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Tag: "progression" at biology news

New compound stops brain cell degeneration in Alzheimer's disease

...188WH and related compounds slowed or reversed the progression of the neuroinflammatory cascade and reduced human amyloid beta-induced glia activation in a mouse specially designed to develop many of the signs of Alzheimer's disease, including neuroinflammation, neuronal and synaptic degeneration and behavioral ...

Anthrax inhibitor counteracts toxin, may lead to new therapeutics

...sease Control and Prevention. Antibiotics slow the progression of infection by targeting the bacteria, but do not counter the advanced destructive effects of anthrax toxin in the body. Anthrax toxin is a polyvalent protein complex in that it displays multiple copies of identical binding surfaces on the same str...

International HIV/AIDS trial finds continuous antiretroviral therapy superior to episodic therapy

...ing episodic therapy had twice the risk of disease progression (the development of clinical AIDS or death), the m...reatment faced more than twice the risk of disease progression relative to participants on continuous ART. Furthermore, there was an increase in major complication...

Access to antiretrovirals unlikely to reduce HIV infection rates

.... Because antiretrovirals therapy (ART) slows AIDS progression and reduces viral load in infected individuals, the drugs not only improve the health and prolong the life of those who take them, but also make it less likely that they infect others. As a consequence, ART has been discussed not only as a treatment ...

Intensive statin therapy may partially reverse plaque build-up in arteries

...ed that intensive statin therapy could prevent the progression of coronary atherosclerosis, or arterial plaque bu...atheroma, burden during treatment. Atherosclerosis progression was assessed at baseline and after at 24 months of treatment. "Previous similar studies with stati...

'Genetic network' guards against lethal DNA damage

...ication, the halting of replication and cell cycle progression by "checkpoints" so that damaged DNA can undergo repair, and responses to oxidative stress necessary for reducing the intracellular levels of highly reactive molecules that bind to and damage DNA. The yeast has about 6,000 genes, of which about 1,00...

Measuring artery repair cells could become new heart disease test

...nary vessels. Recent Duke research has linked the progression of the artery-clogging disease atherosclerosis to the inability of EPCs to continuously repair damage to the arterial lining. Duke researchers have shown that -- while risk factors such as poor diet, smoking, high cholesterol levels and inactivity ar...

Computer simulation hints at new HIV drug target

..., in some cases, been effective in controlling the progression of disease and prolonging survival. It has succeeded where other therapies have failed because HAART therapy makes it difficult for even a fast-mutating virus like HIV to develop resistance to all of the drugs at once. But the specter of drug resist...

Major WHO study concludes calcium supplements can reduce complications during pregnancy

..., in some cases, been effective in controlling the progression of disease and prolonging survival. It has succeeded where other therapies have failed because HAART therapy makes it difficult for even a fast-mutating virus like HIV to develop resistance to all of the drugs at once. But the specter of drug resist...

New study shows benefit of early therapy in HIV-infected infants

...round balancing the benefits of preventing disease progression and the risks and costs of life-long therapy begun within months of birth. Policies on when to start ART vary across Europe. Up to this point, the effect of age on clinical outcome has been difficult to assess because CD4 cell counts--an immunologic...

Cyclosporine inhibits hepatitis C virus in vitro

...rvations. "Due to the accelerated rate of disease progression and graft failure after liver transplantation in HCV patients," the authors conclude, "it will be very important to determine the ideal immunosuppression regimen." ...

Genome changes tracked during multiple myeloma initiation, progression and treatment

...genetic events associated with the development and progression of multiple myeloma (MM), an incurable malignancy that is the second most common cancer of the blood. The results, published in the April issue of Cancer Cell, provide new genetic and biological insights that open innovative directions for the discov...

Growth factor-promoting angiogenesis expressed in tumor cells and normal neurons

...e definitive evidence that factors promoting tumor progression extend beyond the tumor itself and involve a complex interaction between the cancer cells and the normal cells that are perturbed by expanding tumor. These results suggest that SCF is a potent glioma-associated angiogenic factor that plays a promine...

Scientists discover new genetic subtypes of common blood cancer

...dentify many new genes implicated in the cause and progression of myeloma, and the product of those genes can be ...y these myriad abnormalities in the initiation and progression of myeloma are only beginning to be understood, but it's been observed that different abnormalities...

Loosen leash on cancer protein 'watchdog,' researchers say

...und naturally in cells has the ability to halt the progression of intestinal tumors that arise from genetic predisposition. When the activity of this protein, known only by the technical name of p53, was artificially increased in the cells of laboratory mice, those known to have a hereditary predisposition for d...

How nice, brown rice: Study shows rice bran lowers blood pressure in rats

...ress plays an important role in the initiation and progression of cardiovascular diseases,?explained lead author Ardiansyah [ editor note: name is correct as written, there is no first name ], a Ph.D. candidate at the university’s School of Agricultural Science. He added one more element to the research that is...

Tramiprosate (Alzhemed? preclinical results published in Neurobiology of Aging

...ct of this product candidate to slow or arrest the progression of AD. While the paper issue of the publication will be available in a future issue of Neurobiology of Aging, an electronic version of the article entitled "Targeting soluble Aβ peptide with Tramiprosate for the treatment of brain amyloidosis" is ...

New MRI technique shows emphysema in asymptomatic smokers

...sible to measure the severity of emphysema and its progression through time without the radiation exposure of lung CT tests," said Sean B. Fain, Ph.D., lead author and assistant professor of medical physics and radiology at the University of Wisconsin, Madison. Emphysema is a chronic, progressive lung disease, ...

Malignant melanoma cells secrete protein required for embryo formation

... cellular communication is integral to both cancer progression and embryological development. The significance of the research team's finding is profound in that it implies that through secretion of Nodal, aggressive melanoma cells maintain their plasticity and modulate the microenvironment, as exemplified by...

Memory loss affects more of the brain than previously thought

... together can best predict early onset and monitor progression of AD. "If memory problems are beginning to impact the day-to-day life of you and your family, you should undergo comprehensive testing by a physician, as memory loss can be caused by many underlying factors such as depression, thyroid problems and...

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