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Tag: "progression" at biology news

The molecular mechanism of a diabetes vaccine revealed

...nd colleagues developed a vaccine that arrests the progression of Type 1 diabetes in laboratory animals. They had discovered that a particular protein called HSP60, or even only a small particular fragment of it ?the peptide designated p277 ?is able to shut down the autoimmune response causing this disorder. The...

How HIV 'exhausts' killer T cells

...urement might tell us more about the likelihood of progression of the disease and need for treatment in infected people," he said. Walker said that scientists know little about the evolutionary purpose of a pathway that would deactivate such an important component of the immune system in the face of a vira...

A new tool against brain disease

...urement might tell us more about the likelihood of progression of the disease and need for treatment in infected people," he said. Walker said that scientists know little about the evolutionary purpose of a pathway that would deactivate such an important component of the immune system in the face of a vira...

Study identifies new role for breast cancer susceptibility gene

... also often correlated with accelerated growth and progression of breast tumors and with increased tumor blood vessel formation. In order to better understand the link between BRCA1 and tumor progression, Dr. Wen-Hwa Lee and colleagues from the Department of Biological Chemistry at the University of California, ...

HIV-1's high virulence might be an accident of evolution

...o the heightened immune activation associated with progression to full-blown AIDS, reports Frank Kirchhoff of the...2 strains might explain differences in the rate of progression to disease in infected humans. ...

New study reveals signaling pathways required for expansion of pancreas stem cells

...ick's lab, was the lead author of this study. The progression of pancreatic stem cells to beta cells is governed by the expression of key proteins, including a class of proteins called bHLH transcription factors that regulate gene expression. Ids (inhibition of differentiation factors) are a family of proteins ...

Unique dual target specificity of kinase inhibitor key for success against cancer

...ch PI3 kinase isoforms are critical for growth and progression of malignant glioma cells. UCSF colleagues Zachary Knight and Kevan Shokat synthesized and characterized a series of novel inhibitors that span the different PI3 kinase isoforms (described in the May issue of Cell). Qi-Wen Fan in the Weiss lab screen...

Gene therapy injected into the brains' of mice with Huntington's disease

...study suggests a new approach to forestall disease progression in newly diagnosed HD patients by delivering potent trophic factors with effects that are long-term and non-toxic." "If these results can be replicated in HD patients, it would represent a significant advance in the treatment of this tragic disease...

Meth promotes spread of virus in HIV-infected users

...receptors interact with each other, leading to the progression of HIV disease in meth-using HIV-infected subjects. That is the next question we want to answer. "Since meth mediates its effects through interacting with dopamine receptors present on the cells, and meth increases DC-SIGN, which are the HIV at...

Higher risk for cervical cancer seen among women infected with multiple HPV types

...e the pre-cancerous mutations or to expedite their progression to cancer. They also suggest that the presence of HPV co-infections may indicate that a woman's immune system is not particularly effective in clearing viruses. This new research is the first prospective study using multiple measurements longitudin...

Researcher studies, treats military with 'silent disease'

...y was taken. "It's the only way to establish the progression of the disease," Sjogren said. Her patients, ranging in age from 18 to the upper 50s, mostly come from the Northeast because of its proximity to Walter Reed. Thirty percent of the study volunteers had minimal liver disease, Sjogren said. Of the 70 p...

Links between DNA damage and breast cancer studied

...n the early stages of breast cancer initiation and progression is not well understood. In two recent papers*, the PNRI/NIST team explored the occurrence of damage to stromal DNA caused by free radicals and other oxidants. NIST researchers used a high-precision chemical analysis technique (liquid chromatography...

Activation of microRNA inhibits cancer gene in human cancer cells

...et genes that are important in the development and progression of human cancer. Further studies on epigenetic regulation of miRNA expression are necessary, and regulation of miRNA expression by epigenetic treatment may be a novel strategy for prevention or treatment of human cancer," offers Dr. Jones. ...

Triple threat polymer captures and releases

...gned to be anti-fouling materials -- they found a progression of decreasing temperature as they went with different amounts of poly(ethylene glycol) relative to hyperbranched fluoropolymer in the composite material. "What's amazing is that there is a 55 degree temperature reduction at which this small molecul...

Healing the heart with bone marrow cells

...bone marrow cells after a heart attack may prevent progression of heart failure in patients who survived a heart attack. The study may explain why some patients have mild heart attacks and others develop progressive and potentially fatal congestive heart failure. "We know that the number of c-kit positive cells...

A surprise about our body clock

...bone marrow cells after a heart attack may prevent progression of heart failure in patients who survived a heart attack. The study may explain why some patients have mild heart attacks and others develop progressive and potentially fatal congestive heart failure. "We know that the number of c-kit positive cells...

RNA found in the cellular centrosome of surf clams

...trosome may help researchers better understand the progression of diseases such as cancer, which has been linked to abnormal centrosome numbers in tumor cells," says Palazzo. The study on surf clam centrosomes was initiated at the MBL, an international biological research center where scientists use locally ab...

Expanding waistlines triggered by your genes

...bly will provide novel therapeutics to prevent the progression of obesity. The researchers will continue to work on the cellular mechanism of obesity and metabolic diseases from the perspective of 3-D cell biology. ...

Analysis of breast-cancer gene role offers promising target

...g target for therapeutic drugs to stop or slow the progression of the disease and could serve as a screening tool for assessing which types of drugs a patient will respond to. The gene launches a biochemical process in which a molecule called plasmin perforates the membranes of tissues, causing the membranes...

Epstein-Barr virus might kick-start multiple sclerosis

...immune response contributes to the development and progression of the disease." Lünemann started the research as a postdoctoral fellow at NIH. He is continuing to investigate the role of Epstein-Barr virus in MS in the lab of Christian Münz, a Rockefeller University researcher who specializes in EBV-specific i...

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