now Klaus Kaestner from the Un...the epithelium layer and results in increased cell proliferation and turnover of this layer. In people with a genetic predisposition, like those with Familial Adenom...

Rush Physicians Using Gene Therapy For Heart Patients With Moderate To Severe Chest Pains Who Do Not Benefit From Other Treatments

...s the growth of new blood vessels by promoting the proliferation of endothelial cells in the heart. New blood vessels are required to provide oxygen-carrying blood to heart muscles to compensate for the blocked heart arteries. The subsequent, improved blood flow relieves the painful symptoms of angina. "The proc...

Hirsute Or Hairless? Two Proteins May Spell The Difference

... of transgenic mice caused abnormal levels of cell proliferation in the epidermis and reduced cell adhesion. Worki... in turn down-regulates E-cadherin and activates a proliferation pathway in the developing bud. Reduced E-cadherin, the authors conclude, appears to contribute to Sn...

Viral protein influences key cell-signaling pathway

...ease characterized by a long latent period and the proliferation of T lymphocytes. The virus is spread by sexual ac...so lifelong. A hallmark of HTLV-1 infection is the proliferation of T lymphocytes. This sets HTLV-1 apart from HIV, Lairmore says. "Unlike HIV, which kills cells an...

New insight into regulation of blood stem cells

... blood cells, or platelets. The genes that control proliferation and differentiation have been difficult to study u...n to develop compounds that can regulate stem cell proliferation and differentiation. The ability to influence stem cell fate decisions would be expected to have a m...

Researchers uncover sequence of major rice pathogen

... M. grisea genome has been subject to invasion and proliferation of active transposable elements, reflecting the clonal nature of this fungus imposed by widespread rice cultivation. ...

New tumor-suppressor gene discovered

...e cell number and tissue growth by restricting the proliferation of cells and promoting their timely death," Lai sa...hen they combine to work together in reducing cell proliferation and promoting cell death, so the tissues get much smaller." Lai's lab also performed other experimen...

Compounds in plastic packaging act as environmental estrogens altering breast genes

...00 days." These included proteins regulating cell proliferation and differentiation, including tumor-suppressing proteins and a large number of unknown proteins. The exception was decreased expression of the GAD1 gene. It encodes a key enzyme of the GABA-ergic system, which could be involved in hormonal regulatio...

How A Latent Virus Eludes Immune Defenses

..., can induce uncontrolled lymphocyte (immune cell) proliferation and result in lymphoma, Hodgkin’s disease, and Kaposi’s sarcoma. These diseases arise from the persistent latent infections that take hold after initial infections are controlled by immune defenses. The episome maintenance protein produced by EBV, ca...

Touching Molecules With Your Bare Hands

..., can induce uncontrolled lymphocyte (immune cell) proliferation and result in lymphoma, Hodgkin’s disease, and Kaposi’s sarcoma. These diseases arise from the persistent latent infections that take hold after initial infections are controlled by immune defenses. The episome maintenance protein produced by EBV, ca...

Gov't Creates Gene Database of Normal Human Tissues

... of cancer -- processes such as apoptosis, growth, proliferation and transcription," said Khan. These results provide scientists studying and treating NB with a focused set of genes to explore. ...

U of T researchers map role of Epstein-Barr virus in cancer

...sing because all other viruses that stimulate cell proliferation do it through p53. The question was why this one didn't. What our research shows is that EBNA1 does actually impact on the p53 protein; it just does it in a different way than other viruses do." Frappier, a Canada Research Chair in Molecular Virolog...

Discovery of New Dopamine Action May Yield Alternative Psychiatric Drugs

...y, including inflammation, cell death and the cell proliferation that can spur cancer, the researchers added. Therefore, similar mechanisms might also underlie other disease pathways. Collaborators on the study include Tatyana Sotnikova, Sebastien Marion, Robert Lefkowitz and Raul Gainetdinov, all of Duke. The wo...

Study: Harmless virus kills some cancers

...w cell-cycle progression by decreasing cancer cell proliferation rates and causing growth arrest. In this study, the team first used HPV infected epithelial cells and normal human epithelial cells, which are natural hosts for both AAV2 and HPV. In cultures infected with both AAV2 and HPV, the team found that afte...

Unexpected lock and key mechanism found for the assembly of tumor blood vessels

...bled could help lead to effective ways to stop the proliferation of cancer cells by cutting off their nutrient supply, Varner added. Drs. Varner and Parker are currently in discussions with pharmaceutical companies to test integrin inhibitors in cancer clinical trials at the new Moores UCSD Cancer Center. Varner'...

Stem Cells Found In Cerebellum; Possible Cell of Origin for Childhood Brain Tumors

...become activated at the wrong time or place, rapid proliferation can give rise to cancer, said Wechsler-Reya. The researchers discovered the stem cells while studying the development of granule cells, the most abundant type of neuron in the cerebellum. While purifying granule cell precursors, they discovered what...

HIV Therapy Greatly Extends Life of Key T Cells, Scientists Find

...mbers of new CD4+ cells. “More remarkable than the proliferation of these cells was how long they lived,?says Dr. Kovacs. The average lifespan of CD4+ cells in healthy individuals as measured with this technique is about four weeks, according to Dr. Kovacs. In contrast, the average lifespan of CD4+ cells in 15 HIV...

MicroRNA tweaks protein that controls early heart development

...the early stages of embryonic development to allow proliferation and expansion of a pool of muscle progenitor cells that can eventually develop into the heart," said Dr. Deepak Srivastava, senior author of the paper. "But at some point production of Hand2 needs to be shut off so the cells can go on to the next sta...

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