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Tag: "progression" at biology news

Test reveals effectiveness of potential Huntington's disease drugs

...Memantine has also shown evidence of retarding the progression of Huntington's in people, while riluzole has helped relieve some symptoms. "Our results provide the first systematic comparison of various clinically relevant glutamate pathway inhibitors for HD treatment and indicate that memantine holds the mo...

Rhesus monkeys in Nepal may provide new alternative for HIV/AIDS research

...ehavioral and physiological differences in disease progression between animals from the two countries, and the In...nown to influence immunity and the rate of disease progression in the animals, including one that is present in Indian rhesus macaques but not in the Chinese ones....

AIDS study challenges conventional treatment guidelines for HIV patients

...icted by his or her viral load. Predicting disease progression is crucial in the treatment of HIV-positive people, such as in making the decision as to when it is best for starting antiretroviral therapy. Current treatment guidelines, while diminishing its importance, continue to include HIV viral load as one e...

How many genes does it take to learn? Lessons from sea slugs

... The findings suggest that acts of learning or the progression of brain disorders do not take place in isolation - large clusters of genes within an untold amount of cells contribute to major neural events. "For the first time we provide a genomic dissection of the memory-forming network," said Leonid Moroz,...

Tuberculosis: The bacillus takes refuge in adipose cells

... team, with each infectious agent facilitating the progression of the other. Neyrolles' team first demonstrated, in cell and tissue cultures, that adipose cells served as a reservoir for Mycobacterium tuberculosis, and that this protected the bacillus against isoniazid. They then investigated whether the patho...

Plague proteome reveals proteins linked to infection

...eome Research. Biomarkers associated with disease progression show promise as detection tools in public health and biodefense and can guide drug and vaccine designers in their quest to disrupt the microbe’s ability to infect. Y. pestis is the bacterium that caused the infamous Black Death plagues. Fleas are...

Gene therapy for hereditary lung disease advances

.... It does not cure, but it does appear to slow the progression of this disease. Patients in the clinical trial - 10 men and two women who ranged from 42 to 69 - were asked to discontinue their replacement therapy 28 days before receiving the gene therapy. One volunteer who had not been on protein replacem...

Effective HIV control may depend on viral protein targeted by immune cells

...ic infection for more than a decade, compared with progression to AIDS within two to three years of infection in those with no Gag responses. The reason why patients?particular HLA Class I molecules are linked to different HIV disease outcomes now appears to be related to the number of Gag fragments displayed b...

Two-faced protein can stop metastasis or promote it, researchers say

... But when E-cadherin production is lost during the progression of cancer, p120 catenins begin binding to mesenchymal cadherins. And when that happens, the researchers found that p120 unexpectedly switches on a cascade of events that promote cell movement. "We show that E-cadherin suppresses invasion, at least i...

Experimental cancer drugs counter muscle deterioration seen in muscular dystrophy

...pair of dystrophic muscles, thereby countering the progression of the disease, in two different mouse models of muscular dystrophy. Led by Burnham Institute assistant professor Lorenzo Puri, M.D., Ph.D., in collaboration with the Dulbecco Telethon Institute (DTI) of Rome and other colleagues in Italy and at the ...

Newly discovered behavior in cancer cells signals dangerous metastasis

...ng the various steps that occur during the natural progression of tumors could lead to therapies for blocking metastasis, he said. ...

High HPV concentrations combined with smoking significantly raise risks of cervical cancer

...uppression. Conversely, it could be related to the progression of neoplastic growth, since HPV and smoking appear to alter the levels of certain cytokines, which are involved in controlling abnormal cell growth. More likely, the combination of both mechanisms are contributory factors. In any event, confirmati...

New engineered drug may offer prolonged arthritis relief

... the modified drug's ability to interfere with the progression of disease in the joints of animals. ...

Novel regulatory mechanism identified for key tumor suppressor p53

...ing approaches to diagnosing or intervening in the progression of many types of cancer. A report on the team's findings will be published online November 15 in the journal Nature. "The p53 protein is vital for controlling cancer throughout the body," says Shelley L. Berger, Ph.D., the Hilary Koprowski Professo...

Road-crossing in chimpanzees: A risky business

... when retreating, but comparable data on great-ape progression orders have been lacking. Crossing of man-made roads, sometimes necessitated by intersection with longstanding chimpanzee travel routes, presents a new situation that calls for flexibility of responses by chimpanzees to variations in perceived risk. ...

Antibiotic treats lymphoma of the eye

...e or negative for chlamydia. They looked for tumor progression every 6 months. The authors found that doxycycline treatment caused lymphoma to regress in both patients who did not test positive for the disease and those who did. They suggest that doxycycline may be a useful therapy even in patients where other...

Math model predicts cancer behavior

...ke this will be used to predict a tumor's clinical progression and formulate individualized treatment plans. For the last two years, he has headed a major effort to develop the kind of mathematical model for cancer invasion powerful enough for this purpose. The result was published as an entirely theoretical pap...

Early-stage immune system control of HIV may depend on inherited factors

... I previously associated with slower HIV-1 disease progression also contribute more to this initial antiviral immune response," says Marcus Altfeld, MD, PhD, of PARC/MGH, the paper's lead author. An essential aspect of the immune response involves educating T cells to recognize pathogens or other "non-self" ...

New study aims to stop sepsis in its tracks

...ermine whether specific interventions can halt the progression to severe sepsis and septic shock. Key to the project is determining whether there are "golden hours" during which prompt, rigorous, standardized care can save patients' lives. The project may establish the first set of standard procedures to diagn...

Stress hormones may play new role in speeding up cancer growth

...t would block these receptors and perhaps slow the progression of the disease," Glaser said. "Using this approach may not cure this cancer but perhaps we could slow down its growth, making the tumor more sensitive to anti-cancer therapy, and therefore extending the patient's lifespan and improve their quality...

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